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Epidemiology of Hepatocellular Carcinoma

Although rare in Canada and the United States, hepatocellular carcinoma (HCC) ranks as the eighth most common cancer in the world. High-risk regions are East and Southeast Asia, and sub-Saharan Africa. Independent of race and geography, rates in men are at least two to three times those in women; this sex ratio is more pronounced in high-risk regions. Rates of HCC in the United...

Epidemiology of Hepatocellular Carcinoma

Although rare in Canada and the United States, hepatocellular carcinoma (HCC) ranks as the eighth most common cancer in the world. High-risk regions are East and Southeast Asia, and sub-Saharan Africa. Independent of race and geography, rates in men are at least two to three times those in women; this sex ratio is more pronounced in high-risk regions. Rates of HCC in the United...

Occupational exposure to endocrine disrupting substances and the risk of breast Cancer: the Singapore Chinese health study

Evidence from basic research links exposure to endocrine disrupting chemicals (EDCs) with a higher risk for breast cancer. However, there is less evidence from observational epidemiological research and the results are equivocal. Therefore, we examined the association between occupational exposure to substances where exposure to EDCs is likely and the risk of breast cancer. A...

Duration of physical activity, sitting, sleep and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study

mortality via database linkages. Author Contributions Conceptualization: Ying Ying Leung, Hamid Rahmatullah Bin Abd Razak, Li-Wei Ang, Jian Min Yuan, Woon-Puay Koh. Data curation: Ying Ying Leung, Li-Wei ... Ang, Woon-Puay Koh. Formal analysis: Mohammad Talaei, Woon-Puay Koh. Funding acquisition: Jian-Min Yuan. Writing ? original draft: Ying Ying Leung, Hamid Rahmatullah Bin Abd Razak, Mohammad Talaei

Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women

Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between FGF-21 and diabetes risk. However, no study has examined whether the association differed by sex, which has been reported between FGF-21 and atherosclerosis. Therefore, we...

ABO blood type and the risk of cancer – Findings from the Shanghai Cohort Study

Conceptualization: Yu-Tang Gao, Jian-Min Yuan. Data curation: Renwei Wang, Yu-Tang Gao, Jian-Min Yuan. Formal analysis: Joyce Yongxu Huang, Renwei Wang. Funding acquisition: Jian-Min Yuan. Investigation: Joyce ... Yongxu Huang, Renwei Wang, Yu-Tang Gao, Jian-Min Yuan. Methodology: Renwei Wang, Yu-Tang Gao, Jian-Min Yuan. Project administration: Yu-Tang Gao, Jian-Min Yuan. Resources: Yu-Tang Gao, Jian-Min Yuan

Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis

in:Nature Research journals • PubMed • Google Scholar Search for Rajiv Chowdhury in:Nature Research journals • PubMed • Google Scholar Search for Jian-Min Yuan in:Nature Research journals • PubMed • Google

A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer

: Joyce Y. Huang, Lesley M. Butler, Jian-Min Yuan. Data curation: Joyce Y. Huang, Renwei Wang. Formal analysis: Joyce Y. Huang, Renwei Wang, Aizhen Jin. Funding acquisition: Jian-Min Yuan. Investigation ... : Joyce Y. Huang, Øivind Midttun, Arve Ulvik, Yu-Tang Gao, Per M. Ueland, Woon-Puay Koh, Jian-Min Yuan. Methodology: Renwei Wang, Jian-Min Yuan. Project administration: Joyce Y. Huang, Jian-Min Yuan

Plasma fatty acids and risk of colon and rectal cancers in the Singapore Chinese Health Study

information AffiliationsCancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USALesley M. Butler, Jian-Min Yuan, Joyce Yongxu Huang & Renwei ... WangDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USALesley M. Butler, Jian-Min Yuan & Joyce Yongxu HuangNUS Environmental Research Institute (NERI

Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking

Among community cohorts, associations between clinical and metabolite factors and complex left atrial (LA) phasic function assessed by cardiac magnetic resonance (CMR) feature tracking (FT) are unknown. Longitudinal LA strain comprising reservoir strain (εs), conduit strain (εe) and booster strain (εa) and their corresponding peak strain rates (SRs, SRe, SRa) were measured using...

Composite protective lifestyle factors and risk of developing gastric adenocarcinoma: the Singapore Chinese Health Study

Background:Incidence of gastric cancer is the highest in Eastern Asia. Multiple modifiable lifestyle factors have been identified as risk factors for gastric cancer. However, their aggregated effect on the risk of gastric cancer has not been examined among populations with high prevalence of Helicobacter pylori.Methods:A study was conducted to examine the association between...

Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study

• Google ScholarSearch for John Carson Allen in:Nature Research journals • PubMed • Google ScholarSearch for Li-Wei Ang in:Nature Research journals • PubMed • Google ScholarSearch for Jian-Min Yuan in:Nature

Gene-diet interaction effects on BMI levels in the Singapore Chinese population

Recent genome-wide association studies (GWAS) have identified 97 body-mass index (BMI) associated loci. We aimed to evaluate if dietary intake modifies BMI associations at these loci in the Singapore Chinese population. We utilized GWAS information from six data subsets from two adult Chinese population (N = 7817). Seventy-eight genotyped or imputed index BMI single nucleotide...

Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study

We aimed to prospectively investigate the bidirectional association between type 2 diabetes (T2D) and gout. We analyzed follow-up data from the Singapore Chinese Health Study, when self-reports of diagnosed diabetes and gout were enquired at follow-ups I and II. Individuals who participated in both follow-ups and were free of cardiovascular disease or cancer at follow-up I were...

Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study

Health Study at Prof Jian-Min Yuan () and Prof Woon Puay Koh () to seek approval from the National University of Singapore IRB. 0.06 and 0.04, respectively). The hypertension to gout association was

Glycated Hemoglobin and Incident Type 2 Diabetes in Singaporean Chinese Adults: The Singapore Chinese Health Study

Background The American Diabetes Association recently included glycated hemoglobin in the diagnostic criteria for diabetes, but research on the utility of this biomarker in Southeast Asians is scant. The aim of this study was to evaluate the association between percent HbA1c and incident diabetes in an Asian population of adult men and women without reported diabetes. Methods...

Determinants of Quality of Life for Breast Cancer Patients in Shanghai, China

patient information, data is available upon request to the corresponding author Dr. Jian-Min Yuan. Funding: This work was supported by award number PWRq2012-24 of the Young Medical Talents Training Program

Elevated Levels of Mercapturic Acids of Acrolein and Crotonaldehyde in the Urine of Chinese Women in Singapore Who Regularly Cook at Home

Lung cancer is unusually common among non-smoking women in Southeastern Asia but the causes of this frequently fatal disease are not well understood. Several epidemiology studies indicate that inhalation of fumes from high temperature Chinese style cooking with a wok may be a cause. Only one previous study investigated uptake of potential toxicants and carcinogens by women who...

Urinary Levels of N-Nitroso Compounds in Relation to Risk of Gastric Cancer: Findings from the Shanghai Cohort Study

Background N-Nitroso compounds are thought to play a significant role in the development of gastric cancer. Epidemiological data, however, are sparse in examining the associations between biomarkers of exposure to N-nitroso compounds and the risk of gastric cancer. Methods A nested case-control study within a prospective cohort of 18,244 middle-aged and older men in Shanghai...