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Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice

Honglei Guo,2 and Wei Ding1 1Division of Nephrology, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China 2Division of Nephrology ... , The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), 300 Guangzhou Road, Nanjing, Jiangsu Province 210009, China Correspondence should be addressed to Honglei Guo

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Correspondence should be addressed to Wei Ding; moc.361@5101pmug Received 17 December 2016; Accepted 9 February 2017; Published 28 February 2017 Academic Editor: Tânia Silvia Fröde Copyright © 2017 Honglei Guo ... may offer new insights into the prevention of renal fibrosis in CKD. Competing Interests The authors declare that there is no conflict of interests. Authors’ Contributions Honglei Guo and Xiao Bi

Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury

Aldosterone (Aldo) is critically involved in the development of renal injury via the production of reactive oxygen species and inflammation. Endoplasmic reticulum (ER) stress is also evoked in Aldo-induced renal injury. In the present study, we investigated the role of ER stress in inflammation-mediated renal injury in Aldo-infused mice. C57BL/6J mice were randomized to receive...