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Combined surgical-orthodontic treatment of patients with cleidocranial dysplasia: case report and review of the literature

To study the present treatment situation and investigate a better orthodontic approach for patients with cleidocranial dysplasia (CCD) through systematically reviewing the published cases and to conclude the surgical-orthodontic treatment experience of cleidocranial dysplasia. A comprehensive search for studies published through to April 10, 2018 was conducted using the Pubmed...

Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells

Abstract Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce anti-inflammatory, anti-oxidant, anti-tumor, and dopaminergic neurons protecting effects. This study aimed to determine...

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

Zhang Yongguo Dai 0 1 Roberto Mattioli 0 , Changyuan Wang , Yue Jin , Qining Yang , Qiang Meng, Qi Liu , Lifei Cai , Zhihao Liu , Kexin Liu, and Huijun Sun 1 Department of Clinical Pharmacology, College ... deviation ANOVA: Analysis of variance SNK: Student-Newman-Keuls HFD: High-fat diet. Conflicts of Interest The authors declare that they have no conflicts of interest. Authors? Contributions Huijun Sun

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

Zhang Yongguo Dai 0 1 Roberto Mattioli 0 , Changyuan Wang , Yue Jin , Qining Yang , Qiang Meng, Qi Liu , Lifei Cai , Zhihao Liu , Kexin Liu, and Huijun Sun 1 Department of Clinical Pharmacology, College ... deviation ANOVA: Analysis of variance SNK: Student-Newman-Keuls HFD: High-fat diet. Conflicts of Interest The authors declare that they have no conflicts of interest. Authors? Contributions Huijun Sun

Modeling and Simulating Passenger Behavior for a Station Closure in a Rail Transit Network

A station closure is an abnormal operational situation in which the entrances or exits of a rail transit station have to be closed for some time due to an unexpected incident. A novel approach is developed to estimate the impacts of the alternative station closure scenarios on both passenger behavioral choices at the individual level and passenger demand at the disaggregate level...

Analysis of Road Network Pattern Considering Population Distribution and Central Business District

This paper proposes a road network growing model with the consideration of population distribution and central business district (CBD) attraction. In the model, the relative neighborhood graph (RNG) is introduced as the connection mechanism to capture the characteristics of road network topology. The simulation experiment is set up to illustrate the effects of population...

Analysis of Time of Day Fare Discounts on Urban Mass Transit Travel Behavior, Crowding, and Waiting Time

Copyright © 2014 Xiao Guo and Huijun Sun. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Topological Effects and Performance Optimization in Transportation Continuous Network Design

Because of the limitation of budget, in the planning of road works, increased efforts should be made on links that are more critical to the whole traffic system. Therefore, it would be helpful to model and evaluate the vulnerability and reliability of the transportation network when the network design is processing. This paper proposes a bilevel transportation network design...

Topological Effects and Performance Optimization in Transportation Continuous Network Design

Because of the limitation of budget, in the planning of road works, increased efforts should be made on links that are more critical to the whole traffic system. Therefore, it would be helpful to model and evaluate the vulnerability and reliability of the transportation network when the network design is processing. This paper proposes a bilevel transportation network design...

Topological Effects and Performance Optimization in Transportation Continuous Network Design

Because of the limitation of budget, in the planning of road works, increased efforts should be made on links that are more critical to the whole traffic system. Therefore, it would be helpful to model and evaluate the vulnerability and reliability of the transportation network when the network design is processing. This paper proposes a bilevel transportation network design...

Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines

Background Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their effect on osteoporosis treatment are poorly understood...

Potent effects of dioscin against obesity in mice

Lvshunnan Road, Dalian 116044, ChinaMin Liu, Lina Xu, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Yanyan Zhao, Huijun Sun, Jihong Yao, Yuan Lin, Kexin Liu & Jinyong PengResearch Institute of Integrated ... ScholarSearch for Huijun Sun in:Nature Research journals • PubMed • Google ScholarSearch for Jihong Yao in:Nature Research journals • PubMed • Google ScholarSearch for Yuan Lin in:Nature Research journals

Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis

Lipoprotein lipase (LPL) is a key enzyme in the hydrolysis of triglyceride-rich lipoproteins. Previous studies using transgenic mice and rabbits have demonstrated that high level of LPL activity in adipose and skeletal muscle protects against diet-induced hypercholesterolemia and subsequently prevents aortic atherosclerosis. However, it is unknown, per se, whether increased LPL...