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Small-Molecule Targets in Tumor Immunotherapy

Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies...

Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces

in enzyme activity. Author contribution Jian-feng XING and Ya-lin DONG designed the study, performed the research and wrote the paper. Hai-sheng YOU, Jun LU, Si-ying CHEN, Hui-fang ZHU, Qian DONG ... , the First Affiliated Hospital, Medical College, Xi-an Jiaotong University, Xi-an 710061, ChinaHai-sheng You, Ya-lin Dong, Jun Lu, Si-ying Chen, Hui-fang Zhu, Qian Dong, Mao-yi Wang & Wei-hua Dong