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Prevalence and cardiac phenotype of patients with a phospholamban mutation

Pathogenic mutations in the phospholamban (PLN) gene may give rise to inherited cardiomyopathies due to its role in calcium homeostasis. Several PLN mutations have been identified, with the R14del mutation being the most prevalent cardiomyopathy-related mutation in the Netherlands. It is present in patients diagnosed with arrhythmogenic cardiomyopathy as well as dilated...

The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update

BackgroundClinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions.AimTo create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research.MethodsThis is a multicentre, longitudinal...

A decade of atrial fibrillation ablation

Background Over the past decade, radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has evolved into a frequently performed procedure. The aim of this study was to monitor changes in patient characteristics, procedural characteristics, outcomes and complications over the past 10 years. Methods All consecutive patients who underwent primary RFCA treatment of AF in...

Left cardiac sympathetic denervation for the treatment of inherited arrhythmia syndromes: salvation for the desperate?

M. Voskuil J. F. van der Heijden - In the large majority of patients, ventricular arrhythmias are caused by myocardial ischaemia and/or infarction because of underlying coronary artery disease

Clinical characterisation and risk stratification of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy ≥50 years of age

. van der Heijden, M. J. Cramer, R.N. Hauer and A.S.J.M. te Riele declare that they have no competing interests. Open Access This article is distributed under the terms of the Creative Commons ... Heart Foundation (2015T058 to A.S.J.M. te Riele) and by the Interuniversity Cardiology Institute of the Netherlands (ICIN), project 06901. Conflict of interest M.J. van der Pols, T.P. Mast, P. Loh, J. F

The phospholamban p.Arg14del founder mutation in Dutch patients with arrhythmogenic cardiomyopathy

J. F. van der Heijden 0 R. J. Hassink 0 0 J. F. van der Heijden ( - Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is considered a hereditary cardiac disease, characterised by

Arrhythmogenic cardiomyopathy: diagnosis, genetic background, and risk management

Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is a hereditary disease characterised by ventricular arrhythmias, right ventricular and/or left ventricular dysfunction, and fibrofatty replacement of cardiomyocytes. Patients with AC typically present between the second and the fourth decade of life with...