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Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

, Ren-Hua Chung, Chia-Lung Shih, Hsiang-Wei Kuo. Formal analysis: Tung-Hsia Liu, Chia-Lung Shih. Investigation: Sheng-Chang Wang. Methodology: Ren-Hua Chung, Chiu-Ping Fang, Hsiang-Wei Kuo. Software ... : Tung-Hsia Liu, Ren-Hua Chung, Chia-Lung Shih. Supervision: Ren-Hua Chung, Yu-Li Liu. Validation: Hsiao-Hui Tsou. Visualization: Tung-Hsia Liu, Hsiang-Wei Kuo. Writing ± original draft: Tung-Hsia Liu

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may...

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients. A steady-state plasma concentration of methadone enantiomers, a measure of methadone metabolism, is an index of treatment response and efficacy of MMT. Although the methadone metabolism pathway...

Hepatitis C Virus Infection Influences the S-Methadone Metabolite Plasma Concentration

Background and Objectives Heroin-dependent patients typically contract hepatitis C virus (HCV) at a disproportionately high level due to needle exchange. The liver is the primary target organ of HCV infection and also the main organ responsible for drug metabolism. Methadone maintenance treatment (MMT) is a major treatment regimen for opioid dependence. HCV infection may affect...