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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma

provided laboratory space for Lipidomics Facility in MUSC?s Children?s Research Institute. Author Contributions Conceptualization: Aiping Bai, Yusuf A. Hannun. Formal analysis: Aiping Bai, Jacek Bielawski ... . Funding acquisition: Yusuf A. Hannun. Investigation: Aiping Bai, Xiang Liu. Resources: Aiping Bai, Jacek Bielawski, Yusuf A. Hannun. Supervision: Jacek Bielawski, Yusuf A. Hannun. Writing ? original

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

Bielawski 4 Michael Finnegan 3 Russell Petty 0 0 Division of Cancer Research, School of Medicine, University of Dundee, Mailbox 4, Level 7 Ninewells Hospital and Medical School , Dundee DD1 9SY Scotland , UK

2-hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase

Fatty acid 2-hydroxylase (FA2H) is the enzyme responsible for the hydroxylation of free fatty acids prior to their incorporation into 2-hydroxylated sphingolipids, which are the major constituents of the myelin leaflet. Mutated FA2H has been associated with neurodegenerative diseases. Decreased FA2H activity was demonstrated only in vitro, but not in patient tissues. In this...

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

Background Ceramide is a bioeffector that mediates various cellular processes, including apoptosis. However, the mechanism underlying ceramide function in apoptosis is apparently cell type-dependent and is not well-understood. We aimed at identifying molecular targets of ceramide in metastatic human colon and breast cancer cells, and determining the efficacy of ceramide analog in...

C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Killing Duska Separovic,1,2 Ziad H. Saad,1 Ethan A. Edwin,1 Jacek Bielawski,3 Jason S. Pierce,3 Eric Van Buren,2 and Alicja Bielawska3 1Department of Pharmaceutical Sciences, Eugene Applebaum College of

C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Killing Duska Separovic,1,2 Ziad H. Saad,1 Ethan A. Edwin,1 Jacek Bielawski,3 Jason S. Pierce,3 Eric Van Buren,2 and Alicja Bielawska3 1Department of Pharmaceutical Sciences, Eugene Applebaum College of

Erratum: Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

err Atu M 0 0 R David Sentelle, Can E Senkal, Wenhui Jiang, Suriyan Ponnusamy, Salih Gencer, Shanmugam Panneer Selvam, Venkat K Ramshesh, Yuri K Peterson, John J Lemasters, Zdzislaw M Szulc, Jacek ... Bielawski & Besim Ogretmen g p n In the version of this article initially published, one of the institute affiliations of co-first author Xu Zhao and coauthors Ying Yang and Yun-Gui Yang was not included

Stress-Induced Sphingolipid Signaling: Role of Type-2 Neutral Sphingomyelinase in Murine Cell Apoptosis and Proliferation

Background Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different acidic or neutral sphingomyelinases. This study was carried out to investigate whether the neutral Mg2+-dependent neutral...

Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse

The pharmacological chaperone, isofagomine (IFG), enhances acid β-glucosidase (GCase) function by altering folding, trafficking, and activity in wild-type and Gaucher disease fibroblasts. The in vivo effects of IFG on GCase activity, its substrate levels, and phenotype were evaluated using a neuronopathic Gaucher disease mouse model, 4L;C* (V394L/V394L + saposin C-/-) that has...

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk

The adipose tissue has become a central focus in the pathogenesis of obesity-mediated cardiovascular and metabolic disease. Here we demonstrate that adipose sphingolipid metabolism is altered in genetically obese (ob/ob) mice. Expression of enzymes involved in ceramide generation (neutral sphingomyelinase [NSMase], acid sphingomyelinase [ASMase], and serine-palmitoyl-transferase...