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Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis

PurposeCD147 is a tumor-associated antigen that plays a key regulatory role in tumor invasion and distant metastasis. However, the exact role of CD147 phosphorylation, which is deregulated during cancer progression, is unknown. Here, the effects of CD147 phosphorylation on the malignant behavior of hepatocellular carcinoma (HCC) cells and its possible underlying mechanisms are...

The Government Incentive Regulation Model and Pricing Mechanism in Power Transmission and Distribution Market

Power University, Baoding, Hebei 071100, China Received 7 January 2016; Accepted 7 March 2016 Academic Editor: Christos K. Volos Copyright © 2016 Huan Zhang and Jian-li Jiang. This is an open access

CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma

Background The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigated the molecular mechanism underlying CD147 induced RhoA deactivation in hepatocellular carcinoma (HCC) cells. Methods Wound-healing assay was performed to study...

N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour metastasis in hepatocellular carcinoma

, Bo Wu, Zhi-Guang Fu, Hao-Miao Shen, Lin Jing, Zhen-Yu Liu, Yang Zhou, Yao Meng, Bao-Qing Xu, Zhi-Nan Chen & Jian-Li Jiang AuthorsSearch for Jiang-Hua Li in:Nature Research journals • PubMed • Google ... ScholarSearch for Jian-Li Jiang in:Nature Research journals • PubMed • Google Scholar Contributions J.-L.J., W.H., P.L. and B.W. contributed to the design of the project, performed the experiments and analysed

Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma

-Min Yang 0 Bao-Qing Xu Fei Feng Bin Wang Qiang Liang Yu Li Yang Zhou Jian-Li Jiang Zhi-Nan Chen 0 Equal contributors Cell Engineering Research Centre & Department of Cell Biology, State Key Laboratory ... : Metal ion-dependent adhesion site; EEA1: Early endosome antigen-1; FRET: Fluorescence resonance energy transfer. Authors’ contributions Jian-Li Jiang and Xiang-Min Yang contributed to the design of the

Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma

CD147-ED as described in our previous work [33]. (JPEG 1123 kb) Competing interests The authors declare that they have no competing interests. Authors’ contributions Jian-Li Jiang and Xiang-Min

HAb18G/CD147 Regulates Vinculin-Mediated Focal Adhesion and Cytoskeleton Organization in Cultured Human Hepatocellular Carcinoma Cells

Jian-Li Jiang 0 Zhi-Nan Chen 0 Kwan Man, The University of Hong Kong, Hong Kong 0 1 Cell Engineering Research Centre and Department of Cell Biology, State Key Discipline of Cell Biology, Fourth

The interaction of HAb18G/CD147 with integrin α6β1 and its implications for the invasion potential of human hepatoma cells

Background HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of HAb18G/CD147 promotes invasion by interacting with integrin α3β1. However, it has never been investigated whether α3β1 is solely responsible for this process or if other integrin family members also...