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Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells

BackgroundAutologous cultivated oral mucosal epithelial transplantation (COMET) is an important treatment for limbal stem cell deficiency. However, peripheral corneal neovascularization after surgery hinders its application. This study aims to employ a culture system using allogenic limbal niche cells (LNCs) instead of mouse-derived 3T3 cells as a feeder layer that could relieve...

Rat limbal niche cells can induce transdifferentiation of oral mucosal epithelial cells into corneal epithelial-like cells in vitro

Cultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal microenvironment, limbal niche cells (LNCs) play a key role in the direction of stem cell differentiation. In this study, we investigated whether LNCs can induce the...

Rat limbal niche cells can induce transdifferentiation of oral mucosal epithelial cells into corneal epithelial-like cells in vitro

BackgroundCultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal microenvironment, limbal niche cells (LNCs) play a key role in the direction of stem cell differentiation. In this study, we investigated whether LNCs can induce...

Characterization of Ex Vivo Expanded Oral Mucosal Epithelium Cells on Acellular Porcine Corneal Stroma for Ocular Surface Reconstruction

collection and assembly of data, data analysis and interpretation, and manuscript writing. Hua-Tao Xie was responsible for the conception and design of the study and manuscript writing. Ming-Chang Zhang was

Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles

significant alternative for corneal reconstruction. Conflicts of Interest The authors indicate no potential conflict of interest. Authors? Contributions Hua-Tao Xie and Dan Zhao contributed equally to this

Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles

Copyright © 2017 Hua-Tao Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... Hua-Tao Xie and Dan Zhao contributed equally to this work. Acknowledgments This work was supported by the National Natural Science Foundation of China (Grant nos. 81300736 and 81370993). References