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Pre-clinical Experimental Therapeutics and Pharmacology

, whereas IA plus BBBD should increase the tumor uptake. ET-09. BRAF TARGETED THERAPY IN BRAF V600E MUTANT GLIOBLASTOMA INTRACRANIAL XENOGRAFTS Hui-Fang Li 1, Rintaro Hashizume 2, Yasuyuki Aoki 2, Sujatmi ... INHIBITOR COMBINATION THERAPIES FOR ASSESSING POTENTIAL TREATMENT STRATEGIES FOR NEWLY DIAGNOSED GBM Karine Michaud 1, David A. Solomon 2, Hui-Fang Li 2, Jung-Sik Kim 2, Michael D. Prados 1, Tomoko Ozawa 1

Increased expression of non-sulfated chondroitin correlates with adverse clinicopathological parameters in prostate cancer

. Author information AffiliationsDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeYvonne Hui-Fang Teng, Puay-Hoon Tan, Boon-Huat Bay & George Wai-Cheong ... Yvonne Hui-Fang Teng in:Nature Research journals • PubMed • Google ScholarSearch for Puay-Hoon Tan in:Nature Research journals • PubMed • Google ScholarSearch for Sing-Joo Chia in:Nature Research journals

Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1

The pancreatic and duodenal homeobox factor-1 (Pdx1) is essential for pancreatic development and insulin gene transcription, whereas c-Myc has a deleterious effect on islet function. However, the relationship between c-Myc and Pdx1 is poorly concerned. Here we demonstrated that Pdx1 could suppress c-Myc promoter activity, which relied on T cell factor (Tcf) binding elements...

Cloning of the Bacillus thuringiensis serovar sotto chitinase (Schi) gene and characterization of its protein

-Chao FangI; Ping-Zhong CaiII; Wen-Zhao YanII; Jie WuII; Hui-Fang GuoI IJiangsu Academy of Agricultural Sciences, Institute of Plant Protection, Nanjing, Jiangsu Province, China IISichuan Academy of

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells

Mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Uncoupling proteins (UCPs) delink ATP production from biofuel oxidation in mitochondria to reduce oxidative stress. UCP2 is expressed in brain, and has neuroprotective effects under various toxic insults. We observed induction of UCP2 expression by leptin...

Natural Selection and Adaptive Evolution of Leptin in the Ochotona Family Driven by the Cold Environmental Stress

BackgroundEnvironmental stress can accelerate the evolutionary rate of specific stress-response proteins and create new functions specialized for different environments, enhancing an organism's fitness to stressful environments. Pikas (order Lagomorpha), endemic, non-hibernating mammals in the modern Holarctic Region, live in cold regions at either high altitudes or high...

Brugia malayi Asparaginyl–Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes and Activates G-Protein–Coupled Receptors CXCR1 and CXCR2

BackgroundLymphatic filariasis is a chronic human parasitic disease in which the parasites repeatedly provoke acute and chronic inflammatory reactions in the host bloodstream and lymphatics. Excretory-secretory products derived from filariae are believed to play an important role in the development of associated immunologic conditions; however, the specific mechanisms involved in...

Prognostic Impact of Vascular Endothelial Growth Factor-A and E-Cadherin Expression in Completely Resected Pathologic Stage I Non-Small Cell Lung Cancer

The purpose of this study was to evaluate the value of vascular endothelial growth factor-A and E-cadherin expression as well as other confirmed prognostic factors in predicting the clinical outcome after definitive surgery of pathologic stage I non-small cell lung cancer.

Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent

Aim:To seek a novel and potent antitussive drug based on Shedan—Chuanbei powder, a complex of traditional Chinese medicine preparation for cough therapy.Methods:Verticinone—cholic acid (Ver—CA) salt, a novel, salifying derivative of verticinone and cholic acid, both of which are the major bioactive components in Shedan—Chuanbei powder, was synthesized. We then evaluated the...

Quantitative determination of acetylshikonin in macaque monkey blood by LC-ESI-MS/MS after precolumn derivatization with 2-mercaptoethanol and its application in pharmacokinetic study

-xiao SUN, Zhi-yun MENG, and Gui-fang DOU designed research; Dong-xiao SUN and Hui-fang TIAN performed research; Alicia DU, Zhuo-na WU contributed new analytical tools and reagents; Dong-xiao SUN, Zhiyun

Dietary intake and risk of rheumatoid arthritis—a cross section multicenter study

Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be an established risk factor for RA. Data regarding the impact of diet on risk of RA development is limited. This study assessed the impact of dietary patterns on RA susceptibility in Chinese populations. This was a large scale...

Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy

Introduction Triple negative breast cancer is associated with poorer prognosis and unresponsiveness to endocrine and anti-HER2 directed agents. Despite emerging data supporting the use of polyADP-ribose polymerase (PARP) inhibitors, complete and durable responses are rare and exploration of additional targeted therapies is needed. Epidermal growth factor receptor (EGFR) is...

Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat

Background/Aims Macrophages are known to play an important role in hepatocyte mediated liver regeneration by secreting inflammatory mediators. However, there is little information available on the role of resident macrophages in oval cell mediated liver regeneration. In the present study we aimed to investigate the role of macrophages in oval cell expansion induced by 2...

Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP+), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p<0.01), with 20% greater proton...

Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension

Institute Inc., Cary, NC, USA) under the responsibility of Hui Fang (Novartis Pharmaceuticals). Results Patient characteristics One thousand and thirty eight patients entered the single-blind placebo run-in ... Fang,^ Andrew Satlin^ Abstract Objective. To assess the antihypertensive efficacy and safety of the combination of the direct renin inhibitor aliskiren and ramipril in patients with diabetes and

9p21 Polymorphisms increase the risk of peripheral artery disease in the Han Chinese population

Objective A case–control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.

Genome-wide association study of Parkinson’s disease in East Asians

Zhong Pei 9 22 Rong Peng 6 22 Hui-Fang Shang 6 22 Kyuyoung Song 7 22 Ai Huey Tan 13 22 Yih-Ru Wu 14 22 Tin Aung 4 5 22 Ching-Yu Cheng 1 4 5 22 Fook Tim Chew 3 22 Soo-Hong Chew 0 22 Siow-Ann Chong 21 22

Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E

Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling technique. After screening and recombination with the prokaryotic non-fusion expression vector pBV220, two lysis plasmids were selected. Among which, a novel mutant E gene...

Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor

designed research; Hui WANG and Chang CHEN performed research; Hui-fang PI, Han-li RUAN, Peng ZHANG and Ji-zhou WU contributed analytical tools and analytical support; Jiu-liang ZHANG wrote the paper ... Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, ChinaJiu-liang Zhang, Hui Wang, Chang Chen, Hui-fang