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Discovering Hierarchical Subgraphs of K-Core-Truss

Kongque Program (827/000065), and Beijing Institute of Technology Research Fund Program for Young Scholars. Dr. Rong-Hua Li is a corresponding author of this paper. Open Access This article is distributed

Fabrication of Microlens Array and Its Application: A Review

processing and robotics. Li‑Hua Li born in 1981, is current a research assistant at State Key Laboratory of Ultra-precision Machining Technology, the Hong Kong Polytechnic University, China. She earned her PhD

Prediction of Thromboembolic Events in Heart Failure Patients in Sinus Rhythm: The Hong Kong Heart Failure Registry

Aim Heart failure (HF) increases the risk of thromboembolic events (TE). Study in a Caucasian population has shown that the CHA2DS2-VASc score predicts TE among HF patients without atrial fibrillation. We sought to assess the usefulness of the CHA2DS2-VASc score in predicting TE in an Asian population and refine the scoring system to improve its predictability of TE among HF...

Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease

Background Little is known about whether atrial fibrillation is a presentation of coronary disease. There is a paucity of knowledge about their causal relationship and also the impact of different antithrombotic strategies on the subsequent presentation of symptomatic coronary disease. Methods and Results We studied 7,526 Chinese patients diagnosed with non-valvular atrial...

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

Background Protein tyrosine phosphatase receptor type D (PTPRD) is a putative tumor suppressor in several cancers including head and neck squamous cell carcinoma (HNSCC). STAT3 is a frequently hyperactivated oncogene in HNSCC. As STAT3 is a direct substrate of PTPRD, we sought to determine the genetic or epigenetic alterations of PTPRD that contribute to overactive STAT3 in HNSCC...

Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence

Background The efficacy and safety of warfarin therapy for stroke prevention in atrial fibrillation (AF) depends on the time in therapeutic range (TTR). We aimed to assess the predictive ability of SAMe-TT2R2 score in Chinese AF patients on warfarin, whose TTR is notoriously poor. Methods and Results This is a single-centre retrospective study. Patients with non-valvular AF on...

Evolution of Cooperation in Spatial Traveler's Dilemma Game

Traveler's dilemma (TD) is one of social dilemmas which has been well studied in the economics community, but it is attracted little attention in the physics community. The TD game is a two-person game. Each player can select an integer value between and () as a pure strategy. If both of them select the same value, the payoff to them will be that value. If the players select...

A Framework of Algorithms: Computing the Bias and Prestige of Nodes in Trust Networks

A trust network is a social network in which edges represent the trust relationship between two nodes in the network. In a trust network, a fundamental question is how to assess and compute the bias and prestige of the nodes, where the bias of a node measures the trustworthiness of a node and the prestige of a node measures the importance of the node. The larger bias of a node...

Validation of NINDS-CSN neuropsychological battery for vascular cognitive impairment in Chinese stroke patients

Background The NINDS-Canadian Stroke Network (NINDS-CSN) recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment (VCI), however, due to culture and language differences, the battery cannot be directly used in China. Validation of the battery in mandarin Chinese is lacking. Our study investigated the reliability and validity of the...

High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells

for diabetes, the rapid growth in biomedical tools globally should allow the further development of a better ESC differentiation strategy for diabetes. Author contribution Hua LI: collection and

Association of Caucasian-Identified Variants with Colorectal Cancer Risk in Singapore Chinese

Background Genome-wide association studies (GWAS) in Caucasians have identified fourteen index single nucleotide polymorphisms (iSNPs) that influence colorectal cancer (CRC) risk. Methods We investigated the role of eleven iSNPs or surrogate SNPs (sSNPs), in high linkage disequilibrium (LD, r2≥0.8) and within 100 kb vicinity of iSNPs, in 2,000 age- and gender-matched Singapore...

The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential

Hai Yong Chen Xiao R. Huang Wansheng Wang Jin Hua Li Rainer L. Heuchel Arthur C.K. Chung Hui Yao Lan OBJECTIVE-Although Smad3 has been considered as a downstream mediator of transforming growth

Calycosin Promotes Angiogenesis Involving Estrogen Receptor and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC

Background Angiogenesis plays an important role in a wide range of physiological processes, and many diseases are associated with the dysregulation of angiogenesis. Radix Astragali is a Chinese medicinal herb commonly used for treating cardiovascular disorders and has been shown to possess angiogenic effect in previous studies but its active constituent and underlying mechanism...

Trends in incidence and mortality of nasopharyngeal carcinoma over a 20–25 year period (1978/1983–2002) in Sihui and Cangwu counties in southern China

Background Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world but is common in southern China. A recent report from the Hong Kong Cancer Registry, a high-risk area for NPC in southern China, showed that incidence rate decreased by 29% for males and by 30% for females from 1980–1999, while mortality rate decreased by 43% for males and 50% for females...