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A Review of the Challenges of Using Biomedical Big Data for Economic Evaluations of Precision Medicine

There is potential value in incorporating biomedical big data (BBD)—observational real-world patient-level genomic and clinical data in multiple sub-populations—into economic evaluations of precision medicine. However, health economists face practical and methodological challenges when using BBD in this context. We conducted a literature review to identify and summarise these...

Responding to Crisis: Risk, Opportunity and Strategic Wagers

Responding to Crisis: Risk , Opportunity and James Buchanan Follow this and additional works at: Recommended Citation - Responding to Crisis Risk ... , Opportunity and Strategic Wagers By James Buchanan T throes of serious sis? The presidents and boards here is a great deal of us that we take action, that of debate about we make changes, maybe even whether

The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study

to the interpretation of the results. James Buchanan contributed to the design of the study and the interpretation of the results, and drafted the manuscript. Jose? Leal acts as the overall guarantor ... for this work. Compliance with Ethical Standards Conflict of interest Jose? Leal, Stefania Manetti and James Buchanan declare that they have no conflicts of interest. Funding This project was funded

Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature

PurposeWe conducted a systematic literature review to summarize the current health economic evidence for whole-exome sequencing (WES) and whole-genome sequencing (WGS).MethodsRelevant studies were identified in the EMBASE, MEDLINE, Cochrane Library, EconLit and University of York Centre for Reviews and Dissemination databases from January 2005 to July 2016. Publications were...

Using Genomic Information to Guide Ibrutinib Treatment Decisions in Chronic Lymphocytic Leukaemia: A Cost-Effectiveness Analysis

Hospitals Trust , Oxford , UK 1 Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford , Old Road Campus, Headington, Oxford OX3 7LF , UK 2 & James Buchanan 3 ... This paper represents independent research arising from a Doctoral Research Fellowship awarded to James Buchanan and supported by the National Institute for Health Research (NIHR). Sarah Wordsworth

Patients’ Preferences for Genomic Diagnostic Testing in Chronic Lymphocytic Leukaemia: A Discrete Choice Experiment

, Old Road Campus, Headington, Oxford OX3 7LF , UK 2 & James Buchanan 3 Key Points for Decision Makers 4 Department of Oncology, University of Oxford , Oxford , UK Background Genomic information could ... provided helpful advice on the design of the discrete choice experiment. Any errors or omissions are the sole responsibility of the authors. Author contributions James Buchanan initiated and led the study

Women’s birth place preferences in the United Kingdom: a systematic review and narrative synthesis of the quantitative literature

Yangmei Li 0 Reem Malouf 0 James Buchanan 1 0 Policy Research Unit in Maternal Health and Care, National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford , Old

Safety and tolerability of etirinotecan pegol in advanced breast cancer: analysis of the randomized, phase 3 BEACON trial

8 Ahmad Awada 7 Edith A. Perez 6 Seock‑Ah Im 5 Carol Zhao 10 Ute Hoch 10 Denise Tomkinson 10 James Buchanan 10 Mary Tagliaferri 10 Alison Hannah 9 Joyce O'Shaughnessy 3 0 Vall d'Hebron Institute of

Cost-Effectiveness of Pre-Referral Antimalarial, Antibacterial, and Combined Rectal Formulations for Severe Febrile Illness

Background Malaria and bacterial infections account for most infectious disease deaths in developing countries. Prompt treatment saves lives, but rapid deterioration often prevents the use of oral therapies; delays in reaching health facilities providing parenteral interventions are common. Rapidly and reliably absorbed antimalarial/antibacterial rectal formulations used in the...

Diagnosing idiopathic learning disability: a cost-effectiveness analysis of microarray technology in the National Health Service of the United Kingdom

Array based comparative genomic hybridisation (aCGH) is a powerful technique for detecting clinically relevant genome imbalance and can offer 40 to > 1000 times the resolution of karyotyping. Indeed, idiopathic learning disability (ILD) studies suggest that a genome-wide aCGH approach makes 10–15% more diagnoses involving genome imbalance than karyotyping. Despite this, aCGH has...

Ohio Landlord-Tenant Reform Revisited

; //engagedscholarship; csuohio; edu/clevstlrev OHIO LANDLORD-TENANT REFORM REVISITED EDWARD G. KRAMER* MARILYN TOBOCMAN** KENNETH J. KOWALSKI*** JAMES BUCHANAN**** 158 159 160 161 165 170 177 183 188 188 188 190 196

Reforming the Mobile Home Tenant-Landlord Relationship: The Ohio Experience

; csuohio; edu/clevstlrev JAMES BUCHANAN** MARILYN TOBOCMAN SOBOL*** I. INTRODUCTION M OBILE HOMES HAVE BECOME THE FASTEST GROWING SECTOR of the housing market. It is estimated that ten million Americans