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Search: authors:"Holly A. Rees"

4 papers found.
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Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks

In mammalian cells, double-stranded DNA breaks (DSBs) are preferentially repaired through end-joining processes that generally lead to mixtures of insertions and deletions (indels) or other rearrangements at the cleavage site. In the presence of homologous DNA, homology-directed repair (HDR) can generate specific mutations, albeit typically with modest efficiency and a low ratio...

Phage-assisted continuous evolution of proteases with altered substrate specificity

, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USAMichael S. Packer, Holly A. Rees & David R. LiuGraduate Program in Biophysics Program, Harvard University, 240 Longwood Avenue, Boston, MA ... , 02115, USAMichael S. PackerBroad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA, 02142, USAMichael S. Packer, Holly A. Rees & David R. LiuHoward Hughes Medical Institute, Harvard University

Structural and evolutionary versatility in protein complexes with uneven stoichiometry

, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UKJoseph A. Marsh, Holly A. Rees & Sarah A. TeichmannTheory of Condensed Matter, Cavendish Laboratory, University ... . Teichmann AuthorsSearch for Joseph A. Marsh in:Nature Research journals • PubMed • Google ScholarSearch for Holly A. Rees in:Nature Research journals • PubMed • Google ScholarSearch for Sebastian E. Ahnert