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45 papers found.
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Colonization of plant roots and enhanced atrazine degradation by a strain of Arthrobacter ureafaciens

Our previous research found that culturable atrazine degraders associated with maize roots were dominated by genetically similar strains of Arthrobacter ureafaciens, suggesting their rhizosphere competence. The present study aimed to assess the root-colonizing capacity of strain A. ureafaciens DnL1-1 and to evaluate consequent root-associated degradation of atrazine. A soil-sand...

Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens

BackgroundA deletion mutation in the growth hormone receptor (GHR) gene results in the inhibition of skeletal muscle growth and fat deposition in dwarf chickens. We used microarray techniques to determine microRNA (miRNA) and mRNA expression profiles of GHR in the skeletal muscles of 14-day-old embryos as well as 7-week-old deletion-type dwarf and normal-type chickens. Our aim...

Occurrence, diversity and community structure of culturable atrazine degraders in industrial and agricultural soils exposed to the herbicide in Shandong Province, P.R. China

Background Soil populations of bacteria rapidly degrading atrazine are critical to the environmental fate of the herbicide. An enrichment bias from the routine isolation procedure prevents studying the diversity of atrazine degraders. In the present work, we analyzed the occurrence, diversity and community structure of soil atrazine-degrading bacteria based on their direct...

The interactive effect of diabetes and central obesity on stroke: a prospective cohort study of inner Mongolians

Background The relationship between central obesity and stroke is inconsistent in diabetic and non-diabetic populations. This indicates an interaction between diabetes and central obesity on stroke risk. The present study aimed to examine the interaction in a cohort of Inner Mongolians. Methods In this prospective cohort study, we assessed the interaction between diabetes and...

APP physiological and pathophysiological functions: insights from animal models

The amyloid precursor protein (APP) has been under intensive study in recent years, mainly due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) peptides generated from APP proteolytic cleavage can aggregate, leading to plaque formation in human AD brains. Point mutations of APP affecting Aβ production are found to be causal for hereditary early...

β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation

Introduction Caspase activation and cardiomyocyte apoptosis have been implicated in lipopolysaccharide (LPS)-induced cardiac contractile dysfunction. We have recently demonstrated that β1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic mice. Here, we further investigated the molecular mechanisms for the enhancing...

Effects of Insulin Lispro Mix 25 and Insulin Lispro Mix 50 on Postprandial Glucose Excursion in Patients with Type 2 Diabetes: A Prospective, Open-Label, Randomized Clinical Trial

Zhou, Hongmei Li, Yaxiu Dong, and Yuxiu Li have nothing to disclose. Compliance with Ethics Guidelines. All procedures followed were in accordance with the ethical standards of the responsible committee

Contribution of BHG and PPHG to Overall Hyperglycemia in T2DM Patients Treated with LM25 and LM50: Post Hoc Analysis of a Randomized Crossover Trial

study and takes full responsibility for the integrity of the work as a whole, from inception to published article. Disclosures. Wei Li, Hongmei Li, Fan Ping, Lingling Xu, Huabing Zhang, Yaxiu Dong, Qi

Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy

Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM). However, the exact mechanism is not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks...

Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy

Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM). However, the exact mechanism is not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks...

Evolutionary Toxicogenomics: Diversification of the Cyp12d1 and Cyp12d3 Genes in Drosophila Species

Gene duplication and divergence are overwhelmingly considered to be the primary mechanisms by which cytochrome P450 monooxygenases (P450s) have radiated into a large and diverse gene superfamily. To address how environmental stress drives the fixation and diversification of gene duplications, we have analyzed Cyp12d1 and Cyp12d3, a pair of duplicated genes found in the sequenced...

Facile Preparation of Efficient WO3 Photocatalysts Based on Surface Modification

Tungsten trioxide (WO3) was surface modified with Cu(II) nanoclusters and titanium dioxide (TiO2) nanopowders by using a simple impregnation method followed by a physical combining method. The obtained nanocomposites were studied by scanning electron microscope, X-ray photoelectron spectroscopy spectra, UV-visible light spectra, and photoluminescence, respectively. Although the...

Growth of g-C3N4 Layer on Commercial TiO2 for Enhanced Visible Light Photocatalytic Activity

Novel visible light photocatalytic graphitic carbon nitride/TiO2 (g-C3N4/TiO2) composite samples were synthesized by heating mixtures of melamine and commercial TiO2(TO) at different weight ratios. The samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), photoluminescence spectroscopy (PL), Fourier...

Peripheral sympathetic mechanisms in orofacial pain

Peripheral sympathetic mechanisms in orofacial pain Wenguo Fan,1,2 Xiao Zhu,3 Yifan He,1 Hongmei Li,4 Wenzhen Gu,1 Fang Huang,1 Hongwen He1 1Institute of Stomatological Research, Sun Yat-sen

Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury

Aldosterone (Aldo) is critically involved in the development of renal injury via the production of reactive oxygen species and inflammation. Endoplasmic reticulum (ER) stress is also evoked in Aldo-induced renal injury. In the present study, we investigated the role of ER stress in inflammation-mediated renal injury in Aldo-infused mice. C57BL/6J mice were randomized to receive...

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

Background Accumulation and deposition of β-amyloid peptides (Aβ) in the brain is a central event in the pathogenesis of Alzheimer’s disease (AD). Besides the parenchymal pathology, Aβ is known to undergo active transport across the blood–brain barrier and cerebral amyloid angiopathy (CAA) is a prominent feature in the majority of AD. Although impaired cerebral blood flow (CBF...

Carboxymethyl chitosan-folic acid-conjugated Fe3O4@SiO2 as a safe and targeting antitumor nanovehicle in vitro

A synthetic method to prepare a core-shell-structured Fe3O4@SiO2 as a safe nanovehicle for tumor cell targeting has been developed. Superparamagnetic iron oxide is encapsulated inside nonporous silica as the core to provide magnetic targeting. Carboxymethyl chitosan-folic acid (OCMCS-FA) synthesized through coupling folic acid (FA) with OCMCS is then covalently linked to the...

TrueSight: a new algorithm for splice junction detection using RNA-seq

RNA-seq has proven to be a powerful technique for transcriptome profiling based on next-generation sequencing (NGS) technologies. However, due to the short length of NGS reads, it is challenging to accurately map RNA-seq reads to splice junctions (SJs), which is a critically important step in the analysis of alternative splicing (AS) and isoform construction. In this article, we...

Na+/H+ exchanger (NHE) in Pacific white shrimp (Litopenaeus vannamei): Molecular cloning, transcriptional response to acidity stress, and physiological roles in pH homeostasis

Conceptualization: Chunhua Ren. Data curation: Hongmei Li, Ting Chen. Formal analysis: Hongmei Li, Ting Chen. Funding acquisition: Xiao Jiang, Wen Huang, Ting Chen, Chaoqun Hu. Investigation: Yao Ruan, Xin Zhang ... . Methodology: Ting Chen. Project administration: Chunhua Ren, Xiao Jiang, Chaoqun Hu. Resources: Xiao Jiang, Chuhang Cheng, Xin Zhang, Wen Huang. Supervision: Chaoqun Hu. Writing ? original draft: Hongmei Li