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Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma

Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the treatment of asthma. The anti-inflammatory effects are mediated either by direct binding of the glucocorticoid/glucocorticoid receptor complex to glucocorticoid responsive elements in the promoter region of genes, or by an interaction of this complex with other transcription factors, in...

The contribution of mutations in MYH7 to the onset of cardiomyopathy

, Amsterdam , The Netherlands 1 J. van der Velden - In this issue of the Netherlands Heart Journal, van der Linde et al. describe a novel Dutch founder mutation (MYH7p.Asn1918Lys) in MYH7, the gene encoding

Life-long tailoring of management for patients with hypertrophic cardiomyopathy

5 0 Careggi University Hospital , Florence , Italy 1 Thoraxcenter, Department of Cardiology, Erasmus MC , Rotterdam , The Netherlands 2 J. van der Velden 3 Netherlands Heart Institute , Utrecht , The ... Cardiovascular Research Initiative: An initiative supported by the Netherlands Heart Foundation, CVON2014-40 DOSIS. Conflict of interest M. Michels, I. Olivotto, F.W. Asselbergs and J. van der Velden declare that

Heart failure with preserved ejection fraction: current status and challenges for the future

Heart Institute , Utrecht , The Netherlands 1 Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center , Amsterdam , The Netherlands 2 J. van der Velden 3

Evaluation of the role of Care Sport Connectors in connecting primary care, sport, and physical activity, and residents’ participation in the Netherlands: study protocol for a longitudinal multiple case study design

for a longitudinal multiple case study design E. Smit 0 K.E.F. Leenaars M.A.E. Wagemakers G.R.M. Molleman 0 M.A. Koelen J. van der Velden 0 0 Academic Collaborative Centre AMPHI, Primary Health Care

Troponin I phosphorylation in human myocardium in health and disease

Hamburg-Eppendorf , Hamburg, Germany 2 J. van der Velden ICIN-Netherlands Heart Institute , Utrecht, the Netherlands 3 G. J. M. Stienen Department of Physics and Astronomy, VU University , Amsterdam, the

Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

AffiliationsDepartment of Immunology, Erasmus MC, University Medical Center Rotterdam, The NetherlandsMagdalena B. Rother, Mirjam van der Burg, Fleur S. van de Bovenkamp, Roel Kroek, Vincent H. J. van der Velden, Jacques ... • PubMed • Google ScholarSearch for Vincent H. J. van der Velden in:Nature Research journals • PubMed • Google ScholarSearch for Tom Cupedo in:Nature Research journals • PubMed • Google ScholarSearch for Ole

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

Jos L. J. van der Velden, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, and Nasreen Khalil have declared that no con‑ flicts of interest exist. Yvonne M. W

Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma

potentially infinite number of dimensions . Cytometry A 2008 ; 73 : 834 - 846 . 44 Kalina T , Flores-Montero J , van der Velden VH , Martin-Ayuso M , Bottcher S , Ritgen M et al. EuroFlow standardization of ... flow cytometer instrument settings and immunophenotyping protocols . Leukemia 2012 ; 26 : 1986 - 2010 . 45 van Dongen JJ , Lhermitte L , Bottcher S , Almeida J , van der Velden VH , Flores-Montero J et

Targeted Drug Delivery by Gemtuzumab Ozogamicin: Mechanism-Based Mathematical Model for Treatment Strategy Improvement and Therapy Individualization

Gemtuzumab ozogamicin (GO) is a chemotherapy-conjugated anti-CD33 monoclonal antibody effective in some patients with acute myeloid leukemia (AML). The optimal treatment schedule and optimal timing of GO administration relative to other agents remains unknown. Conventional pharmacokinetic analysis has been of limited insight for the schedule optimization. We developed a mechanism...

Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function

Primary chronic kidney disease is associated with high cardiovascular risk. However, the exact mechanisms behind this cardiorenal interaction remain unclear. We investigated the interaction between heart and kidneys in novel animal model for cardiorenal interaction. Normal Wistar rats and Munich Wistar Fromter rats, spontaneously developing renal dysfunction, were subjected to...

Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes

The phosphorylation status of myofibrillar proteins influences the Ca2+ responsiveness of the myofilaments,but the contribution of and the interaction between the individual components is poorly characterized. Therefore, in Langendorff perfused rat hearts (n=30), the phosphorylation levels of cardiac myosin binding protein-C (cMyBP-C), troponin I and T (cTnI, cTnT) and myosin...

Non-adherence to antimicrobial treatment guidelines results in more broad-spectrum but not more appropriate therapy

Mortality in patients admitted with sepsis is high and the increasing incidence of infections with multiresistant bacteria is a worldwide problem. Many hospitals have local antimicrobial guidelines to assure effective treatment and limit the use of broad-spectrum antibiotics, thereby reducing the selection of resistant bacteria. We evaluated adherence to the antimicrobial...

Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting

Flow-cytometric detection of minimal residual disease (MRD) has proven in several single-institute studies to have an independent prognostic impact. We studied whether this relatively complex approach could be performed in a multicenter clinical setting. Five centers developed common protocols to accurately define leukemia-associated (immuno)phenotypes (LAPs) at diagnosis...

Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer—Gynaecological Cancer Group)

) from Belgium. acknowledgements We would like to thank the following investigators for supporting and contributing to this study: J. van der Velden (Amsterdam), I. Vergote (Leuven), N. Reed (Glasgow), C