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51 papers found.
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Results from e-KISS: electronic-KIOSK Intervention for Safer Sex: A pilot randomized controlled trial of an interactive computer-based intervention for sexual health in adolescents and young adults

, Matthew R. Golden. Formal analysis: Taraneh Shafii, Samantha K. Benson, James P. Hughes, Matthew R. Golden, King K. Holmes. Funding acquisition: Taraneh Shafii, Diane M. Morrison, Matthew R. Golden, King ... K. Holmes. Investigation: Taraneh Shafii, Diane M. Morrison, James P. Hughes, Matthew R. Golden, King K. Holmes. Methodology: Taraneh Shafii, Diane M. Morrison, James P. Hughes, Matthew R. Golden

HIV-1 diversity among young women in rural South Africa: HPTN 068

H. Eshleman, Mary Formal analysis: Mariya V. Sivay, Jing Wang, James P. Hughes, Mary Kathryn Grabowski. Funding acquisition: Susan H. Eshleman, Mary Kathryn Grabowski. Investigation: Mariya V. Sivay ... . Validation: Erica L. Hamilton, Amanda Selin, James P. Hughes. Visualization: Mariya V. Sivay. Writing ? original draft: Mariya V. Sivay, Susan H. Eshleman, Mary Kathryn Grabowski. Writing ? review & editing

Executive function associated with sexual risk in young South African women: Findings from the HPTN 068 cohort

Conceptualization: Molly Rosenberg, Audrey Pettifor, Mihaela Duta, Nele Demeyere, Ryan G. Wagner, Amanda Selin, Catherine MacPhail, Oliver Laeyendecker, James P. Hughes, Alan Stein, Stephen Tollman, Kathleen Kahn ... , Amanda Selin, Catherine MacPhail, James P. Hughes, Stephen Tollman, Kathleen Kahn. Investigation: Audrey Pettifor, Nele Demeyere, Ryan G. Wagner, Amanda Selin, Catherine MacPhail, Oliver Laeyendecker

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

N. Bumpus. Investigation: Dominique B. Figueroa, Joseph Tillotson, Craig W. Hendrix, Timothy H. Holtz, Linda-Gail Bekker, Frits van Griensven, Sharon Mannheimer, James P. Hughes, Robert M. Grant ... P. Hughes, Robert M. Grant, Namandje N. Bumpus. 16 / 18 17 / 18 1. Schooley RT , Ruane P , Myers RA , Beall G , Lampiris H , Berger D , et al. Tenofovir DF in antiretroviralexperienced patients

Incident Detection of High-Risk Human Papillomavirus Infections in a Cohort of High-Risk Women Aged 25–65 Years

Background. The risk of incident high-risk human papillomavirus (HR-HPV) infection associated with recent sexual behaviors is undefined in mid-adult women (defined as women aged 25–65 years). Methods. Triannually, 420 female online daters aged 25–65 years submitted vaginal specimens for HPV testing and completed health and sexual behavior questionnaires. The cumulative incidence...

A unified procedure for meta-analytic evaluation of surrogate end points in randomized clinical trials

JAMES Y. DAI 0 1 0 JAMES P. HUGHES Department of Biostatistics, University of Washington , WA 98195 , USA 1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle

Uptake and Population-Level Impact of Expedited Partner Therapy (EPT) on Chlamydia trachomatis and Neisseria gonorrhoeae: The Washington State Community-Level Randomized Trial of EPT

Background Expedited partner therapy (EPT), the practice of treating the sex partners of persons with sexually transmitted infections without their medical evaluation, increases partner treatment and decreases gonorrhea and chlamydia reinfection rates. We conducted a stepped-wedge, community-level randomized trial to determine whether a public health intervention promoting EPT...

Estimating the Efficacy of Preexposure Prophylaxis for HIV Prevention Among Participants With a Threshold Level of Drug Concentration

, Seattle, WA 98109 ( 2 Author affiliations: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, Washington (James Y. Dai, Peter B. Gilbert, James P. Hughes , Elizabeth ... R. Brown); and Department of Biostatis- tics, School of Public Health, University of Washington , Seattle, Washington (James Y. Dai, Peter B. Gilbert, James P. Hughes, Elizabeth R. Brown) American

Acyclovir Prophylaxis Reduces the Incidence of Herpes Zoster Among HIV-Infected Individuals: Results of a Randomized Clinical Trial

Human immunodeficiency virus (HIV)–infected persons have higher rates of herpes zoster than HIV-uninfected individuals. We assessed whether twice daily treatment with 400 mg of oral acyclovir reduces the incidence of herpes zoster in a randomized, double-blind, placebo-controlled trial among 3408 persons coinfected with HIV and herpes simplex virus type 2. During 5175 person...

