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Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis

, Jennifer A. Smith, Belinda L. Needham, Bhramar Mukherjee, Erin B. Ware, Sharon L. R. Kardia. Resources: Ana V. Diez-Roux. Writing ? original draft: Kristen M. Brown. Writing ? review & editing: Kristen M ... . Brown, Ana V. Diez-Roux, Jennifer A. Smith, Belinda L. Needham, Bhramar Mukherjee, Erin B. Ware, Yongmei Liu, Steven W. Cole, Teresa E. Seeman, Sharon L. R. Kardia. 12 / 15 13 / 15 14 / 15 1. Link BG

Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling

. Bohjanen. Data curation: Liang Guo. Formal analysis: Liang Guo. Funding acquisition: Paul R. Bohjanen. Methodology: Jennifer A. Smith. Project administration: Paul R. Bohjanen. Supervision: Leslie A ... . Schiff, Paul R. Bohjanen. Validation: Liang Guo. Investigation: Jennifer A. Smith, Michelle Abelson, Irina Vlasova-St. Louis. Writing ? original draft: Liang Guo, Leslie A. Schiff, Paul R. Bohjanen

The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus

Metabolic coherence (MC) is a network-based approach to dimensionality reduction that can be used, for example, to interpret the joint expression of genes linked to human metabolism. Computationally, the derivation of ‘transcriptomic’ MC involves mapping of an individual gene expression profile onto a gene-centric network derived beforehand from a metabolic network (currently...

RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling

Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation. Genome-wide association studies have implied the association of IRF5 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren’s syndrome, inflammatory bowel disease and...

Enhancing health and independent living for veterans with disabilities by leveraging community-based resources

Osorio,1 Jennifer A Smith,1 Elizabeth M Hannold,1,† 1Center of Innovation on Disability and Rehabilitation Research, North Florida/South Georgia Veterans Health System, 2Center for Independent Living of

Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes

Genetic risk scores are a useful tool for examining the cumulative predictive ability of genetic variation on cardiovascular disease. Important considerations for creating genetic risk scores include the choice of genetic variants, weighting, and comparability across ethnicities. Genetic risk scores that use information from genome-wide meta-analyses can successfully predict...

Attitudes toward Genetic Testing for Hypertension among African American Women and Girls

Introduction. Although African American (AA) women have the highest prevalence of hypertension and many genetic studies have been conducted to examine this disparity, no published studies have investigated their attitudes toward genetic testing for hypertension. The purpose of the present study was to use the health belief model as a guide to examine attitudes toward perceived...

Attitudes toward Genetic Testing for Hypertension among African American Women and Girls

Introduction. Although African American (AA) women have the highest prevalence of hypertension and many genetic studies have been conducted to examine this disparity, no published studies have investigated their attitudes toward genetic testing for hypertension. The purpose of the present study was to use the health belief model as a guide to examine attitudes toward perceived...

The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region

Background Recent genome-wide association studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the Chr9p21 region are associated with coronary artery disease (CAD). Most of the SNPs identified in this region are non-coding SNPs, suggesting that they may influence gene expression by cis or trans mechanisms to affect disease susceptibility. Since all cells from...

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

Piyush B. Madhamshettiwar Ronald N. Germain Jennifer A. Smith Kaylene J. Simpson Scott E. Martin Eugen Buehler Iain D.C. Fraser The original version of this article contained an error in the spelling of

Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis

Background RNA interference (RNAi) is an effective and important tool used to study gene function. For large-scale screens, RNAi is used to systematically down-regulate genes of interest and analyze their roles in a biological process. However, RNAi is associated with off-target effects (OTEs), including microRNA (miRNA)-like OTEs. The contribution of reagent-specific OTEs to...

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

, Piyush B. Madhamshettiwar, Ronald N. Germain, Jennifer A. Smith, Kaylene J. Simpson, Scott E. Martin, Eugen Buehler & Iain D.C. Fraser Nature Communications 7:10578 doi: 10.1038/ncomms10578 (2016

Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests

The hormone cortisol is likely to be a key mediator of the stress response that influences multiple physiologic systems that are involved in common chronic disease, including the cardiovascular system, the immune system, and metabolism. In this paper, a candidate gene approach was used to investigate genetic contributions to variability in multiple correlated features of the...

Epigenetic Markers of Renal Function in African Americans

development of novel detection, treatment, or prevention strategies for CKD that will help to decrease the current health disparities in kidney disease. Authors’ Contribution Samantha M. Bomotti and Jennifer A ... . Smith contributed equally to this work. Acknowledgments The authors appreciate technical assistance provided by Jodie L. Van de Rostyne, Pamela I. Hammond, and the Mayo Clinic Advanced Genomics Technology

The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3

Background Single nucleotide polymorphisms (SNPs) within the 9p21.3 genomic region have been consistently associated with coronary heart disease (CHD), myocardial infarction, and quantity of coronary artery calcification (CAC), a marker of subclinical atherosclerosis. Prior studies have established an association between blood pressure measures and CAC. To examine mechanisms by...

Gene-Specific DNA Methylation Association with Serum Levels of C-Reactive Protein in African Americans

A more thorough understanding of the differences in DNA methylation (DNAm) profiles in populations may hold promise for identifying molecular mechanisms through which genetic and environmental factors jointly contribute to human diseases. Inflammation is a key molecular mechanism underlying several chronic diseases including cardiovascular disease, and it affects DNAm profile on...

Meta-analysis of epigenome-wide association studies of cognitive abilities

Bressler, Elena Colicino, Eilis Hanno, Shuo Li, Diddier Prada, Jennifer A. Smith, Letizia Trevisi, Pei-Chien Tsai, Dina Vojinovic, Andrea A. Baccarelli, Jordana T. Bell, Cornelia M. van Duijn, Myriam Fornage ... ://creativecommons. org/licenses/by/4.0/. Affiliations Riccardo E. Marioni1,2,3 ? Allan F. McRae 3,4 ? Jan Bressler5 ? Elena Colicino6,7 ? Eilis Hannon 8 ? Shuo Li Diddier Prada10 ? Jennifer A Smith 11,12 ? Letizia

Genome-Wide Association Study of Gene by Smoking Interactions in Coronary Artery Calcification

Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk...

Understanding the Impact of Male Circumcision Interventions on the Spread of HIV in Southern Africa

BackgroundThree randomised controlled trials have clearly shown that circumcision of adult men reduces the chance that they acquire HIV infection. However, the potential impact of circumcision programmes – either alone or in combination with other established approaches – is not known and no further field trials are planned. We have used a mathematical model, parameterised using...

Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching

Recently, we identified that diverse heavy chain (H-chain)-only IgG is spontaneously produced in light chain (L-chain)-deficient mice (L−/− with silenced κ and λ loci) despite a block in B cell development. In murine H-chain IgG, the first Cγ exon, CH1, is removed after DNA rearrangement and secreted polypeptides are comparable with camelid-type H-chain IgG. Here we show that L...