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Incretin responses to oral glucose and mixed meal tests and changes in fasting glucose levels during 7 years of follow-up: The Hoorn Meal Study

. Rutters, M. Alssema. Writing ± review & editing: S. P. Rauh, G. Nijpels, J. J. Holst, J. W. Beulens, J. M. Dekker. 11 / 13 12 / 13 1. Boyle PJ , Freeman JS . Application of incretin mimetics and

The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss

journals • PubMed • Google ScholarSearch for A Asmar in:Nature Research journals • PubMed • Google ScholarSearch for P Nordby in:Nature Research journals • PubMed • Google ScholarSearch for J J Holst

Incretin hormones and the satiation signal

Recent research has indicated that appetite-regulating hormones from the gut may have therapeutic potential. The incretin hormone, glucagon-like peptide-1 (GLP-1), appears to be involved in both peripheral and central pathways mediating satiation. Several studies have also indicated that GLP-1 levels and responses to meals may be altered in obese subjects. Clinical trial results...

Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?

The aim of this study was to investigate subcutaneous adipose tissue lymphatic drainage (ATLD) of macromolecules in lean and obese subjects and, furthermore, to evaluate whether ATLD may change in parallel with adipose tissue blood flow. Lean and obese male subjects were studied before and after an oral glucose load. Adipose-tissue blood flow was measured in the anterior...

Adult glucose metabolism in extremely birthweight-discordant monozygotic twins

Aims/hypothesis Low birthweight (BW) is associated with increased risk of type 2 diabetes. We compared glucose metabolism in adult BW-discordant monozygotic (MZ) twins, thereby controlling for genetic factors and rearing environment. Methods Among 77,885 twins in the Danish Twin Registry, 155 of the most BW-discordant MZ twin pairs (median BW difference 0.5 kg) were assessed...

Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

Background:Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors. Thus, during weight loss maintenance, GLP-1 receptor agonist (GLP-1RA) administration may inhibit weight loss-induced increases in soluble leptin receptors thereby preserving free leptin levels and preventing weight regain.Methods:In a...

Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

K. R. Hjllund C. F. Deacon J. J. Holst Abbreviations DPP- Dipeptidyl peptidase GLP- Glucagon-like peptide- NC Neuromedin C 0 ) Department of Biomedical Sciences, University of Copenhagen, The Panum

Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies

Aims/hypothesisWe carried out a systematic review of clinical studies investigating glucagon-like peptide-1 (GLP-1) secretion in patients with type 2 diabetes and non-diabetic controls and performed meta-analyses of plasma total GLP-1 concentrations during an OGTT and/or meal test.MethodsRandom effects models for the primary meta-analysis and random effects meta-regression...

Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005

J. J. Holst The incretin hormones are intestinal polypeptides that enhance postprandial insulin secretion. Gastric inhibitory polypeptide (GIP) was initially thought to regulate gastric acid

Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

, Hvidovre, Denmark 3 J. J. Holst Department of Biomedical Sciences, The Panum Institute, University of Copenhagen , Copenhagen, Denmark 4 A. Vlund Department of Endocrinology, Bispebjerg University Hospital

Satiety scores and satiety hormone response after sucrose-sweetened soft drink compared with isocaloric semi-skimmed milk and with non-caloric soft drink: a controlled trial

Background/Objectives:Observational studies indicate that sugar-sweetened soft drinks (SSSD) may promote obesity, among other factors, owing to low-satiating effects. The effect of energy in drinks on appetite is still unclear. We examined the effect of two isocaloric, but macronutrient, different beverages (SSSD versus semi-skimmed milk) and two non-energy-containing beverages...

Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

Aims/hypothesisHeritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1...

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Background/Objectives:Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients.Subjects/Methods:Twelve SBS patients in this randomised cross-over study received 4 weeks...

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

The incretin hormones gastric inhibitory polypeptide and especially glucagon-like peptide (GLP) have an important physiological function in augmenting postprandial insulin secretion. Since GLP-1 may play a role in the pathophysiology and treatment of type 2 diabetes, assessment of meal-related GLP-1 secretory responses in type 2 diabetic patients vs healthy individuals is of...

Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes?

Prior to the development of type 2 diabetes, glucose levels increase into the prediabetic states of isolated impaired fasting glycaemia (i-IFG), isolated impaired glucose tolerance (i-IGT), or combined IFG/IGT. A better understanding of the aetiology and pathophysiology of the prediabetic states might give a basis for the development of individualised prevention and treatment...

Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass

C. Dirksen N. B. Jrgensen K. N. Bojsen-Mller S. H. Jacobsen D. L. Hansen D. Worm J. J. Holst S. Madsbad Roux-en-Y gastric bypass (RYGB) greatly improves glycaemic control in morbidly obese patients

Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease

. Zethelius Department of Public Health and Caring Sciences/Geriatrics, Uppsala University , Uppsala, Sweden 2 J. J. Holst Department of Biomedical Sciences, The Panum Institute, University of Copenhagen

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

obtained by FACS do not represent pure alpha cell populations, but are contaminated with a certain number of other islet cells. Immunohistochemical studies by our group (C. Orskov, J. de Heer and J. J. Holst

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

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Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

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