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13 papers found.
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Lower serotonin transporter binding in patients with cervical dystonia is associated with psychiatric symptoms

Background Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonergic and dopaminergic systems are closely related. As serotonin is involved in the pathophysiology of psychiatric symptoms and jerks, we expected an altered...

The relationship between the dopaminergic system and depressive symptoms in cervical dystonia

analysis, writing of the first draft. M.A.J. Tijssen and J. Booij: conception of the research project, review and critique of the statistical analysis and manuscript. Y.E.M. Dreissen: execution of the

[123]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies

the reassessment of the [123I]FP-CIT SPECT scans Compliance with ethical standards Conflicts of interest J. Booij is a consultant at GE Healthcare, and received research grants (paid to the institution ... ; 85 ( 2 ): 159 - 64 . doi: 10 .1136/ jnnp-2012-304811. 17. Darcourt J , Booij J , Tatsch K , Varrone A , Vander Borght T , Kapucu OL , et al. EANM procedure guidelines for brain neurotransmission SPECT

Modelling the Influence of Groundwater Abstractions on the Water Level of Lake Naivasha, Kenya Under Data-Scarce Conditions

J. Booij 0 1 0 Water Resources Management Group, Wageningen University , P.O. Box 47, 6700 AA Wageningen , The Netherlands 1 Twente Water Centre, University of Twente , P.O. Box 217, 7500 AE Enschede

No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder

Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified...

Deterministic-statistical Model Coupling in a DSS for River-Basin Management

Jean-Luc de Kok Martijn J. Booij 0 ) Department of Water Engineering and Management, University of Twente , P.O. Box 217, 7500 AE Enschede, The Netherlands This paper presents a method for

Identification and Quantification of Uncertainties in a Hydrodynamic River Model Using Expert Opinions

Hydrodynamic river models are applied to design and evaluate measures for purposes such as safety against flooding. The modelling of river processes involves numerous uncertainties, resulting in uncertain model outcomes. Knowledge of the type and magnitude of uncertainties is crucial for a meaningful interpretation of the model results and the usefulness of results in decision...

Catchment Variability and Parameter Estimation in Multi-Objective Regionalisation of a Rainfall–Runoff Model

This study attempts to examine if catchment variability favours regionalisation by principles of catchment similarity. Our work combines calibration of a simple conceptual model for multiple objectives and multi-regression analyses to establish a regional model between model sensitive parameters and physical catchment characteristics (PCCs). The objective is to test robustness of...

Reduced striatal D2 receptor binding in myoclonus–dystonia

Purpose To study striatal dopamine D2 receptor availability in DYT11 mutation carriers of the autosomal dominantly inherited disorder myoclonus–dystonia (M–D). Methods Fifteen DYT11 mutation carriers (11 clinically affected) and 15 age- and sex-matched controls were studied using 123I-IBZM SPECT. Specific striatal binding ratios were calculated using standard templates for...

Loss of thalamic serotonin transporters in early drug-naïve Parkinson’s disease patients is associated with tremor: an [123I]β-CIT SPECT study

In vitro studies revealed serotonin transporter (5-HTT) decline in Parkinson’s disease (PD). Yet, few studies investigated thalamic 5-HTT in vivo and its effect on PD heterogeneity. We analyzed thalamic [123I]β-CIT binding (mainly reflecting 5-HTT binding) in 32 drug-naïve PD patients and 13 controls with SPECT. Twenty-six patients were examined twice (17 months apart). Based on...

Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT

A pivotal question in neuropharmacology is how the function of neurotransmitter systems relates to psychiatric diseases. In experimental neuropharmacology, we have dreamt about a looking glass that would allow us to see neurotransmitter systems in action, and about animals that would faithfully serve us as models for human psychiatric disease. Analysis of animal models has been...