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34 papers found.
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The cultivation and physiological ecology of members of salt marsh epiphytic communities

1. Members of the epiphytic communities ofZostera, Enteromorpha, Ulva and other marine macrophytes occurring in North Sea Harbor, Southampton, New York are being isolated in gnotobiotic culture as part of a broader program of studies on the trophic dynamics and mineral cycling of the community. 2. Aseptic samples are taken in the field, by means of sterile forceps, and inoculated...

Effects of acanthoic acid on TNF-α gene expression and haptoglobin synthesis

Tumour necrosis factor-α (TNF-α) is a major proinflammatory cytokine inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoim mune diseases, and inflammation. Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11), 15-dien19-oic acid, a pimaradiene diterpene isolated from Acanth opanax koreanum, inhibited TNF...

Anti-inflammatory effects of Stephania tetrandra S. Moore on interleukin-6 production and experimental inflammatory disease models

, J-J. Lee, I. ChoicA and K-H. Pyun ingested by alveolar monocytes/macrophages, which then release oxygen free radicals and lysosomal enzymes which damage lung tissue. 5 They also release pro

Predicting educational achievement from DNA

for P S Dale in:Nature Research journals • PubMed • Google ScholarSearch for J J Lee in:Nature Research journals • PubMed • Google ScholarSearch for R Plomin in:Nature Research journals • PubMed

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

Cellular senescence is an important mechanism for preventing tumor progression. The elevated expression of Bcl-2-interacting cell death suppressor (BIS), an anti-apoptotic and anti-stress protein, often correlates with poor prognosis in several cancers including glioblastoma; however, the role of BIS in the regulation of senescence has not been well defined. Here, we describe for...

Resistance of CD-1 and ogg1 DNA Repair–Deficient Mice to Thalidomide and Hydrolysis Product Embryopathies in Embryo Culture

Crystal J. J. Lee Luisa L. Gonxcalves 1 Peter G. Wells 0 0 Department of Pharmacology and Toxicology, University of Toronto , Toronto, Ontario , Canada M5S 3M2 1 Present address: Instituto de

Phase II trial of everolimus and erlotinib in patients with platinum-resistant recurrent and/or metastatic head and neck squamous cell carcinoma

Background Enhanced phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key adaptive changes accounting for epidermal growth factor receptor (EGFR) inhibitor-resistant growth in head and neck squamous cell carcinoma (HNSCC). We designed a phase II clinical trial of EGFR tyrosine kinase inhibitor (TKI), erlotinib, in association with the...

Fluorothalidomide: A Characterization of Maternal and Developmental Toxicity in Rabbits and Mice

The expanding therapeutic uses of thalidomide (TD) are limited by its teratogenic side effects. Although the therapeutic and teratogenic effects may be stereoselectively separable, rapid in vivo racemization of the TD isomers confounds the corroboration of this distinction. Herein we evaluated the potential of fluorothalidomide (FTD), the closest structural analog of TD with...

Phase II study of dovitinib in patients with metastatic and/or unresectable gastrointestinal stromal tumours after failure of imatinib and sunitinib

Background:This prospective, phase II trial evaluated the efficacy and safety of dovitinib in patients with metastatic and/or unresectable gastrointestinal stromal tumours (GISTs) after failure of at least imatinib and sunitinib.Methods:Patients received oral dovitinib, 500 mg once daily, for 5 consecutive days, followed by a 2-day rest, every 28 days. The primary endpoint was...

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) has frequently been observed in human gliomas, conferring AKT activation and resistance to ionizing radiation (IR) and drug treatments. Recent reports have shown that PTEN loss or AKT activation induces premature senescence, but many details regarding this effect remain obscure. In this study, we tested whether...

Origin of the dust emission from Tycho's SNR

Aims. We investigate the spatial distribution of dust emission around Tycho's SNR to understand its origin. We distinguish the dust associated with the SNR from that of the surrounding ISM.Methods. We performed mid- to far-infrared imaging observations of the remnant at wavelengths of 9, 15, 18, 24, 65, 90, 140, and 160 μm using the Infrared Camera and the Far-Infrared Surveyor...

CR represents an early index of potential long survival in multiple myeloma

Delasalle, L Feng, S Thomas, S Giralt, M Qazilbash, B Handy, J J Lee & R Alexanian AuthorsSearch for M Wang in:Nature Research journals • PubMed • Google ScholarSearch for K Delasalle in:Nature Research ... Research journals • PubMed • Google ScholarSearch for M Qazilbash in:Nature Research journals • PubMed • Google ScholarSearch for B Handy in:Nature Research journals • PubMed • Google ScholarSearch for J J

Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications

Background Malignant pleural mesothelioma (MPM) is a lethal neoplasm exhibiting resistance to most treatment regimens and requires effective therapeutic options. Though an effective strategy in many cancer, targeted therapy is relatively unexplored in MPM because the therapeutically important oncogenic pathways and networks in MPM are largely unknown.

The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival

Background: The aim of this study is to investigate the prognostic role of phosphorylated AMP-activated protein kinase (pAMPK) in surgically resected non-small-cell lung cancer (NSCLC). Methods: Immunohistochemical staining of pAMPK was carried out on tissue microarrays containing 463 samples obtained from patients with NSCLC and correlated with clinicopathological...

Effect of missing killer-immunoglobulin-like receptor ligand in recipients undergoing HLA full matched, non-T-depleted sibling donor transplantation: a single institution experience of 151 Asian patients

the SingHealth Research Foundation SRF#113/05. Author information AffiliationsDepartment of Haematology, Singapore General Hospital, SingaporeY C Linn, K K Heng, J J Lee, Y Loh, W Hwang, Y T Goh & M ... Chong in:Nature Research journals • PubMed • Google ScholarSearch for K K Heng in:Nature Research journals • PubMed • Google ScholarSearch for J J Lee in:Nature Research journals • PubMed • Google

Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post auto-SCT and its correlation with survival outcome

We performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome. Following autologous transplant and engraftment, 30 patients (35.7%) had a transient secondary decline in their plt counts, which was not...