The Relationship between Alcohol Outlets, HIV Risk Behavior, and HSV-2 Infection among South African Young Women: A Cross-Sectional Study

Background Alcohol consumption has a disinhibiting effect that may make sexual risk behaviors and disease transmission more likely. The characteristics of alcohol-serving outlets (e.g. music, dim lights, lack of condoms) may further encourage risky sexual activity. We hypothesize that frequenting alcohol outlets will be associated with HIV risk. Methods In a sample of 2,533...

Antiretroviral Drug Use in a Cohort of HIV-Uninfected Women in the United States: HIV Prevention Trials Network 064

Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009–2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15...

Summary Measures of Adherence Using Pill Counts in Two HIV Prevention Trials: The Need for Standardisation in Reporting

For trials of user-dependent HIV prevention products, accurate adherence measurements are essential to interpret and compare results across trials. We used pill count data from two recent HIV prevention trials of herpes simplex virus type 2 (HSV-2) suppression, to show that estimates of adherence vary substantially depending on assumptions that are made in analysing pill count...

Understanding the Potential Impact of a Combination HIV Prevention Intervention in a Hyper-Endemic Community

Objectives Despite demonstrating only partial efficacy in preventing new infections, available HIV prevention interventions could offer a powerful strategy when combined. In anticipation of combination HIV prevention programs and research studies we estimated the population-level impact of combining effective scalable interventions at high population coverage, determined the...

Using Plasma Viral Load to Guide Antiretroviral Therapy Initiation to Prevent HIV-1 Transmission

, USA: Connie Celum (principal investigator), Anna Wald (protocol co-chair), Jairam Lingappa (medical director), Jared M. Baeten, Mary Campbell, Lawrence Corey, Robert W. Coombs, James P. Hughes, Amalia

HBV Infection in Relation to Consistent Condom Use: A Population-Based Study in Peru

Background Data on hepatitis B virus (HBV) prevalence are limited in developing countries. There is also limited information of consistent condom use efficacy for reducing HBV transmission at the population level. The study goal was to evaluate the prevalence and factors associated with HBV infection in Peru, and the relationship between anti-HBc positivity and consistent condom...

Contingency management to reduce methamphetamine use and sexual risk among men who have sex with men: a randomized controlled trial

Hughes 0 Grant N Colfax Steven Shoptaw Matthew R Golden 0 0 Center for AIDS and STD, Harborview Medical Center , 325 Ninth Avenue, Seattle, WA, 98104 , USA Background: Methamphetamine use is associated

Use of a Multifaceted Approach to Analyze HIV Incidence in a Cohort Study of Women in the United States: HIV Prevention Trials Network 064 Study

Background. Reliable methods for estimating the incidence of human immunodeficiency virus (HIV) infection are needed to monitor the epidemic, identify at-risk populations, and evaluate HIV prevention strategies. We used a multifaceted approach to estimate HIV incidence in the HIV Prevention Trials Network (HPTN) 064 study. Methods. The HPTN 064 study enrolled 2067 HIV...

An assessment of the accuracy and availability of data in electronic patient tracking systems for patients receiving HIV treatment in central Mozambique

Background Since the rapid scale-up of antiretroviral therapy (ART) programs in sub-Saharan Africa, electronic patient tracking systems (EPTS) have been deployed to respond to the growing demand for program monitoring, evaluation and reporting to governments and donors. These routinely collected data are often used in epidemiologic and operations research studies intended to...

Standard Treatment Regimens for Nongonococcal Urethritis Have Similar but Declining Cure Rates: A Randomized Controlled Trial

Background. Azithromycin or doxycycline is recommended for nongonococcal urethritis (NGU); recent evidence suggests their efficacy has declined. We compared azithromycin and doxycycline in men with NGU, hypothesizing that azithromycin was more effective than doxycycline. Methods. From January 2007 to July 2011, English-speaking males ≥16 years, attending a sexually transmitted...

Comparison of Incident Cervical and Vulvar/Vaginal Human Papillomavirus Infections in Newly Sexually Active Young Women

Rachel L. Winer James P. Hughes Qinghua Feng 0 Sandra O'Reilly Nancy B. Kiviat 0 Laura A. Koutsky 0 Pathology, University of Washington , Seattle Vulvar/vaginal human papillomavirus (HPV) infections