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Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan

The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability. Understanding the atomic interaction mechanism between chitosan and DNA is important in the design and application of chitosan-based drug and...

Theoretic Study on Dispersion Mechanism of Boron Nitride Nanotubes by Polynucleotides

Due to the unique electrical and mechanical properties of boron nitride nanotubes (BNNT), BNNT has been a promising material for many potential applications, especially in biomedical field. Understanding the dispersion of BNNT in aqueous solution by biomolecules is essential for its use in biomedical applications. In this study, BNNT wrapped by polynucleotides in aqueous solution...

Plasma Fibulin-3 as a Potential Biomarker for Patients with Asbestos-Related Diseases in the Han Population

Yu,1 Yun Xiao,1 Lingfang Feng,1 Lijin Zhu,1 Li Ju,1 Xinnian Guo,1 Yixiao Zhang,1 Jia-Wei Shen,4 Yan Tong,1 Xing Zhang,1 and Jianlin Lou1 1Institute of Occupational Diseases, Zhejiang Academy of

New species and new combinations of Asian Batrisodes Reitter (Coleoptera, Staphylinidae, Pselaphinae), and synonymy of Batrisodellus Jeannel with Batrisodes

Shen 0 Li-Zhen Li 0 0 Department of Biology, College of Life and Environmental Sciences, Shanghai Normal University , Shanghai, 200234 , P. R. China Continuing surveys on the pselaphine fauna in China

Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

Background Gout is a common arthritic disease resulting from elevated serum uric acid (SUA) level. A large meta-analysis including 28,141 individuals identified nine single nucleotide polymorphisms (SNPs) associated with altered SUA level in a Caucasian population. However, raised SUA level alone is not sufficient for the development of gout arthritis and most of these SNPs have...