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Mapping of Adenovirus of serotype 3 fibre interaction to desmoglein 2 revealed a novel ‘non-classical’ mechanism of viral receptor engagement

Mottet Charles Vragniau 0 Hongjie Wang Chloe Zubieta Andr? Lieber Pascal Fender 0 , Corinne Ducournau OPEN High-affinity binding of the trimeric fibre protein to a cell surface primary receptor is a

Effects of Huanglian Jiedu Decoration in Rat Gingivitis

Gingivitis is an inflammatory disease that affects gingival tissues through a microbe-immune interaction. Huanglian Jiedu decoction (HLJD) is used traditionally for clearing and detoxifying in China, which had been reported to possess many pharmacological effects. Rat gingival inflammation model was established by lipopolysaccharide (LPS) injection for 3 consecutive days, and...

Effects of Huanglian Jiedu Decoration in Rat Gingivitis

Gingivitis is an inflammatory disease that affects gingival tissues through a microbe-immune interaction. Huanglian Jiedu decoction (HLJD) is used traditionally for clearing and detoxifying in China, which had been reported to possess many pharmacological effects. Rat gingival inflammation model was established by lipopolysaccharide (LPS) injection for 3 consecutive days, and...

Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression

Reg3g is a potential risk for pancreatic ductal adenocarcinoma (PDAC). We previously demonstrated that Reg3g promoted pancreatic carcinogenesis via a STAT3 signaling pathway in a murine model of chronic pancreatitis. Whether the immune response is involved in tumorigenesis induced by Reg3g remains unknown. In this study, Reg3g-regulated tumor immunity was evaluated in tumor...

Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer’s and Amyotrophic Lateral Sclerosis Brains

32901, USA Received 20 April 2016; Revised 3 June 2016; Accepted 7 June 2016 Academic Editor: Inga Kadish Copyright © 2016 Hongjie Wang et al. This is an open access article distributed under the

Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer’s and Amyotrophic Lateral Sclerosis Brains

Multiple studies suggest that autophagy is strongly dysregulated in Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), as evidenced by accumulation of numerous autophagosomes, lysosomes with discontinuous membranes, and aggregated proteins in the patients’ brains. Transcription factor EB (TFEB) was recently discovered to be a master regulator of lysosome biogenesis...

Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer’s and Amyotrophic Lateral Sclerosis Brains

32901, USA Received 20 April 2016; Revised 3 June 2016; Accepted 7 June 2016 Academic Editor: Inga Kadish Copyright © 2016 Hongjie Wang et al. This is an open access article distributed under the

Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients

Wang Xinbin Shu Jian Yang Nan Si Lingyu Han Haiyu Zhao Baolin Bian OPEN Lepidium meyenii (Maca), originated from Peru, has been cultivated widely in China as a popular health care food. However, the

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy

Chemistry and Pathobiochemistry, Otto-von-Guericke-University, 39120 Magdeburg, GermanyKhurrum Shahzad, Fabian Bock, Moh’d Mohanad Al-Dabet, Ihsan Gadi, Sumra Nazir, Hongjie Wang, Shrey Kohli, Satish Ranjan ... journals • PubMed • Google ScholarSearch for Hongjie Wang in:Nature Research journals • PubMed • Google ScholarSearch for Shrey Kohli in:Nature Research journals • PubMed • Google ScholarSearch for Satish

RanBP9 Overexpression Accelerates Loss of Pre and Postsynaptic Proteins in the APΔE9 Transgenic Mouse Brain

Overexpression Accelerates Loss of Pre and Postsynaptic Proteins in the APDE9 Transgenic Mouse Brain Hongjie Wang 0 Ruizhi Wang 0 Shaohua Xu 0 Madepalli K. Lakshmana 0 William Phillips, University of Sydney

Penton-Dodecahedral Particles Trigger Opening of Intercellular Junctions and Facilitate Viral Spread during Adenovirus Serotype 3 Infection of Epithelial Cells

Human adenovirus serotypes Ad3, Ad7, Ad11, and Ad14 use the epithelial junction protein desmoglein 2 (DSG2) as a receptor for infection. During Ad infection, the fiber and penton base capsid proteins are produced in vast excess and form hetero-oligomers, called pentons. It has been shown for Ad3 that pentons self-assemble into penton-dodecahedra (PtDd). Our previous studies with...

RAGE Controls Activation and Anti-Inflammatory Signalling of Protein C

Aims The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-κB activator leading to perpetuation of inflammation. We investigated whether and how RAGE is involved in mediation of anti-inflammatory properties of protein C. Methods and Results We analyzed the effect of protein C on leukocyte adhesion and transmigration in WT- and RAGE-deficient mice...

Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice

Background The clinical uses of 2-chloro-2′-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and readily passes through the blood brain barrier reaching CSF concentrations 25% of...

Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine

Background Currently available therapies for Alzheimer's disease (AD) do not treat the underlying cause of AD. Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship between cancer and AD. Therefore, we reasoned that oncology drugs may be effective against AD. Methods We screened a library of all the FDA-approved oncology drugs and...

Erythroid Promoter Confines FGF2 Expression to the Marrow after Hematopoietic Stem Cell Gene Therapy and Leads to Enhanced Endosteal Bone Formation

Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1+ hematopoietic stem/progenitor cells that are engineered to express a modified FGF2 leads to considerable endosteal/trabecular bone formation, but it also induces adverse effects like hypocalemia and...

Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban

Preusch,1 Hongjie Wang,1 Berend Isermann,3 Khurrum Shahzad,3 Hugo A. Katus,1 and Erwin Blessing1 1Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany 2Department of

Role of Cellular Heparan Sulfate Proteoglycans in Infection of Human Adenovirus Serotype 3 and 35

Species B human adenoviruses (Ads) are increasingly associated with outbreaks of acute respiratory disease in U.S. military personnel and civil population. The initial interaction of Ads with cellular attachment receptors on host cells is via Ad fiber knob protein. Our previous studies showed that one species B Ad receptor is the complement receptor CD46 that is used by serotypes...

p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth

Muhammed Kashif Andrea Hellwig Alexandre Kolleker Khurrum Shahzad Hongjie Wang SiegfriedLang Juliane Wolter Madhusudhan Thati Ilya Vinnikov Angelika Bierhaus Peter P. Nawroth Berend Isermann

Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes

Dustin Blanton Zhao Han Lindsey Bierschenk M.V. Prasad Linga-Reddy Hongjie Wang Michael Clare-Salzler Michael Haller Desmond Schatz Courtney Myhr Jin-Xiong She Clive Wasserfall Mark Atkinson