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28 papers found.
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Climatotherapy in Japan: a pilot study

Twenty-nine urban inhabitants participated in a half-day climatotherapy programme at the moderate mountain area and lowland area in the northwest part of the main island of Japan. The current study was aimed to investigate physically and mentally the objective and subjective influence of our short programme, which was a prospective pilot study of single intervention. Blood...

A case of duodenal malignant lymphoma presenting as acute pancreatitis: systemic lupus erythematosus and immunosuppressive therapy as risk factors

We thank Dr. Ayako Nakajima from the ImmunoRheumatology Center, Mie University, for her kind support. Compliance with ethical standards Conflict of interest Reiko Yamada, Takashi Sakuno, Hiroyuki Inoue

A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors

, Hiroyuki Inoue, Kenzaburo Tani. Formal analysis: Junji Kishimoto. Funding acquisition: Yasuki Hijikata, Yoichi Nakanishi. Investigation: Yoshihiro Tanaka, Mutsunori Murahashi, Yuichi Yamada, Kazunari ... Yamada, Atsushi Takahashi, Hiroyuki Inoue, Yoshinao Oda. Methodology: Toshihiko Okazaki, Yoshihiro Tanaka, Yuichi Yamada, Junji Kishimoto, Yoshinao Oda, Yusuke Nakamura. Resources: Atsushi Takahashi

Long-term change and variation of salinity in the western North Pacific subtropical gyre revealed by 50-year long observations along 137°E

The 137°E repeat hydrographic section for 50 winters during 1967–2016 has been analyzed to examine interannual to interdecadal variations and long-term changes of salinity and temperature in the surface and intermediate layers of the western North Pacific, with a particular focus on freshening in the subtropical gyre. Rapid freshening on both isobars and isopycnals began in the...

Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein

A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of a...

Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein

A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of a...

Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid

Nephrology, Keio University School of Medicine, Tokyo, JapanChikako Fujii, Kazutoshi Miyashita, Masanori Mitsuishi, Masaaki Sato, Kentaro Fujii, Hiroyuki Inoue, Aika Hagiwara, Sho Endo, Asuka Uto, Masaki ... for Masaaki Sato in:Nature Research journals • PubMed • Google Scholar Search for Kentaro Fujii in:Nature Research journals • PubMed • Google Scholar Search for Hiroyuki Inoue in:Nature Research

Contribution of a family 1 carbohydrate-binding module in thermostable glycoside hydrolase 10 xylanase from Talaromyces cellulolyticus toward synergistic enzymatic hydrolysis of lignocellulose

Background Enzymatic removal of hemicellulose components such as xylan is an important factor for maintaining high glucose conversion from lignocelluloses subjected to low-severity pretreatment. Supplementation of xylanase in the cellulase mixture enhances glucose release from pretreated lignocellulose. Filamentous fungi produce multiple xylanases in their cellulase system, and...

Enhancing cellulase and hemicellulase production by genetic modification of the carbon catabolite repressor gene, creA, in Acremonium cellulolyticus

Acremonium cellulolyticus is one of several fungi that offer promise as an alternative to Trichoderma reesei for use in industrial cellulase production. However, the mechanism of cellulase production has not been studied at the molecular level because adequate genetic engineering tools for use in A. cellulolyticus are lacking. In the present study, we developed a gene disruption...

Xylanase (GH11) from Acremonium cellulolyticus: homologous expression and characterization

Cellulosic materials constitute most of the biomass on earth, and can be converted into biofuel or bio-based materials if fermentable sugars can be released using cellulose-related enzymes. Acremonium cellulolyticus is a mesophilic fungus which produces a high amount of cellulose-related enzymes. In the genome sequence data of A. cellulolyticus, ORFs showing homology to GH10 and...

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

Background EGFRvIII is a mutant form of the epidermal growth factor receptor gene (EGFR) that lacks exons 2–7. The resulting protein does not bind to ligands and is constitutively activated. The expression of EGFRvIII is likely confined to various types of cancer, particularly glioblastomas. Although an anti-EGFRvIII vaccine is of great interest, low-molecular-weight substances...

Differentiation of ring-substituted bromoamphetamine analogs by gas chromatography–tandem mass spectrometry

-ku, Chiba 260-0045 , Japan 1 National Research Institute of Police Science , 6-3-1 Kashiwanoha, Kashiwa 277-0882 , Japan 2 & Hiroyuki Inoue 3 Biochemical Toxicology Laboratory, Faculty of

Identification and characterization of core cellulolytic enzymes from Talaromyces cellulolyticus (formerly Acremonium cellulolyticus) critical for hydrolysis of lignocellulosic biomass

Background Enzymatic hydrolysis of pretreated lignocellulosic biomass is an essential process for the production of fermentable sugars for industrial use. A better understanding of fungal cellulase systems will provide clues for maximizing the hydrolysis of target biomass. Talaromyces cellulolyticus is a promising fungus for cellulase production and efficient biomass hydrolysis...

Crystal Structure of Talaromyces cellulolyticus (Formerly Known as Acremonium cellulolyticus) GH Family 11 Xylanase

Misumi Kataoka Fusamichi Akita Yuka Maeno Benchaporn Inoue Hiroyuki Inoue Kazuhiko Ishikawa Talaromyces cellulolyticus (formerly known as Acremonium cellulolyticus) is one of the mesophilic fungi

Proliferation of neutral modes in fractional quantum Hall states

of Condensed Matter Physics, Weizmann Institute of Science, Rehovot 76100, IsraelHiroyuki Inoue, Anna Grivnin, Yuval Ronen, Moty Heiblum, Vladimir Umansky & Diana Mahalu AuthorsSearch for Hiroyuki ... Inoue in:Nature Research journals • PubMed • Google ScholarSearch for Anna Grivnin in:Nature Research journals • PubMed • Google ScholarSearch for Yuval Ronen in:Nature Research journals • PubMed • Google

Differentiation of regioisomeric chloroamphetamine analogs using gas chromatography–chemical ionization-tandem mass spectrometry

& Hiroyuki Inoue In recent years, a large number of clandestinely synthesized new psychoactive substances with high structural variety have been detected in forensic samples. Analytical differentiation of

Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively. Using a cell co-culture system, we found that gastric stromal cells secreted IL-6 as a growth and survival factor for gastric cancer cells...

Enhancement of β-xylosidase productivity in cellulase producing fungus Acremonium cellulolyticus

Enzymatic hydrolysis is one of the most important processes in bioethanol production from lignocellulosic biomass. Acremonium cellulolyticus is a filamentous fungus with high cellulase production but productivity of hemicellulase, especially β-xylosidase, is lower than other filamentous fungi. We identified 2.4 Kb β-xylosidase gene in the A. cellulolyticus genome sequence...

Dosimetric and delivery characterizations of full-arc and half-arc volumetric-modulated arc therapy for maxillary cancer

We compared the efficiency and accuracy of full-arc and half-arc volumetric-modulated arc therapy (VMAT) delivery for maxillary cancer. Plans for gantry rotation angles of 360° and 180° (full-arc and half-arc VMAT) were created for six maxillary cancer cases with the Monaco treatment planning system, and delivered using an Elekta Synergy linear accelerator. Full-arc and half-arc...