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39 papers found.
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Selective colony area method for heterogeneous patient-derived tumor cell lines in anti-cancer drug screening system

authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Author Contributions Conceptualization: Jeeyun Lee. Formal analysis: Dong ... Woo Lee, Jeeyun Lee. Investigation: Jeeyun Lee. Methodology: Ju-Sun Kim, Dong Woo Lee, Jeeyun Lee. Resources: Jeeyun Lee. Validation: Jung Yong Hong, Dong Woo Lee, Jeeyun Lee. Visualization: Dong

Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans

. Data curation: Sang Yun Ha, Ji-Young Song, Yu Jin Kim, Eun Hee Lee, Jeeyun Lee, Yoon-La Choi. Formal analysis: Ensel Oh, Mi Jeong Kwon, Ji-Young Song, Jong-Sun Choi, Yoon-La Choi. Funding acquisition

Capecitabine in combination with either cisplatin or weekly paclitaxel as a first-line treatment for metastatic esophageal squamous cell carcinoma: a randomized phase II study

Background The aim of this study was to assess the efficacy and safety of a combination regimen of capecitabine plus cisplatin (CC) or capecitabine plus paclitaxel (CP) as a first-line treatment in patients with metastatic esophageal squamous cell carcinoma. Methods Patients with recurrent or metastatic esophageal squamous cell carcinoma were enrolled in this open-label, phase II...

Phase I trial and pharmacokinetic study of tanibirumab, a fully human monoclonal antibody to vascular endothelial growth factor receptor 2, in patients with refractory solid tumors

Background Tanibirumab is a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted a first-in-human phase I study of tanibirumab in patients with solid tumors refractory to standard chemotherapy. Primary endpoints were evaluating safety, pharmacokinetics (PKs), estimating maximum-tolerated dose (MTD) and recommended phase II dose...

Copy Number Gains at 8q24 and 20q11-q13 in Gastric Cancer Are More Common in Intestinal-Type than Diffuse-Type

The present study was aimed at discovering DNA copy number alterations (CNAs) involved in the carcinogenesis of stomach and at understanding their clinicopathological significances in the Korean population. DNA copy numbers were analyzed using Agilent 244K or 400K array comparative genomic hybridization (aCGH) in fresh-frozen tumor and matched normal tissues from 40 gastric...

The Impact of Concomitant Genomic Alterations on Treatment Outcome for Trastuzumab Therapy in HER2-Positive Gastric Cancer

Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical outcome of trastuzumab-treated patients. Using...

Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer

Background The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer (BTC) patients receiving gemcitabine plus oxaliplatin (GEMOX), with or without erlotinib. Methods This was a multicenter, open label, randomized, phase III trial...

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Scholar Search for Wenbin Liu in:Nature Research journals • PubMed • Google Scholar Search for Jeeyun Lee in:Nature Research journals • PubMed • Google Scholar Search for Won Ki Kang in:Nature Research

Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan

Background More than half of the patients selected based on KRAS mutation status fail to respond to the treatment with cetuximab in metastatic colorectal cancer (mCRC). We designed a study to identify additional biomarkers that could act as indicators for cetuximab treatment in mCRC. Methods We investigated 58 tumor samples from wild type KRAS CRC patients treated with cetuximab...

Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Scholar Search for Jeeyun Lee in:Nature Research journals • PubMed • Google Scholar Search for Seung Tae Kim in:Nature Research journals • PubMed • Google Scholar Search for Myung-Ju Ahn in:Nature

Genetic Aberrations in Imatinib-Resistant Dermatofibrosarcoma Protuberans Revealed by Whole Genome Sequencing

Dermatofibrosarcoma protuberans (DFSP) is a very rare soft tissue sarcoma. DFSP often reveals a specific chromosome translocation, t(17;22)(q22;q13), which results in the fusion of collagen 1 alpha 1 (COL1A1) gene and platelet-derived growth factor-B (PDGFB) gene. The COL1A1-PDGFB fusion protein activates the PDGFB receptor and resultant constitutive activation of PDGFR receptor...

