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UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian

This study developed an ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection of three major metabolites of mequindox, including 3-methyl-quinoxaline-2-carboxylic acid, 1-desoxymequindox, and 1,4-bisdesoxymequindox (MQCA, 1-DMEQ, and BDMEQ), in holothurian. Target analytes were simplified with ultrasound-assisted acidolysis...

UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian

This study developed an ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection of three major metabolites of mequindox, including 3-methyl-quinoxaline-2-carboxylic acid, 1-desoxymequindox, and 1,4-bisdesoxymequindox (MQCA, 1-DMEQ, and BDMEQ), in holothurian. Target analytes were simplified with ultrasound-assisted acidolysis...

Perfectly matched 20-nucleotide guide RNA sequences enable robust genome editing using high-fidelity SpCas9 nucleases

High-fidelity SpCas9 variants (eSpCas9 and SpCas9-HF1) have been engineered to reduce off-target effects. We found that changes in guide RNA length induced significant reductions in the editing activities of SpCas9 variants in plant cells. Single guide RNAs harboring precise, perfectly matched 20-nucleotide guide sequences are necessary for high on-target editing activities of...

Photoelectrochemical Properties of CuS-GeO2-TiO2 Composite Coating Electrode

The ITO (indium tin oxide) conductive glass-matrix CuS-GeO2-TiO2 composite coating was generated via EPD (electrophoretic deposition) and followed by a sintering treatment at 450°C for 40 minutes. Characterizations of the CuS-GeO2-TiO2 composite coating were taken by SEM (scanning electron microscope), XRD (X-ray diffraction), EDX (energy dispersive X-ray), UV-Vis DRS...

Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes

Substantial efforts are being made to optimize the CRISPR/Cas9 system for precision crop breeding. The avoidance of transgene integration and reduction of off-target mutations are the most important targets for optimization. Here, we describe an efficient genome editing method for bread wheat using CRISPR/Cas9 ribonucleoproteins (RNPs). Starting from RNP preparation, the whole...

Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І

Background Japanese encephalitis (JE) is an arboviral disease with high case fatality rates and neurologic or psychiatric sequelae among survivors in Asia, western Pacific countries and northern Australia. Japanese encephalitis virus (JEV) is the cause of JE and the emergence of genotype І (GI) JEV has displaced genotype III (GIII) as the dominant strains circulating in some...

Concentration and detection of tobacco etch virus from irrigation water using real-time PCR

Irrigation water can be polluted by the tobacco etch virus (TEV), which causes serious economic loss in tobacco. However, it is difficult to monitor the sanitary status of irrigation water because TEV presents at extremely low concentrations. This study designed a procedure for concentrating TEV from a standard water sample using polyethylene glycol and detecting it using SYBR...

ABSCISIC ACID-INSENSITIVE 4 negatively regulates flowering through directly promoting Arabidopsis FLOWERING LOCUS C transcription

During the life cycle of a plant, one of the major biological processes is the transition from the vegetative to the reproductive stage. In Arabidopsis, flowering time is precisely controlled by extensive environmental and internal cues. Gibberellins (GAs) promote flowering, while abscisic acid (ABA) is considered as a flowering suppressor. However, the detailed mechanism through...

Corrigendum to “Ethyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy”

, Lei He, Ping Cheng, Yan Zhang, Chengfen Wang, Dong Wu, Jing Yang, Rong Zhu, Huawei Zhang, Yingqun Zhou, and Chuanyong Guo Department of Gastroenterology, The Tenth People’s Hospital of Tongji

Magnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder

AffiliationsHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaZiqi Chen, Huawei Zhang, Zhiyun Jia, Xiaoqi Huang, Mingying Du, Lizhou Chen & Qiyong ... ScholarSearch for Huawei Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Zhiyun Jia in:Nature Research journals • PubMed • Google ScholarSearch for Jingjie Zhong in:Nature Research journals

Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice

Yang, Qin Yin, Huawei Zhang, Junshan Wang, Jie Lu, Yingqun Zhou, and Chuanyong Guo Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University of Medicine, Shanghai 200072, China

Hierarchical fragmentation and differential star formation in the Galactic ‘Snake’: infrared dark cloud G11.11−0.12

We present Submillimeter Array (SMA) λ = 0.88 and 1.3 mm broad-band observations, and Very Large Array (VLA) observations in NH3 (J, K) = (1,1) up to (5,5), H2O and CH3OH maser lines towards the two most massive molecular clumps in infrared dark cloud (IRDC) G11.11−0.12. Sensitive high-resolution images reveal hierarchical fragmentation in dense molecular gas from the ∼1 pc clump...

ABI4 Regulates Primary Seed Dormancy by Regulating the Biogenesis of Abscisic Acid and Gibberellins in Arabidopsis

Seed dormancy is an important economic trait for agricultural production. Abscisic acid (ABA) and Gibberellins (GA) are the primary factors that regulate the transition from dormancy to germination, and they regulate this process antagonistically. The detailed regulatory mechanism involving crosstalk between ABA and GA, which underlies seed dormancy, requires further elucidation...

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway

Background Hepatic ischemia–reperfusion injury (HIRI) remains a pivotal clinical problem after hemorrhagic shock, transplantation, and some types of toxic hepatic injury. Apoptosis and autophagy play important roles in cell death during HIRI. It is also known that N-acetylcysteine (NAC) has significant pharmacologic effects on HIRI including elimination of reactive oxygen species...

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy

Aberrant transcriptional regulation contributes to the pathogenesis of both congenital and adult forms of liver disease. Although the transcription factor RBPJ is essential for liver morphogenesis and biliary development, its specific function in the differentiation of hepatic progenitor cells (HPC) has not been investigated, and little is known about its role in adult liver...

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis Ping Cheng,* Kan Chen,* Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Chengfen Wang, Jing Yang, Rong Zhu, Huawei

Erratum to “15-Deoxy-12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR and Reduction in NF-B Activity”

 Jingjing Li,1 Junshan Wang,1 Yujing Xia,1 Weiqi Dai,1 Fan Wang,1 Miao Shen,1 Ping Cheng,1 Yan Zhang,1 Chengfen Wang,1 Jing Yang,1 Rong Zhu,1 Huawei Zhang,1 Yuanyuan Zheng,1 Jie Lu,1 Zhuoyi Fan,2 Yingqun Zhou

Erratum to “15-Deoxy-12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR and Reduction in NF-B Activity”

,1 Junshan Wang,1 Yujing Xia,1 Weiqi Dai,1 Fan Wang,1 Miao Shen,1 Ping Cheng,1 Yan Zhang,1 Chengfen Wang,1 Jing Yang,1 Rong Zhu,1 Huawei Zhang,1 Yuanyuan Zheng,1 Jie Lu,1 Zhuoyi Fan,2 Yingqun Zhou,1

Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways

 Chengfen Wang,1 Jingjing Li,1 Jing Yang,1 Rong Zhu,1,3 Huawei Zhang,1,4 Yuanyuan Zheng,1 Jie Lu,1 Yingqun Zhou,1 and Chuanyong Guo1 1Department of Gastroenterology, The Tenth People’s Hospital of Tongji

Hydrogen Sulfide Ameliorates Ischemia/Reperfusion-Induced Hepatitis by Inhibiting Apoptosis and Autophagy Pathways

 Chengfen Wang,1 Jingjing Li,1 Jing Yang,1 Rong Zhu,1,3 Huawei Zhang,1,4 Yuanyuan Zheng,1 Jie Lu,1 Yingqun Zhou,1 and Chuanyong Guo1 1Department of Gastroenterology, The Tenth People’s Hospital of Tongji