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Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report

Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic...

Incidence of and risk factors for newly diagnosed hyperkalemia after hospital discharge in non-dialysis-dependent CKD patients treated with RAS inhibitors

this work. Competing interests: Hiroyuki Yamamoto is affiliated with the Department of Healthcare Quality Assessment at the University of Tokyo, and the department is endowed by Johnson & Johnson K. K ... Saito, Hiroyuki Yamamoto, Hideki Nakajima, Osamu Takahashi, Yasuhiro Komatsu. Data curation: Yuki Saito, Hiroyuki Yamamoto, Hideki Nakajima. Formal analysis: Yuki Saito, Hiroyuki Yamamoto, Hideki

Tree growth stress and related problems

, Montpellier , France 1 & Hiroyuki Yamamoto 2 & Joseph Gril 3 Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa , Nagoya 464-8601 , Japan Tree growth stress, resulted from the combined

Association between institutional procedural preference and in-hospital outcomes in laparoscopic surgeries; Insights from a retrospective cohort analysis of a nationwide surgical database in Japan

. Investigation: Hiroaki Miyata. Methodology: Hiroaki Miyata, Hideki Hashimoto, Hiroyuki Yamamoto, Hiraku Kumamaru, Shun Kohsaka, Tadashi Iwanaka. Project administration: Hiroaki Miyata, Tadashi Iwanaka ... . Supervision: Hiroaki Miyata, Masaki Mori, Hideki Hashimoto, Tadashi Iwanaka. Visualization: Hiroyuki Yamamoto, Hiraku Kumamaru. Writing ± original draft: Hiroaki Miyata, Norihiro Kokudo. Writing ± review

Melanin production through novel processing of proopiomelanocortin in the extracellular compartment of the auricular skin of C57BL/6 mice after UV-irradiation

, Ichimaru Pharcos Co. Ltd, 318-1 Asagi, Motosu City, Gifu 501-0475, JapanKiyotaka Tanaka & Arunasiri Iddamalgoda AuthorsSearch for Hiroyuki Yamamoto in:Nature Research journals • PubMed • Google ScholarSearch ... financial interests. Corresponding author Correspondence to Hiroyuki Yamamoto. Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License. The images or

Rhodopsin in the Dark Hot Sea: Molecular Analysis of Rhodopsin in a Snailfish, Careproctus rhodomelas, Living near the Deep-Sea Hydrothermal Vent

Visual systems in deep-sea fishes have been previously studied from a photobiological aspect; however, those of deep-sea fish inhabiting the hydrothermal vents are far less understood due to sampling difficulties. In this study, we analyzed the visual pigment of a deep-sea snailfish, Careproctus rhodomelas, discovered and collected only near the hydrothermal vents of oceans...

Dependence of Microcrack Behavior in Wood on Moisture Content during Drying

; Revised 10 July 2013; Accepted 7 August 2013 Academic Editor: Jeffrey Glass Copyright © 2013 Hiroyuki Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution

Post-Drilling Changes in Seabed Landscape and Megabenthos in a Deep-Sea Hydrothermal System, the Iheya North Field, Okinawa Trough

There has been an increasing interest in seafloor exploitation such as mineral mining in deep-sea hydrothermal fields, but the environmental impact of anthropogenic disturbance to the seafloor is poorly known. In this study, the effect of such anthropogenic disturbance by scientific drilling operations (IODP Expedition 331) on seabed landscape and megafaunal habitation was...

Time dependence of Poisson’s effect in wood III: asymmetry of three-dimensional viscoelastic compliance matrix of Japanese cypress

To understand the viscoelasticity of wood three dimensionally, matched samples of Japanese cypress were loaded in uniaxial tensile creep in the longitudinal (L), radial (R), and tangential (T) directions at approximately 9.7 % equilibrium moisture content. Longitudinal and transverse strains were measured for the determination of viscoelastic Poisson’s ratios and three...

Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

Background Principal component analysis (PCA) has been widely used to visualize high-dimensional metabolomic data in a two- or three-dimensional subspace. In metabolomics, some metabolites (e.g., the top 10 metabolites) have been subjectively selected when using factor loading in PCA, and biological inferences are made for these metabolites. However, this approach may lead to...

Differences in the effects of Asian dust on pulmonary function between adult patients with asthma and those with asthma–chronic obstructive pulmonary disease overlap syndrome

Hisashi Noma,2 Jun Kurai,1 Hiroyuki Sano,3 Yasuto Ueda,1 Masaaki Mikami,4 Hiroyuki Yamamoto,5 Hirokazu Tokuyasu,6 Kazuhiro Kato,7 Tatsuya Konishi,8 Toshiyuki Tatsukawa,8 Eiji Shimizu,1 Hiroya Kitano9 ... hiroyuki Yamamoto 4 Department of respiratory Medicine and r heumatology, Tottori University Faculty of Medicine , 36-1 n ishi-cho, Yonago 5 Department of r espiratory Medicine, s an-in rosai hospital , 1-8

Limited Impact of Passive Non-Neutralizing Antibody Immunization in Acute SIV Infection on Viremia Control in Rhesus Macaques

BackgroundAntiviral antibodies, especially those with neutralizing activity against the incoming strain, are potentially important immunological effectors to control human immunodeficiency virus (HIV) infection. While neutralizing activity appears to be central in sterile protection against HIV infection, the entity of inhibitory mechanisms via HIV and simian immunodeficiency...

The Total Urine Protein-to-Creatinine Ratio Can Predict the Presence of Microalbuminuria

Background The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. The present study aimed to establish a method that predicts the presence of microalbuminuria by measuring the total urine protein-to-creatinine ratio (TPCR) in patients...

Preparation of Polypyrrole by Emulsion Polymerization Using Hydroxypropyl Cellulose

Polypyrrole with particles of uniform diameter was easily obtained from an emulsion of hydroxypropyl cellulose (HPC) and pyrrole by chemical oxidative polymerization, using iron chloride as an oxidizing agent. The particle diameter of the polypyrrole could be controlled by changing the HPC concentration, and it was found that the preparation of water-dispersible polypyrrole was...

Intervalvular fibrosa pseudoaneurysm with projectile shunt flow to left atrium

We report a case of intervalvular fibrosa pseudoaneurysm, causing massive shunt flow from the left ventricle below the left coronary cusp to the left atrium above the anterior mitral annulus, which was clearly demonstrated on preoperative three-dimensional transesophageal echocardiography. Superior extension of the right-sided left atriotomy toward the pseudoaneurysm, combined...

Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation

Tadashi TSUCHIMOTO Koh-ichi SAKATA Masanori SOMEYA Hiroyuki YAMAMOTO Ryoichi HIRAYAMA Yoshihisa MATSUMOTO Yoshiya FURUSAWA Masato HAREYAMA DNA-PK/Gene expression/Hypoxia/Reoxygenation. In order to

Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry

Metabolic microenvironment of tumor cells is influenced by oncogenic signaling and tissue-specific metabolic demands, blood supply, and enzyme expression. To elucidate tumor-specific metabolism, we compared the metabolomics of normal and tumor tissues surgically resected pairwise from nine lung and seven prostate cancer patients, using capillary electrophoresis time-of-flight...

Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk

Background Metachronous gastric cancer (GC) can develop after endoscopic resection of GC and cannot be predicted based on clinical signature. Aberrant DNA methylation in noncancerous gastric mucosa is strongly implicated in gastric carcinogenesis and could be a useful biomarker of GC risk. We evaluated the clinical utility of DNA methylation as a biomarker of metachronous GC risk...

A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins

Background The Gag capsid (CA) is one of the most conserved proteins in highly-diversified human and simian immunodeficiency viruses (HIV and SIV). Understanding the limitations imposed on amino acid sequences in CA could provide valuable information for vaccine immunogen design or anti-HIV drug development. Here, by comparing two pathogenic SIV strains, SIVmac239 and SIVsmE543-3...