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A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously...

A Novel Role of CDX1 in Embryonic Epicardial Development

The molecular mechanism that regulates epicardial development has yet to be understood. In this study, we explored the function of CDX1, a Caudal-related family member, in epicardial epithelial-to-mesenchymal transition (EMT) and in the migration and the differentiation of epicardium-derived progenitors into vascular smooth muscle cells. We detected a transient expression of CDX1...

A SPR biosensor based on signal amplification using antibody-QD conjugates for quantitative determination of multiple tumor markers

The detection of tumor markers is very important in early cancer diagnosis; however, tumor markers are usually present at very low concentrations, especially in the early stages of tumor development. Surface plasmon resonance (SPR) is widely used to detect biomolecular interactions; it has inherent advantages of being high-throughput, real-time, and label-free technique. However...

A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro

Aromatase is a key enzyme involved in estradiol and estrone biosynthesis. Given that polymorphisms of the CYP19A1 gene encoding aromatase have been correlated with plasma testosterone levels, CYP19A1 may therefore act as a genetic modifier of the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS). However, no functional CYP19A1 polymorphisms that predict the risk of...

A new conservative nonlinear high-order compact finite difference scheme for the general Rosenau-RLW equation

In this paper, a new conservative high-order compact finite difference scheme is studied for the initial-boundary value problem of the generalized Rosenau-regularized long wave equation. We design new conservative nonlinear fourth-order compact finite difference schemes. It is proved by the discrete energy method that the compact scheme is uniquely solvable; we have the energy...

A note on the optimality condition for a bilevel programming

The equality type Mordukhovich coderivative rule for a solution mapping to a second-order cone constrained parametric variational inequality is derived under the constraint nondegenerate condition, which improves the result published recently. The rule established is then applied to deriving a necessary and sufficient local optimality condition for a bilevel programming with a...

A robust estimator of parameters for \( {\mathcal{G}}_I^0 \) -modeled SAR imagery based on random weighting method

perform the analysis with constructive discussions and revised the manuscript; X-BW and H-XX approved the final version. All authors read and approved the final manuscript. Authors’ information Cui-Huan ... Wang received the B.S. degree in Communication Engineering from North College of Beijing University of Chemical Technology, Hebei, China, in 2014. Currently, she is pursuing her master’s degree in

A time series of urban extent in China using DSMP/OLS nighttime light data

S1 File. The time series of urban extent in China underlying the findings described in manuscript. (ZIP) (ZIP) S2 File. The raw files of all figures contained in manuscript. Data curation: Huan Wang

ABT-737 Induces Bim Expression via JNK Signaling Pathway and Its Effect on the Radiation Sensitivity of HeLa Cells

ABT-737 is a BH3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic Bcl-2 family proteins including Bcl2, Bcl-xL and Bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-Bid, Bad, Bim). In this study, we demonstrate that ABT-737 improved the radiation sensitivity of cervical cancer HeLa cells and...

Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176

The limited symptom relief and side effects of current Alzheimer’s disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The “cholinergic hypothesis” of AD prompts us to search for plant-derived acetylcholineesterase (AChE) inhibitors such as galanthamine that has been licensed in Europe for AD treatment. We used the unique amyloid β-expressing...

Amperometric Formaldehyde Sensor Based on a Pd Nanocrystal Modified C/Co2P Electrode

12 November 2017 Academic Editor: C. R. Raj Copyright © 2017 Huan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted

An Enhanced Supervisory Control Strategy for Periodicity Mutual Exclusions in Discrete Event Systems Based on Petri Nets

Mutual exclusion problems widely exist in discrete event systems in which several processes will compete for the common resource for maintaining their normal running. This competition is mutually exclusive. However, a special behavior, that is, periodic mutual exclusion behavior, is important for many discrete event systems. Once a process obtains the common resource, it will...

Angular dependent anisotropic terahertz response of vertically aligned multi-walled carbon nanotube arrays with spatial dispersion

of Physics, Northwest University, Xi’an 710069, ChinaYixuan Zhou, Xinlong Xu, Weilong Li, Huan Wang, Lipeng Zhu, Jintao Bai & Zhaoyu RenInstitute of Physics, Chinese Academy of Sciences, Beijing 100190 ... in:Nature Research journals • PubMed • Google ScholarSearch for Weilong Li in:Nature Research journals • PubMed • Google ScholarSearch for Huan Wang in:Nature Research journals • PubMed • Google ScholarSearch

Apoptosis and necrosis induced by novel realgar quantum dots in human endometrial cancer cells via endoplasmic reticulum stress signaling pathway

Apoptosis and necrosis induced by novel realgar quantum dots in human endometrial cancer cells via endoplasmic reticulum stress signaling pathway Huan Wang,1–3 Zhengyun Liu,4 Ying Gou,3 Yu Qin,4 Yaze

Are There Any Different Effects of Bifidobacterium, Lactobacillus and Streptococcus on Intestinal Sensation, Barrier Function and Intestinal Immunity in PI-IBS Mouse Model?

Background and Aims Research has increasingly suggested that gut flora plays an important role in the development of post-infectious irritable bowel syndrome (PI-IBS). Studies of the curative effect of probiotics for IBS have usually been positive but not always. However, the differences of treatment effects and mechanisms among probiotic stains, or mixture of them, are not clear...

AtPID: a genome-scale resource for genotype–phenotype associations in Arabidopsis

AtPID (Arabidopsis thaliana Protein Interactome Database, available at is an integrated database resource for protein interaction network and functional annotation. In the past few years, we collected 5564 mutants with significant morphological alterations and manually curated them to 167 plant ontology (PO) morphology categories. These single...

Big effects of small RNAs on legume root biotic interactions

Comprehensive profiling of microRNAs (miRNAs) from the legume Medicago truncatula reveals the organization of miRNA-based regulatory modules in root biotic interactions.

Binding Patterns of Rotavirus Genotypes P[4], P[6], and P[8] in China with Histo-Blood Group Antigens

Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P...