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A Model of Weak Interaction

Weak interactions are interpreted from the standpoint of composite model like the Nagoya model with two neutrinos (νe and νµ). A new boson called ε′-change is introduced. It has nearly the same properties as the ε-charge (negative charged vector boson), and has no strong interaction with leptons. Assuming a suitable interaction Lagrangian between ε, ε′, νe and νµ, and that...

A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile

Background The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months. This poor prognosis is attributable to difficulty of early detection. Here we developed and evaluated a multivariate index composed of plasma free amino acids (PFAAs) for early detection of PC. Methods We conducted a...

A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice

Many factors are involved in the pathogenesis of diabetic nephropathy. A single gene abnormality may be prerequisite but insufficient to the disease to manifest. It is therefore only when a second or sometimes a third damage is associated that the consequences of pathogenic phenotypes become evident. We generated the triple transgenic mice overexpressing megsin (a novel...

A Vacuum with Double Structure

For the purpose of proving the conservation of norm in the field theory of complex mass proposed by one of the present authors, a new space is introduced where the state vectors have a double structure and the norms are complex numbers in general. The new space contains the Hilbert space as a subspace where the norms are real and positive. It is shown that the S-matrix transforms...

Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging

, Hiroshi Yamamoto. 9 / 11 Data curation: Akitoshi Inoue, Shinichi Ohta, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Toru Obata. Formal analysis: Akitoshi Inoue, Akira Furukawa, Shinichi Ohta, Nguyen ... Dai Hung Linh, Tulyeubai Syerikjan. Methodology: Akitoshi Inoue, Akira Furukawa, Hiroshi Yamamoto, Shinichi Ohta. Project administration: Akira Furukawa, Hiroshi Yamamoto. Supervision: Akira Furukawa

Alteration in plasma free amino acid levels and its association with gout

Hiroki Amano Mikiko Kobayashi-Miura Hideyuki Kanda Yasuyuki Fujita Hiroshi Yamamoto Mai Yamamoto Shinya Kikuchi Atsuko Ikeda Naoko Kageyama Mina Nakamura Yasutaka Ishimaru 0 Hiroshi Sunagawa 0 Tsuyoshi

Alteration in plasma free amino acid levels and its association with gout

Studies on the association of plasma-free amino acids with gout are very limited and produced conflicting results. Therefore, we sought to explore and characterize the plasma-free amino acid (PFAA) profile in patients with gout and evaluate its association with the latter. Data from a total of 819 subjects (including 34 patients with gout) undergoing an annual health examination...

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

publication 15 December 1983 1 YUTAKA YONEMURA , TORU TAKASHIMA, KOICHI MIWA, ITSUO MIYAZAKI, HIROSHI YAMAMOTO, AND HIROSHI OKAMOTO SUMMARY Ninety percent depancreatized rats received daily intraperitoneal

An Arabidopsis cDNA encoding a DNA-binding protein that is highly similar to the DEAH family of RNA/DNA helicase genes

A cDNA encoding a putative RNA and/or DNA helicase has been isolated from Arabidopsis thaliana cDNA libraries. The cloned cDNA is 5166 bases long, and its largest open reading frame encodes 1538 amino acids. The central region of the predicted protein is homologous to a group of nucleic acid helicases from the DEAD/H family. However, the N- and C-terminal regions of the...

Antisense display—a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes

Presented here is an antisense-oriented method for functional gene screening, which we propose naming ‘antisense display’. In principle, it consists of four steps: (i) preparation of phosphorothioate antisense repertoires that would correspond to the Kozak's consensus sequence, (ii) subgroup screening to identify active antisense molecules that could cause changes in the cellular...

Approximate Solution of the Relativistic Two-Body Equation and its Application to the Nuclear Forces

The approximate but analytical solutions of Bethe-Salpeter equation are given and the relations between binding energy and coupling constant are obtained. With the use these solutions the validity of the non-relativistic approximation (i.e. neglect of retardation and recoil) is investigated.

Association between Reduction of Plasma Adiponectin Levels and Risk of Bacterial Infection after Gastric Cancer Surgery

Background and Purpose Infections are important causes of postoperative morbidity after gastric surgery; currently, no factors have been identified that can predict postoperative infection. Adiponectin (ADN) mediates energy metabolism and functions as an immunomodulator. Perioperative ADN levels and perioperative immune functioning could be mutually related. Here we evaluated a...

Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes

journals • PubMed • Google Scholar Search for Taiki Yamaji in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google Scholar Search

Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome

Scholar Search for Hideyuki Kanda in:Nature Research journals • PubMed • Google Scholar Search for Yasuyuki Fujita in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

Jinhua Li Xinli Qu Jun Yao Georgina Caruana Sharon D. Ricardo Yasuhiko Yamamoto Hiroshi Yamamoto John F. Bertram OBJECTIVE-A multicenter, controlled trial showed that early blockade of the renin

Bound States in Four-Nucleon Coupling

An interaction Lagrangian of general four-nucleon coupling is assumed and equations for nucleon-antinucleon and two-nucleon systems in three types of chain approximation are derived from the interaction and solved exactly. Then the mathematical structure of the solutions is studied in various cases, and the regions where the value of the coupling constant must lie in order to...

Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity

Hashisako,1,4 Yukio Kashima,5,6 Tomoshi Tsuchiya,7 Naoya Yamasaki,7 Takeshi Nagayasu,7 Hiroshi Yamamoto,2 Junya Fukuoka1,6 1Nagasaki Educational and Diagnostic Center of Pathology (NEDCP), Department of

Budd-Chiari Syndrome with Multiple Thrombi due to a Familial Arg42Ser Mutation in the Protein C Gene

A 34-year-old Japanese woman was admitted to our hospital complaining of developing bilateral pedal edema. Imaging studies led to a diagnosis of Budd-Chiari syndrome combined with internal jugular vein thrombus. We investigated the cause of thrombosis and found that the anticoagulant activity of protein C was decreased. Genetic analysis showed the presence of a c.125C>A (Arg42Ser...

Budd-Chiari Syndrome with Multiple Thrombi due to a Familial Arg42Ser Mutation in the Protein C Gene

A 34-year-old Japanese woman was admitted to our hospital complaining of developing bilateral pedal edema. Imaging studies led to a diagnosis of Budd-Chiari syndrome combined with internal jugular vein thrombus. We investigated the cause of thrombosis and found that the anticoagulant activity of protein C was decreased. Genetic analysis showed the presence of a c.125C>A (Arg42Ser...

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Hironori Kitade Kazuki Sawamoto Mayumi Nagashimada Hiroshi Inoue Yasuhiko Yamamoto Yoshimichi Sai Toshinari Takamura Hiroshi Yamamoto Ken-ichi Miyamoto Henry N. Ginsberg Naofumi Mukaida Shuichi