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Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes

the manuscript; BIF designed the study, contributed to data analyses, interpretation, and drafted the manuscript. Author Contributions Conceptualization: Donald W. Bowden, J. Jeffrey Carr, Barry I ... . Freedman. Data curation: Gary C. Chan, Carl D. Langefeld, Jianzhao Xu, S. Carrie Smith, J. Jeffrey Carr, Leon Lenchik, Barry I. Freedman. Formal analysis: Jasmin Divers, Gregory B. Russell, Lynne E

Serum Urate and Incident Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Objective There is controversy about whether serum urate (sUA) predicts future cardiovascular disease (CVD) independently of classical risk factors, and the age at which any prediction starts. We studied the sUA-CVD association among generally healthy adults. Methods CARDIA recruited 5115 black and white individuals aged 18–30 years in 1985–1986 (year-0). Fatal and nonfatal CVD...

Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study

Vascular calcified plaque, a measure of subclinical cardiovascular disease (CVD), is unlikely to be limited to a single vascular bed in patients with multiple risk factors. Consideration of vascular calcified plaque as a global phenomenon may allow for a more accurate assessment of the CVD burden. The aim of this study was to examine the utility of a combined vascular calcified...

Hemoglobin A1c and the Progression of Coronary Artery Calcification Among Adults Without Diabetes

OBJECTIVE Higher levels of hemoglobin A1c (HbA1c) are associated with increased cardiovascular disease risk among individuals without diabetes and may also be positively associated with coronary artery calcification (CAC). This study investigated the association of HbA1c with CAC progression in the Coronary Artery Risk Development in Young Adults study.

Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

Background Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM). Methods This study examined the association of HP genotypes with subclinical CVD, T2DM risk, and...

Ten-Year Trends in Coronary Calcification in Individuals without Clinical Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis

Background Coronary heart disease (CHD) incidence has declined significantly in the US, as have levels of major coronary risk factors, including LDL-cholesterol, hypertension and smoking, but whether trends in subclinical atherosclerosis mirror these trends is not known. Methods and Findings To describe recent secular trends in subclinical atherosclerosis as measured by serial...

Coronary Calcium Score Predicts Cardiovascular Mortality in Diabetes: Diabetes Heart Study

SUBHASHISH AGARWAL MS AMANDA J. COX PHD DAVID M. HERRINGTON MHS NEAL W. JORGENSEN MS JIANZHAO XU BS BARRY I. FREEDMAN J. JEFFREY CARR MSCE DONALD W. BOWDEN PHD C a r d i o v a s c u l a r

Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study

Background Patients with type 2 diabetes (T2D) are at elevated risk for cardiovascular disease (CVD) events and mortality. Recent studies have assessed the impact of genetic variants affecting high-density lipoprotein cholesterol (HDL) concentrations on CVD risk in the general population. This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for...

Coronary Calcium Score and Prediction of All-Cause Mortality in Diabetes: The Diabetes Heart Study

SUBHASHISH AGARWAL TIMOTHY MORGAN PHD DAVID M. HERRINGTON MHS JIANZHAO XU BS AMANDA J. COX PHD BARRY I. FREEDMAN J. JEFFREY CARR MSCE DONALD W. BOWDEN PHD C a r d i o v a s c u l a r a n d OBJECTIVE

Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

Background Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D). Methods Serum MCP-1 concentration, urine...

Pericardial Fat and Myocardial Perfusion in Asymptomatic Adults from the Multi-Ethnic Study of Atherosclerosis

Background Pericardial fat has adverse effects on the surrounding vasculature. Previous studies suggest that pericardial fat may contribute to myocardial ischemia in symptomatic individuals. However, it is unknown if pericardial fat has similar effects in asymptomatic individuals. Methods We determined the association between pericardial fat and myocardial blood flow (MBF) in 214...

Ethnic Differences in the Relationship Between Albuminuria and Calcified Atherosclerotic Plaque: The African American-Diabetes Heart Study

JASMIN DIVERS PHD LYNNE E. WAGENKNECHT DRPH DONALD W. BOWDEN PHD J. JEFFREY CARR R. CARESSE HIGHTOWER BS JIANZHAO XU BS CARL D. LANGEFELD PHD BARRY I. FREEDMAN OBJECTIVE - Despite higher rates of

Association of Coronary Artery and Aortic Calcium With Lumbar Bone Density: The MESA Abdominal Aortic Calcium Study

The MESA Abdominal Aortic Calcium Study Joseph A. Hyder ) Matthew A. Allison Nathan Wong Agnes Papa Thomas F. Lang Claude Sirlin Susan M. Gapstur Pamela Ouyang J. Jeffrey Carr Michael H. Criqui

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

 Carl D. Langefeld,3 Donald W. Bowden,1,2,4 Thomas C. Register,5 Yongmei Liu,3 Barry I. Freedman,4 J. Jeffrey Carr,3,6 Catherine C. Hedrick,7 and Stephen S. Rich3,7,8 1Department of Biochemistry, Wake

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

 Carl D. Langefeld,3 Donald W. Bowden,1,2,4 Thomas C. Register,5 Yongmei Liu,3 Barry I. Freedman,4 J. Jeffrey Carr,3,6 Catherine C. Hedrick,7 and Stephen S. Rich3,7,8 1Department of Biochemistry, Wake

Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study

Background Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for...

Relation of Retinopathy to Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis

Microvascular disease, reflected by retinal vascular changes, has been shown to predict clinical coronary heart disease. Whether retinal vascular changes are associated with subclinical coronary artery disease is unclear and was examined in this study. The authors conducted a multiethnic, population-based study of 6,147 persons aged 45–84 years, sampled from six US communities in...

Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

D. Taylor Matthew Allison Matthew Budoff The CARDIoGRAM Consortium Jerome I. Rotter J. Jeffrey Carr Udo Hoffmann Jingzhong Ding L. Adrienne Cupples Yongmei Liu Michael Snyder, Stanford University