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ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

inhibits colon cancer cell proliferation and tumour growth Notes Sheng Zhou, Hongwei Xia and Huanji Xu contributed equally to this work. Abbreviations AKT:  Protein kinase B CytC:  Cytochrome c

Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation

Acetylcholine (ACh), known as a neurotransmitter, regulates the functions of numerous fundamental central and peripheral nervous system. Recently, emerging evidences indicate that ACh also plays an important role in tumorigenesis. However, little is known about the role of ACh in gastric cancer. Here, we reported that ACh could be auto-synthesized and released from MKN45 and...

New Results on Stability and Stabilization of Markovian Jump Systems with Time Delay

; Accepted 21 June 2014; Published 3 August 2014 Academic Editor: Ligang Wu Copyright © 2014 Hongwei Xia et al. This is an open access article distributed under the Creative Commons Attribution License

New Results on Stability and Stabilization of Markovian Jump Systems with Time Delay

; Accepted 21 June 2014; Published 3 August 2014 Academic Editor: Ligang Wu Copyright © 2014 Hongwei Xia et al. This is an open access article distributed under the Creative Commons Attribution License

New Results on Stability and Stabilization of Markovian Jump Systems with Time Delay

; Accepted 21 June 2014; Published 3 August 2014 Academic Editor: Ligang Wu Copyright © 2014 Hongwei Xia et al. This is an open access article distributed under the Creative Commons Attribution License

A Novel Approach to Sliding Mode Control of Time-Delay Systems

Technology, Shenzhen 518055, China Received 9 June 2013; Revised 29 August 2013; Accepted 29 August 2013 Academic Editor: Rongni Yang Copyright © 2013 Hongwei Xia et al. This is an open access article

A Novel Approach to Sliding Mode Control of Time-Delay Systems

Technology, Shenzhen 518055, China Received 9 June 2013; Revised 29 August 2013; Accepted 29 August 2013 Academic Editor: Rongni Yang Copyright © 2013 Hongwei Xia et al. This is an open access article

A Novel Approach to Control Design for Linear Neutral Time-Delay Systems

Institute of Technology at Weihai, Weihai 264200, China Received 2 February 2013; Accepted 24 February 2013 Academic Editor: Ligang Wu Copyright © 2013 Hongwei Xia et al. This is an open access article

A Novel Approach to Control Design for Linear Neutral Time-Delay Systems

Institute of Technology at Weihai, Weihai 264200, China Received 2 February 2013; Accepted 24 February 2013 Academic Editor: Ligang Wu Copyright © 2013 Hongwei Xia et al. This is an open access article

Novel Split-Luciferase-Based Genetically Encoded Biosensors for Noninvasive Visualization of Rho GTPases

Rho family GTPases are critical regulators of many important cellular processes and the dysregulation of their activities is implicated in a variety of human diseases including oncogenesis and propagation of malignancy. The traditional methods, such as “pull-down” or two-hybrid procedures, are poorly suited to dynamically evaluate the activity of Rho GTPases, especially in living...