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Eumorphus marginatus group in Sulawesi, Indonesia (Coleoptera, Endomychidae)

The species of the Eumorphus marginatus group from Sulawesi are revised. Two previously known species, E. costatus and E. wegneri, are redescribed, and a new species, Eumorphus mirabilis sp. n., is described. A key for identification of these species is provided.

Oriental Hydrocyphon (Coleoptera: Scirtidae: Scirtinae): Seven New Species from Indonesia, Thailand, Malaysia, and India

, Japan Received 29 September 2011; Accepted 27 December 2011 Academic Editor: Brian Forschler Copyright © 2012 Hiroyuki Yoshitomi. This is an open access article distributed under the Creative Commons

Oriental Hydrocyphon (Coleoptera: Scirtidae: Scirtinae): Seven New Species from Indonesia, Thailand, Malaysia, and India

, Japan Received 29 September 2011; Accepted 27 December 2011 Academic Editor: Brian Forschler Copyright © 2012 Hiroyuki Yoshitomi. This is an open access article distributed under the Creative Commons

MCP/CCR2 Signaling Is Essential for Recruitment of Mesenchymal Progenitor Cells during the Early Phase of Fracture Healing

Objective The purpose of this study was to investigate chemokine profiles and their functional roles in the early phase of fracture healing in mouse models. Methods The expression profiles of chemokines were examined during fracture healing in wild-type (WT) mice using a polymerase chain reaction array and histological staining. The functional effect of monocyte chemotactic...

Comprehensive microRNA Analysis Identifies miR-24 and miR-125a-5p as Plasma Biomarkers for Rheumatoid Arthritis

MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify plasma miRNAs specific for rheumatoid arthritis (RA) by a comprehensive array approach. We performed a systematic, array-based miRNA analysis on plasma samples from three RA patients and three healthy controls (HCs). Plasma miRNAs with more...

Periodontitis and Porphyromonas gingivalis in Preclinical Stage of Arthritis Patients

Purpose To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naïve preclinical stage of arthritis patients. Methods We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti...

Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis

Introduction MicroRNAs (miRNAs), endogenous small noncoding RNAs regulating the activities of target mRNAs and cellular processes, are present in human plasma in a stable form. In this study, we investigated whether miRNAs are also stably present in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA...

Stromal Cell-Derived Factor 1 Regulates the Actin Organization of Chondrocytes and Chondrocyte Hypertrophy

Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic and mesenchymal stem cells. This chemokine regulates the formation of multiple organ systems during embryogenesis. However, its roles in skeletal development remain unclear. Here we investigated the roles of SDF-1 in chondrocyte differentiation...

Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis – Analysis Using More than 17,000 Assessments in the KURAMA Database

Rheumatoid arthritis (RA) is a joint-destructive autoimmune disease. Three composite indices evaluating the same 28 joints are commonly used for the evaluation of RA activity. However, the relationship between, and the frequency of, the joint involvements are still not fully understood. Here, we obtained and analyzed 17,311 assessments for 28 joints in 1,314 patients with RA from...

Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis

SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of SKG mice. Two distinct CD8+ clones were established and both...