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Multiscale modeling reveals angiogenesis-induced drug resistance in brain tumors and predicts a synergistic drug combination targeting EGFR and VEGFR pathways

Experimental studies have demonstrated that both the extracellular vasculature or microenvironment and intracellular molecular network (e.g., epidermal growth factor receptor (EGFR) signaling pathway) are important for brain tumor growth. Additionally, some drugs have been developed to inhibit EGFR signaling pathways. However, how angiogenesis affects the response of tumor cells...

Effects of Meshed p-type Contact Structure on the Light Extraction Effect for Deep Ultraviolet Flip-Chip Light-Emitting Diodes

In this work, flip-chip AlGaN-based deep ultraviolet light-emitting diodes (DUV LEDs) with various meshed contact structures are systematically investigated via three-dimensional finite-difference time-domain (3D FDTD) method. It is observed that both transverse electric (TE)- and transverse magnetic (TM)-polarized light extraction efficiencies (LEEs) are sensitive to the spacing...

Discover Gene Specific Local Co-Regulations from Time-Course Gene Expression Data

Scientific Programming Discover gene specific local co-regulations from time-course gene expression data Ji Zhang 1 Qigang Gao 1 Hai Wang 0 0 Sobey School of Business, Saint Mary's University

A novel homodimer laccase from Cerrena unicolor BBP6: Purification, characterization, and potential in dye decolorization and denim bleaching

. Data curation: Ji Zhang, Lei Sun, Hao Zhang. Formal analysis: Ji Zhang, Hao Zhang. Funding acquisition: Anli Geng. Investigation: Ji Zhang, Anli Geng. Methodology: Ji Zhang, Anli Geng. Project ... administration: Anli Geng. Supervision: Anli Geng. Validation: Ji Zhang, Lei Sun, Hao Zhang. Writing ? original draft: Ji Zhang. Writing ? review & editing: Shufang Wang, Xiaoyu Zhang, Anli Geng. 18 / 20 19

The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease

Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3). Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine...

The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease

Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3). Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine...

Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China

A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form...

Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China

A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form...

Does network topology influence systemic risk contribution? A perspective from the industry indices in Chinese stock market

paper. Author Contributions Conceptualization: Haiming Long. Data curation: Nengyu Tang. Formal analysis: Nengyu Tang. Funding acquisition: Haiming Long. Investigation: Ji Zhang. Methodology: Ji Zhang ... . Resources: Haiming Long. Software: Ji Zhang. Supervision: Haiming Long. Visualization: Ji Zhang. Writing ± original draft: Ji Zhang. Writing ± review & editing: Ji Zhang. 17 / 19 18 / 19 1. Kaufman GG

Artificial 137Cs and natural 40K in mushrooms from the subalpine region of the Minya Konka summit and Yunnan Province in China

A study on 137Cs pollution and activity concentrations of 40K in mushrooms of the genera Cortinarius, Leccinum, Russula, Tricholoma, Tylopilus, and Xerocomus from two neighboring regions in southwest China in 2010–2013 revealed different patterns of pollution with 137Cs, which seemed to be highly dependent on climate conditions. Tricholoma matsutake was collected in Yunnan before...

Application of Fourier transform infrared spectroscopy with chemometrics on postmortem interval estimation based on pericardial fluids

forensic field. Author Contributions Ji Zhang and Bing Li wrote the main manuscript and prepared all figures. Yijiu Chen, Ping Huang and Zhenyuan Wang oversaw the project and assisted with the writing of

Radioactive artificial 137Cs and natural 40K activity in 21 edible mushrooms of the genus Boletus species from SW China

This study, for the first time, presents the results of activity concentration determinations for 137Cs and 40K in a high number (21 species, 87 composite samples, and 807 fruiting bodies) of mushrooms of the genus Boletus from across Yunnan in 2011–2014 and Sichuan (Boletus tomentipes) using high-resolution high-purity germanium detector. Activity concentrations of 137Cs...

Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats

The Raw Curcumae Rhizoma (R-CR), included in the Chinese Pharmacopoeia Edition 2015, is a well-known Chinese herbal medicine. However, the vinegar-processed Curcumae Rhizoma (V-CR) is used more widely than R-CR. The pharmacokinetics comparison of R-CR and V-CR after oral administration to rats is poorly understood. A novel method, rapid resolution liquid chromatography-tandem...

UV–Vis and ATR–FTIR spectroscopic investigations of postmortem interval based on the changes in rabbit plasma

, Hancheng Lin. Visualization: Bing Li, Hancheng Lin. Writing ± original draft: Qi Wang. Writing ± review & editing: Ji Zhang, Zhenyuan Wang. 13 / 16 14 / 16 26. Huang P, Tian W, Tuo Y, Wang Z, Yang G

Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells

polished the paper; Ji ZHANG designed and performed the research, analyzed the data and wrote the paper; Yi-rong DING assisted in performing the research. References 1. Wilhelmus MM, van Dam AM ... , Fudan University, Shanghai 200032, ChinaJi Zhang AuthorsSearch for Ji Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Yi-rong Ding in:Nature Research journals • PubMed • Google

Identification of Skin Electrical Injury Using Infrared Imaging: A Possible Complementary Tool for Histological Examination

In forensic practice, determination of electrocution as a cause of death usually depends on the conventional histological examination of electrical mark in the body skin, but the limitation of this method includes subjective bias by different forensic pathologists, especially for identifying suspicious electrical mark. The aim of our work is to introduce Fourier transform...

Numerical Investigation of Acoustic Emission Events of Argillaceous Sandstones under Confining Pressure

At the laboratory scale, locating acoustic emission (AE) events is a comparatively mature method for evaluating cracks in rock materials, and the method plays an important role in numerical simulations. This study is aimed at developing a quantitative method for the measurement of acoustic emission (AE) events in numerical simulations. Furthermore, this method was applied to...

A Comprehensive and Comparative Study of Wolfiporia extensa Cultivation Regions by Fourier Transform Infrared Spectroscopy and Ultra-Fast Liquid Chromatography

Nowadays, Wolfiporia extensa as a popular raw material in food and medicine industry has received increasing interests. Due to supply shortage, this species of edible and medicinal mushroom has been cultivated in some provinces of China. In the present study, cultivated W. extensa collected from six regions in Yunnan Province of China were analyzed by an integrated method based...

Quantitative Analysis in Combination with Fingerprint Technology and Chemometric Analysis Applied for Evaluating Six Species of Wild Paris Using UHPLC-UV-MS

A fast method was developed by ultra high performance liquid chromatography (UHPLC) for simultaneous determination of polyphyllin I and polyphyllin II. Chemometric analyses including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) based on UHPLC chromatography were used to evaluate 38 batches from six species of Paris. Variable...