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Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Efficient and site-specific chemical modification of proteins under physiological conditions remains a challenge. Here we report that 1,4-dinitroimidazoles are highly efficient bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. Under acidic to neutral aqueous conditions, 1,4-dinitroimidazoles react specifically with cysteines via a...

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its...

MicroRNA-1253 suppresses cell proliferation and invasion of non-small-cell lung carcinoma by targeting WNT5A

People’s Hospital, Tangshan, 063000, ChinaMeiyue Liu, Chao Zhang, Zhao Yang, Yi Niu, Huan Wang, Xiaomei Wei, Wei Wang, Peng Gao & Guogui SunDepartment of Nuclear Medicine, The Second Hospital of Tianjin ... • Google Scholar Search for Yi Niu in:Nature Research journals • PubMed • Google Scholar Search for Huan Wang in:Nature Research journals • PubMed • Google Scholar Search for Xiaomei Wei in:Nature Research

A SPR biosensor based on signal amplification using antibody-QD conjugates for quantitative determination of multiple tumor markers

The detection of tumor markers is very important in early cancer diagnosis; however, tumor markers are usually present at very low concentrations, especially in the early stages of tumor development. Surface plasmon resonance (SPR) is widely used to detect biomolecular interactions; it has inherent advantages of being high-throughput, real-time, and label-free technique. However...

Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction

Yung-Lin Hsieh Nandita M. Naik Szu-Huan Wang Iksoo Chang Hsiu-Ming Shih Tai-Huang Huang OPEN The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of

Angular dependent anisotropic terahertz response of vertically aligned multi-walled carbon nanotube arrays with spatial dispersion

of Physics, Northwest University, Xi’an 710069, ChinaYixuan Zhou, Xinlong Xu, Weilong Li, Huan Wang, Lipeng Zhu, Jintao Bai & Zhaoyu RenInstitute of Physics, Chinese Academy of Sciences, Beijing 100190 ... in:Nature Research journals • PubMed • Google ScholarSearch for Weilong Li in:Nature Research journals • PubMed • Google ScholarSearch for Huan Wang in:Nature Research journals • PubMed • Google ScholarSearch

Brain protection against ischemic stroke using choline as a new molecular bypass treatment

, analyzed the data, and wrote the manuscript; Ru-huan WANG conducted some of the experiments; and Chao-liang LONG and Hui WANG participated in discussions and writing the manuscript. Abbreviations nAChR

Lateralization of gene expression in the honeybee brain during olfactory learning

In the last decade, it has been demonstrated that brain functional asymmetry occurs not only in vertebrates but also in invertebrates. However, the mechanisms underlying functional asymmetry remain unclear. In the present study, we trained honeybees of the same parentage and age, on the proboscis extension reflex (PER) paradigm with only one antenna in use. The comparisons of...

Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

, and Xin-ling DU designed the study; Huan WANG, Hao ZHANG, Chen WANG, and Yu-fang CHEN performed the experiments; Huan WANG and Rong MA analyzed the data; Hong-fei WANG, Chen WANG, and Yu-fang CHEN ... provided the reagents and materials; and Huan WANG, Hong-fei WANG, and Qiang TANG wrote the paper. References 1. Kleber AG, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated

LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer

Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation of lncRNAs is involved in the progression of many types of cancer, including epithelial ovarian cancer (EOC). To explore the potential roles of lncRNAs in EOC, we performed lncRNA and mRNA microarray profiling in malignant EOC, benign ovarian cyst and healthy control tissues...

Selectively enhanced photocurrent generation in twisted bilayer graphene with van Hove singularity

Graphene with ultra-high carrier mobility and ultra-short photoresponse time has shown remarkable potential in ultrafast photodetection. However, the broad and weak optical absorption (∼2.3%) of monolayer graphene hinders its practical application in photodetectors with high responsivity and selectivity. Here we demonstrate that twisted bilayer graphene, a stack of two graphene...

Re-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses

200241, ChinaGeng Chen, Jiwei Chen, Ruifang Cao, Juan Yang, Huan Wang, Xiangjun Ji & Tieliu ShiNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USADianke Yu ... • Google ScholarSearch for Juan Yang in:Nature Research journals • PubMed • Google ScholarSearch for Huan Wang in:Nature Research journals • PubMed • Google ScholarSearch for Xiangjun Ji in:Nature Research

Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn’s disease patients

Wang Xu Chen Yuan-Sheng Liu Ping Li Ying Shi Yong-Zhan Nie Shao Li Kai-Chun Wu Zhan-Ju Liu Jian-Lin Ren Bayasi Guleng Scientific RepoRts OPEN Previous studies have highlighted the role of genetic

The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function

Aim:To investigate the effects of iptakalim on endothelial dysfunction induced by insulin resistance (IR) and to determine whether iptakalim improved IR associated with hypertension in fructose-fed rats (FFRs) and spontaneously hypertensive rats (SHRs).Methods:Human umbilical vein endothelial cells (HUVECs) were used for in vitro study. The levels of endothelial vasoactive...

Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy

Ji-Yuan Zhang Hong-Wei Yu Yu-Lan He Jing-Jing Zhao Juan Li Yue-Ke Zhu Qin-Wei Yao Jin-Huan Wang Hai-Xia Liu Shu-Yun Shi Zheng-Sheng Zou Xiang-Sheng Xu Chun-Bao Zhou Fu-Sheng Wang Qing-Hua Meng Acute