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Perinatal and childhood risk factors for early-onset type 1 diabetes: a population-based case-control study in Taiwan

Hui-Fang Su 4 Chung-Yi Li 2 3 0 Department of Endocrinology, Far-Eastern Memorial Hospital , New Taipei City , Taiwan 1 Department of Medical Research, Ditmanson Medical Foundation, Chia-Yi Christian

When is Cancer Care Cost-Effective? A Systematic Overview of Cost–Utility Analyses in Oncology

New cancer treatments pose a substantial financial burden on health-care systems, insurers, patients, and society. Cost–utility analyses (CUAs) of cancer-related interventions have received increased attention in the medical literature and are being used to inform reimbursement decisions in many health-care systems. We identified and reviewed 242 cancer-related CUAs published...

Genome-wide association study of Parkinson’s disease in East Asians

Zhong Pei 9 22 Rong Peng 6 22 Hui-Fang Shang 6 22 Kyuyoung Song 7 22 Ai Huey Tan 13 22 Yih-Ru Wu 14 22 Tin Aung 4 5 22 Ching-Yu Cheng 1 4 5 22 Fook Tim Chew 3 22 Soo-Hong Chew 0 22 Siow-Ann Chong 21 22

Prognostic Impact of Vascular Endothelial Growth Factor-A and E-Cadherin Expression in Completely Resected Pathologic Stage I Non-Small Cell Lung Cancer

The purpose of this study was to evaluate the value of vascular endothelial growth factor-A and E-cadherin expression as well as other confirmed prognostic factors in predicting the clinical outcome after definitive surgery of pathologic stage I non-small cell lung cancer.

Brugia malayi Asparaginyl–Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes and Activates G-Protein–Coupled Receptors CXCR1 and CXCR2

BackgroundLymphatic filariasis is a chronic human parasitic disease in which the parasites repeatedly provoke acute and chronic inflammatory reactions in the host bloodstream and lymphatics. Excretory-secretory products derived from filariae are believed to play an important role in the development of associated immunologic conditions; however, the specific mechanisms involved in...

Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1

The pancreatic and duodenal homeobox factor-1 (Pdx1) is essential for pancreatic development and insulin gene transcription, whereas c-Myc has a deleterious effect on islet function. However, the relationship between c-Myc and Pdx1 is poorly concerned. Here we demonstrated that Pdx1 could suppress c-Myc promoter activity, which relied on T cell factor (Tcf) binding elements...

Pre-clinical Experimental Therapeutics and Pharmacology

, whereas IA plus BBBD should increase the tumor uptake. ET-09. BRAF TARGETED THERAPY IN BRAF V600E MUTANT GLIOBLASTOMA INTRACRANIAL XENOGRAFTS Hui-Fang Li 1, Rintaro Hashizume 2, Yasuyuki Aoki 2, Sujatmi ... INHIBITOR COMBINATION THERAPIES FOR ASSESSING POTENTIAL TREATMENT STRATEGIES FOR NEWLY DIAGNOSED GBM Karine Michaud 1, David A. Solomon 2, Hui-Fang Li 2, Jung-Sik Kim 2, Michael D. Prados 1, Tomoko Ozawa 1