Statins and the risk of gastric cancer in diabetes patients

Background Several studies have suggested a cancer risk reduction in statin users although the evidence remains weak for stomach cancer. The purpose of this study was to use an exact-matching case–control design to examine the risk of gastric cancer associated with the use of statins in a cohort of patients with diabetes. Methods Cases were defined as patients with incident...

Activated cMET and IGF1R-Driven PI3K Signaling Predicts Poor Survival in Colorectal Cancers Independent of KRAS Mutational Status

Background Oncogenic mutational analysis provides predictive guidance for therapeutics such as anti-EGFR antibodies, but it is successful only for a subset of colorectal cancer (CRC) patients. Method A comprehensive molecular profiling of 120 CRC patients, including 116 primary, 15 liver metastasis, and 1 peritoneal seeding tissue samples was performed to identify the...

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

Next-generation sequencing of cell-free circulating solid tumor DNA addresses two challenges in contemporary cancer care. First this method of massively parallel and deep sequencing enables assessment of a comprehensive panel of genomic targets from a single sample, and second, it obviates the need for repeat invasive tissue biopsies. Digital SequencingTM is a novel method for...

Whole-genome sequencing of matched primary and metastatic hepatocellular carcinomas

Background To gain biological insights into lung metastases from hepatocellular carcinoma (HCC), we compared the whole-genome sequencing profiles of primary HCC and paired lung metastases. Methods We used whole-genome sequencing at 33X-43X coverage to profile somatic mutations in primary HCC (HBV+) and metachronous lung metastases (> 2 years interval). Results In total, 5,027-13...

The impact of KRAS mutations on prognosis in surgically resected colorectal cancer patients with liver and lung metastases: a retrospective analysis

Background KRAS mutations are common in colorectal cancer (CRC). The role of KRAS mutation status as a prognostic factor remains controversial, and most large population-based cohorts usually consist of patients with non-metastatic CRC. We evaluated the impact of KRAS mutations on the time to recurrence (TTR) and overall survival (OS) in patients with metastatic CRC who underwent...

EGFR Mutation Testing in Patients with Advanced Non-Small Cell Lung Cancer: A Comprehensive Evaluation of Real-World Practice in an East Asian Tertiary Hospital

-La Choi Jong-Mu Sun Juhee Cho Sanjay Rampal Joungho Han Bhash Parasuraman Eliseo Guallar Genehee Lee Jeeyun Lee Young Mog Shim Balraj Mittal, Sanjay Gandhi Medical Institute, India Introduction

GSTT1 Copy Number Gain and ZNF Overexpression Are Predictors of Poor Response to Imatinib in Gastrointestinal Stromal Tumors

Oncogenic mutations in gastrointestinal stromal tumors (GISTs) predict prognosis and therapeutic responses to imatinib. In wild-type GISTs, the tumor-initiating events are still unknown, and wild-type GISTs are resistant to imatinib therapy. We performed an association study between copy number alterations (CNAs) identified from array CGH and gene expression analyses results for...

Effect of Simvastatin on Cetuximab Resistance in Human Colorectal Cancer With KRAS Mutations

Jeeyun Lee Inkyoung Lee Boram Han Joon Oh Park Jiryeon Jang Chaehwa Park Won Ki Kang ) Metastatic colorectal cancer (CRC) patients with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS

Aberrant CDK4 Amplification in Refractory Rhabdomyosarcoma as Identified by Genomic Profiling

, KoreaEnsel Oh & Yu Jin Kim AuthorsSearch for Silvia Park in:Nature Research journals • PubMed • Google ScholarSearch for Jeeyun Lee in:Nature Research journals • PubMed • Google ScholarSearch for In-Gu Do ... the manuscript. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Jeeyun Lee or Yoon-La Choi. Supplementary information PDF files1