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72 papers found.
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Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes

Sodium/glucose cotransporter 2 (SGLT2) inhibitor improves systemic glucose metabolism. To clarify the effect of dapagliflozin, we performed gene expression microarray and metabolomic analyses of murine adipose tissue. Three groups of mice were used; non-diabetic control KK mice (KK), diabetic KKAy mice (KKAy), and KKAy mice treated with dapagliflozin (KKAy + Dapa). Plasma glucose...

Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis

Daiichi Sankyo Co., Ltd., Ferring Pharma, and Tiho Pharma K.K.; travel fees from Takeda Pharmaceutical Co.; and manuscript fees from Kowa Co., Ltd. Iichiro Shimomura has received lecture fees from Astellas

Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells

The significance of glucagon in the pathophysiology of diabetes mellitus is widely recognized, but the mechanisms underlying dysregulated glucagon secretion are still unclear. Here, we explored the molecular mechanisms of glucagon dysregulation, using an in vitro model. Hamster-derived glucagon-secreting InR1G cells were exposed to high glucose (25 mM) levels for 12 h before...

Rationale and Design for the J-DISCOVER Study: DISCOVERing the Treatment Reality of Type 2 Diabetes in a Real-World Setting in Japan—A Protocol

, Novo Nordisk Pharma Ltd., Ono Pharmaceutical Co., Sanwa Kagaku Kenkyusho, and Takeda Pharmaceutical Co. Ltd. Iichiro Shimomura has received honoraria from Astellas Pharma Inc., AstraZeneca, Boehringer

Evaluation of the Effect of Alogliptin on Tissue Characteristics of the Carotid Wall: Subanalysis of the SPEAD-A Trial

Corp. Eli Lilly, Mitsubishi Tanabe Pharma, Daiichi Sankyo Inc., Takeda Pharmaceutical Co., MSD, Shionogi, Pharma, Dainippon Sumitomo Pharma, Kissei Pharma, and Astrazeneca K.K. Iichiro Shimomura received

The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

Thickness Evaluation Tomoya Mita; pj.ca.odnetnuj@m-mot,1 Naoto Katakami,2,3 Toshihiko Shiraiwa,4 Hidenori Yoshii,5 Masahiko Gosho,6 Iichiro Shimomura,2 and Hirotaka Watada1 1Department of Metabolism and ... Pharmaceutical Co. Masahiko Gosho received lecture fees from Novartis and Tiho Pharma K.K., received travel fees from Takeda Pharmaceutical Co., and received manuscript fee from Kowa Co., Ltd. Iichiro Shimomura

The Effect of Sitagliptin on the Regression of Carotid Intima-Media Thickening in Patients with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation

Thickness Evaluation Tomoya Mita; pj.ca.odnetnuj@m-mot,1 Naoto Katakami,2,3 Toshihiko Shiraiwa,4 Hidenori Yoshii,5 Masahiko Gosho,6 Iichiro Shimomura,2 and Hirotaka Watada1 1Department of Metabolism and ... Pharmaceutical Co. Masahiko Gosho received lecture fees from Novartis and Tiho Pharma K.K., received travel fees from Takeda Pharmaceutical Co., and received manuscript fee from Kowa Co., Ltd. Iichiro Shimomura

The Influence of Sitagliptin on Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Prespecified Sub-Analysis

& Co., Kowa Pharmaceutical Co. Ltd., Boehringer Ingelheim, Novo Nordisk Pharma Ltd., Sumitomo Dainippon Pharma, and Kyowa Hakko Kirin Co. Ltd, unrelated to the submitted work. Iichiro Shimomura received

Examination of a Viral Infection Mimetic Model in Human iPS Cell-Derived Insulin-Producing Cells and the Anti-Apoptotic Effect of GLP-1 Analogue

Aims Viral infection is associated with pancreatic beta cell destruction in fulminant type 1 diabetes mellitus. The aim of this study was to investigate the acceleration and protective mechanisms of beta cell destruction by establishing a model of viral infection in pancreatic beta cells. Methods Polyinosinic:polycytidylic acid was transfected into MIN6 cells and insulin...

Risk categorization for calculating net reclassification improvement

Mitsuyoshi Takahara Naoto Katakami Hideaki Kaneto Iichiro Shimomura - We read with great interest a recent report by Muhlenbruch and colleagues [1], clearly demonstrating the dependency of the net

Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects

Background Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the...

Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Background Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are...

Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study

The UTOPIA trial was designed by the principal investigators (Iichiro Shimomura, Osaka University Graduate School of Medicine, Osaka, Japan and Hirotaka Watada, Juntendo University School of Medicine ... Japan Inc., Bristol-Myers Squibb K.K., Benefit one Health care Inc., and Mochida Pharmaceutical Co., Ltd.; and funds of endowed chair from MSD K.K. and Takeda Pharmaceutical Company Limited. Iichiro

Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients

Abstract Background Brachial-ankle pulse wave velocity (baPWV) is a method to estimate arterial stiffness, which reflects the stiffness of both the aorta and peripheral artery; it would be applicable to general practice, since its measurementis automated. The aim of this study was to evaluate whether baPWV can be predictors of future cardiovascular events (CVE) in diabetic...

Low serum eicosapentaenoic acid / arachidonic acid ratio in male subjects with visceral obesity

Shimomura 1 0 Kishida Clinic , 5-6-3, Honmachi, Toyonaka, Osaka 560-0021 , Japan 1 Department of Metabolic Medicine, Graduate School of Medicine, Osaka University , Suita, Osaka 565-0871 , Japan Background

Chronological Analysis With Fluorescent Timer Reveals Unique Features of Newly Generated β-Cells

Although numerous studies have uncovered the molecular mechanisms regulating pancreas development, it remains to be clarified how β-cells arise from progenitors and how recently specified β-cells are different from preexisting β-cells. To address these questions, we developed a mouse model in which the insulin 1 promoter drives DsRed-E5 Timer fluorescence that shifts its spectrum...

Clinical significance of visceral fat reduction through health education in preventing atherosclerotic cardiovascular disease - Lesson from the Amagasaki Visceral Fat Study: A Japanese perspective

professor in the Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University. Dr Funahashis research interests the metabolic syndrome and atherosclerosis. Iichiro Shimomura, MD

Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice

Aims/hypothesis Lineage conversion of non-beta cells into insulin-producing cells has been proposed as a therapy for the cure of diabetes. Glucagon-like peptide-1 (GLP-1) and its derivatives can induce beta cell neogenesis in vitro and beta cell mass expansion in vivo, but GLP-1 signalling has not been shown to regulate cell fate decisions in vivo. We therefore tested the impact...

Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report

Kobayashi Tohru Nakagawa Tohru Funahashi 1 Iichiro Shimomura 1 0 Kishida Clinic , Osaka 560-0021 , Japan 1 Department of Metabolic Medicine, Graduate School of Medicine, Osaka University , Osaka 565-0871

Sleep-wake cycle irregularities in type 2 diabetics

BackgroundThe incidence of type 2 diabetes mellitus (T2DM) has been increasing in recent years. Sleep loss and circadian rhythm abnormalities are thought to be one of the underlying causes of adverse metabolic health. However, little is known about sleep-wake cycle irregularities in T2DM. The present study compared the bedtime, waking time, and estimated sleep duration between...