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29 papers found.
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Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes

. Freedman. Data curation: Gary C. Chan, Carl D. Langefeld, Jianzhao Xu, S. Carrie Smith, J. Jeffrey Carr, Leon Lenchik, Barry I. Freedman. Formal analysis: Jasmin Divers, Gregory B. Russell, Lynne E ... . Wagenknecht, Barry I. Freedman. Funding acquisition: Barry I. Freedman. Methodology: Jasmin Divers, Thomas C. Register, Leon Lenchik. Project administration: S. Carrie Smith, Donald W. Bowden, Barry I

Bootstrap Interval Estimation of Reliability via Coefficient Omega

is an Assistant Professor of Quantitative Psychology in the Department of Psychology. His research interests are in applied statistics and psychometrics. Email him at: . Jasmin Divers is an Associate

APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans

Background Despite evidence of an association between variants at the apolipoprotein L1 gene (APOL1) locus and a spectrum of related kidney diseases, underlying biological mechanisms remain unknown. An earlier preliminary study published by our group showed that an APOL1 variant (rs73885319) modified the association between high-density lipoprotein cholesterol (HDLC) and...

Montreal Cognitive Assessment and Modified Mini Mental State Examination in African Americans

the paper, and obtaining funding. Jasmin Divers had a role in study design, statistical analysis, interpretation of data, critical revision of the paper, and obtaining funding. Acknowledgments This ... study was funded by NIH R01 NS075107 (Jasmin Divers, Joseph A. Maldjian, and Barry I. Freedman), R01 NS-058700 (Donald W. Bowden), and R01 DK-071891 (Barry I. Freedman). References J. M. Ortman, V. A

Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes

Background Apolipoprotein L1 gene (APOL1) G1 and G2 renal-risk variants, common in populations with recent African ancestry, are strongly associated with non-diabetic nephropathy, end-stage kidney disease, and shorter allograft survival in deceased-donor kidneys (autosomal recessive inheritance). Circulating APOL1 protein is synthesized primarily in the liver and hydrodynamic...

Gene–gene interactions in APOL1-associated nephropathy

Background Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non-diabetic ESKD were...

Cerebral Structural Changes in Diabetic Kidney Disease: African American–Diabetes Heart Study MIND

OBJECTIVE Albuminuria and reduced kidney function are associated with cognitive impairment. Relationships between nephropathy and cerebral structural changes remain poorly defined, particularly in African Americans (AAs), a population at higher risk for both cognitive impairment and diabetes than European Americans. We examined the relationship between urine albumin:creatinine...

Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic disparities. We examined a multi-ethnic sample of 253 healthy children to evaluate associations between insulin-related phenotypes and...

Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND)

. Williams 0 Robert C. Elston Pankaj Kumar 0 William C. Knowler 0 Hanna E. Abboud Sharon Adler Donald W. Bowden Jasmin Divers Barry I. Freedman Robert P. Igo Jr. Eli Ipp Sudha K. Iyengar Paul L. Kimmel Michael

Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

Background Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D). Methods Serum MCP-1 concentration, urine...

Prevalence of Diabetes in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study

OBJECTIVE To estimate the prevalence of diabetes in U.S. youth aged <20 years in 2009 and to estimate the total number of youth with diabetes in the U.S. by age, race/ethnicity, and diabetes type.

Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-up Cohort: A pilot study

. MARTIN RN MS 0 RONNY A. BELL PHD 7 JASMIN DIVERS PHD 1 DANA DABELEA PHD 6 DAVID J. PETTITT 5 SHARON SAYDAH PHD 4 0 Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor

Transcriptomic profiles of aging in purified human immune cells

Fu Liu Craig Johnson R Graham Barr Thomas C Register Kathleen M Donohue Monica V Talor Daniela Cihakova Charles Gu Jasmin Divers David Siscovick Gregory Burke 0 Wendy Post Steven Shea David R Jacobs Jr

Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans

Background. Polymorphisms in the non-muscle myosin IIA gene (MYH9) are associated with focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease (ESRD) in African Americans and FSGS in European Americans. We tested for association of single nucleotide polymorphisms (SNPs) in MYH9 with T2DM–ESRD in European Americans; additionally, three APOL1 gene...

Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)

Background Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained from the Multi-Ethnic Study of Atherosclerosis (MESA), which...

Ethnic Differences in the Relationship Between Albuminuria and Calcified Atherosclerotic Plaque: The African American-Diabetes Heart Study


Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans

Background. Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with non-diabetic nephropathy in African Americans. ApoL1 proteins associate with high-density lipoprotein (HDL) particles in the circulation. Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially...

Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

Miche` le M. Sale Lingyi Lu Ida J. Spruill Jyotika K. Fernandes Kerry H. Lok Jasmin Divers Carl D. Langefeld W. Timothy Garvey OBJECTIVE-The Gullah-speaking African American population from the Sea