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Agencia de autocuidado de la persona con enfermedad renal crónica en diálisis

-Medina1  , Joselinne de Jesús Blanco-Ochoa1  1Departamento de Enfermería. Facultad de Salud. Universidad Surcolombiana. Neiva. Huila. Colombia RESUMEN Introducción Las personas con

Critical appraisal of rituximab in the maintenance treatment of advanced follicular lymphoma

Critical appraisal of rituximab in the maintenance treatment of advanced follicular lymphoma David Aguiar-Bujanda, María Jesús Blanco-Sánchez, María Hernández-Sosa, Saray Galván-Ruíz, Samuel

The original sins of clinical trials with intravenous immunoglobulins in sepsis

Intravenous immunoglobulins (IVIGs) have not yet demonstrated robust evidence in the benefit for treatment of sepsis. In spite of multiple clinical trials performed with IVIG in sepsis, it remains an experimental therapy for this severe condition. Nonetheless, these trials do not address a number of potential confounding factors, concerning both the patient and the IVIG...

Neurally adjusted ventilatory assist in patients with acute respiratory failure: study protocol for a randomized controlled trial

Committee: Jesús Villar, Javier Belda, Fernando Suárez-Sipmann, José Manuel Añón, Jesús Blanco, Lina Pérez-Méndez, and Robert M. Kacmarek. Data and Safety Monitoring Board: Pedro de la Oliva, Paolo Pelosi ... , Spain); José Rubio (Hospital Puerta del Mar, Cádiz, Spain); David Pestaña, Nilda Martínez, Ángel Candela, and Pilar Cobeta (Hospital Universitario Ramón y Cajal, Madrid, Spain); Lorena Fernández, Jesús

The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

. Researchers of the GRECIA group (Coordinator: Jesús Blanco) Marta María García‑ García (Hospital Universitario Río Hortega, Valladolid, Spain); Mª Jesús López Pueyo, Jose Antonio Fernandez Ratero, Miguel Mar

Year in review 2011: Critical Care - respirology

Management of acute respiratory failure is an important component of intensive care. In this review, we analyze 21 original research articles published last year in Critical Care in the field of respiratory and critical care medicine. The articles are summarized according to the following topic categories: acute respiratory distress syndrome, mechanical ventilation, adjunctive...

Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial

, and marked reduction of health care cost. Trial status The first patient was enrolled on 28 March 2013. Expected duration of the study is 50 months. Ana María Prieto, Jesús Blanco (Hospital

Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury

Introduction Endothelial cell injury is an important component of acute lung injury. Platelet-endothelial cell adhesion molecule-1 (PECAM1) is a transmembrane protein that connects endothelial cells to one another and can be detected as a soluble, truncated protein (sPECAM1) in serum. We hypothesized that injurious mechanical ventilation (MV) leads to shedding of PECAM1 from lung...

Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis

Adalia, Eli Zavala, Julia Martínez, Antoni Torres, Joan Badia (Hospital Clínic, Barcelona); and Francisco Alba, Ruth Corpas (Hospital Nuestra Señora del Prado, GRECIA investigators Jesús Blanco, Arturo

Circulating neutrophil counts and mortality in septic shock

Maria Fe Muñoz 2 María Heredia-Rodríguez 1 Rafael Citores 5 José Ignacio Gómez-Herreras 1 Jesús Blanco 3 4 for the EXPRESS (Expresión Génica en Sepsis) GRECIA (Grupo de Estudios y Análisis en Cuidados

Disfonía y Lumbalgia como presentación de Sarcoma Granulocítico: Primera manifestación de Leucemia Mieloide Aguda

. Initial manifestation of Acute Myeloid Leukaemia     Mª Ángeles Carceller Ruiz, Antonia Vera Montes de Oca, Mª Jesús Blanco de La Rubia, Antonio Alberto León Martín Servicio de Urgencias. Hospital

The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation

Purpose While our understanding of the pathogenesis and management of acute respiratory distress syndrome (ARDS) has improved over the past decade, estimates of its incidence have been controversial. The goal of this study was to examine ARDS incidence and outcome under current lung protective ventilatory support practices before and after the diagnosis of ARDS. Methods This was...

Combined Multilocus Sequence Typing and O Serogrouping Distinguishes Escherichia coli Subtypes Associated with Infant Urosepsis and/or Meningitis

The genetic relatedness of 223 invasive Escherichia coli strains that cause either meningitis or urosepsis without meningitis in young infants was determined by multilocus sequence typing (MLST), ribotyping, and phylogenetic polymerase chain reaction grouping. We also determined the serotypes and virulence genotypes (on the basis of 11 virulence genes). The strains belonged to 29...

Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro-Inflammatory Responses during Sepsis

Background Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections. Recently, TLR1 gene polymorphisms have been found correlated with whole blood hyper-inflammatory responses to pathogen-associated molecules and associated with sepsis-associated multiorgan...

Serum Lipopolysaccharide Binding Protein Levels Predict Severity of Lung Injury and Mortality in Patients with Severe Sepsis

Background There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examined whether serial serum levels of LBP could be used as a marker of outcome...

Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study

Introduction Sepsis is a leading cause of admission to non-cardiological intensive care units (ICUs) and the second leading cause of death among ICU patients. We present the first extensive dataset on the epidemiology of severe sepsis treated in ICUs in Spain. Methods We conducted a prospective, observational, multicentre cohort study, carried out over two 3-month periods in 2002...

Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza

Background Severe disease caused by 2009 pandemic influenza A/H1N1virus is characterized by the presence of hypercytokinemia. The origin of the exacerbated cytokine response is unclear. As observed previously, uncontrolled influenza virus replication could strongly influence cytokine production. The objective of the present study was to evaluate the relationship between host...