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Search: authors:"Jenny Rubin"

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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

ObjectiveWe recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect.ResultsMBZ potently binds and inhibits Dual specificity tyrosine-phosphorylation-regulated kinase 1B...