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State of the art in osteoporosis risk assessment and treatment

for osteoporosis actually do so. KeywordsOsteoporosis Epidemiology Risk FRAX Fracture Prevention  J. Liu and E. Curtis are joint first authors. Introduction Osteoporosis is defined by the World

Changes in subsidence-field surface movement in shallow-seam coal mining

Intensive mining of shallow coal seams tends to result in severe subsidence of the ground surface. Surface subsidence is a complex dynamic spatiotemporal process that constantly changes as mining advances. With Liangshuijing coal mine as a case study, 3DEC numerical software was used to simulate the development of the moving subsidence field from open-off cut to full subsidence...

A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations

In embryogenesis, mesenchymal condensation is a critical event during the formation of many organ systems, including cartilage and bone. During organ formation, mesenchymal cells aggregate and undergo compaction while activating developmental programmes. The final three-dimensional form of the organ, as well as cell fates, can be influenced by the size and shape of the forming...

Inferring statistical properties of 3D cell geometry from 2D slices

investigation and for helpful discussions. Author Contributions Conceptualization: Tristan A. Sharp, Andrea J. Liu. Data curation: Tristan A. Sharp. Formal analysis: Tristan A. Sharp, Matthias Merkel, M. Lisa ... Manning, Andrea J. Liu. Funding acquisition: M. Lisa Manning, Andrea J. Liu. Investigation: Tristan A. Sharp, Matthias Merkel, M. Lisa Manning, Andrea J. Liu. Methodology: Tristan A. Sharp, Matthias Merkel

Endoscopic Treatment for Gastroesophageal Reflux Disease: Should You Learn the Techniques?

Can J Gastroenterol Endoscopic treatment for gastroesophageal reflux disease: Should you learn the techniques? Julia J Liu FRCPC FACP FACG 0 Dr Julia J Liu 0 0 University of Alberta Hospital

Endoscopic Treatment for Gastroesophageal Reflux Disease: Should You Learn the Techniques?

Can J Gastroenterol Endoscopic treatment for gastroesophageal reflux disease: Should you learn the techniques? Julia J Liu FRCPC FACP FACG 0 Dr Julia J Liu 0 0 University of Alberta Hospital

Multi-scale modelling of granular materials: numerical framework and study on micro-structural features

A multi-scale model for the analysis of granular systems is proposed, which combines the principles of a coupled FEM–DEM approach with a novel servo-control methodology for the implementation of appropriate micro-scale boundary conditions. A mesh convergence study is performed, whereby the results of a quasi-static biaxial compression test are compared with those obtained by...

Endoscopic comparison of gastroduodenal injury with over-the-counter doses of new fast-dissolving ibuprofen and paracetamol formulations: a randomized, placebo-controlled, 4-way crossover clinical trial

Endoscopic comparison of gastroduodenal injury with over-the-counter doses of new fast-dissolving ibuprofen and paracetamol formulations: a randomized, placebo-controlled, 4-way crossover clinical trial Frank L Lanza,1 Agron Collaku,2 Dongzhou J Liu3 1Department of Gastroenterology, Houston Institute for Clinical Research, Houston, TX, USA; 2Biostatistics Department...

Robust Hydrophobic Surfaces from Suspension HVOF Thermal Sprayed Rare-Earth Oxide Ceramics Coatings

experiments, analysed data, and wrote the manuscript; H. Kazi, X. Zhang and J. Liu supported the experiments and assisted in data analysis. T. Hussain supervised the projects, interpreted data and reviewed the

The triphibious warfare against viruses

stages. Compliance and ethics     The author(s) declare that they have no conflict of interest. Biographical Sketch Dr. William J. Liu was born in Inner Mongolia, China, and graduated from the School of ... . , Qin , K. , Zhang , X.W. , Zhang , X.L. , Zhao , D. , Wang , G. , Feng , Y. , Ma , J., Liu , W. , Wang , J. , and Gao , G.F. ( 2005 ). Highly pathogenic H5N1 influenza virus infection in migratory birds

Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model

, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, ChinaL. Peng, Q. Li, H. Wang, J. Wu, C. Li, Y. Liu, J. Liu & Y. XiaCore Research Laboratory, The Second Affiliated ... Research journals • PubMed • Google Scholar Search for Y. Liu in:Nature Research journals • PubMed • Google Scholar Search for J. Liu in:Nature Research journals • PubMed • Google Scholar Search for L

Endoscopic pH Monitoring for Patients with Suspected or Refractory Gastroesophageal Reflux Disease

with suspected or refractory gastroesophageal reflux disease Brian G Turner John R Saltzman Ling Hua Rie Maurer MA Natan Feldman David L Carr-Locke Robert Burakoff Julia J Liu Ambulatory pH monitoring ... Correspondence: Dr Julia J Liu, Division of Gastroenterology, University of Alberta Hospital, 1-10 Zeidler Ledcor Centre, University of Alberta Campus, Edmonton, Alberta T6R 2C1. Telephone 780-492-6874, fax 780

Endoscopic pH Monitoring for Patients with Suspected or Refractory Gastroesophageal Reflux Disease

with suspected or refractory gastroesophageal reflux disease Brian G Turner John R Saltzman Ling Hua Rie Maurer MA Natan Feldman David L Carr-Locke Robert Burakoff Julia J Liu Ambulatory pH monitoring ... Correspondence: Dr Julia J Liu, Division of Gastroenterology, University of Alberta Hospital, 1-10 Zeidler Ledcor Centre, University of Alberta Campus, Edmonton, Alberta T6R 2C1. Telephone 780-492-6874, fax 780

Formulation and numerical implementation of micro-scale boundary conditions for particle aggregates

Novel numerical algorithms are presented for the implementation of micro-scale boundary conditions of particle aggregates modelled with the discrete element method. The algorithms are based on a servo-control methodology, using a feedback principle comparable to that of algorithms commonly applied within control theory of dynamic systems. The boundary conditions are defined in...

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of the master osteoblast transcription factor, RUNX2. We find that ex vivo deletion of sirt1 leads to decreased expression of runx2 downstream targets, but not runx2 itself, along with reduced...

Identification of pterygium-related mRNA expression profiling by microarray analysis

PurposePterygium is a common degenerative and proliferative disease of the ocular surface. In some severe cases, pterygium may lead to irregular corneal astigmatism and corneal stromal scarring with visual impairment. The proliferative capacities of pterygial cells make them appear similar to tumorigenesis. Although considerable progress has been made towards understanding the...

Failure Analysis of Multilayered Suspension Plasma-Sprayed Thermal Barrier Coatings for Gas Turbine Applications

Improvement in the performance of thermal barrier coatings (TBCs) is one of the key objectives for further development of gas turbine applications. The material most commonly used as TBC topcoat is yttria-stabilized zirconia (YSZ). However, the usage of YSZ is limited by the operating temperature range which in turn restricts the engine efficiency. Materials such as pyrochlores...