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Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation. Although phosphodiesterases (PDEs) hydrolyzing c-di-GMP and c-di-AMP have been identified, no PDEs for cGAMPs have been reported. Here we identified the first three cGAMP-specific PDEs in V. cholerae (herein designated as V-cGAP1/2/3). V...

Rat and human STINGs profile similarly towards anticancer/antiviral compounds

Foundation of China). Author information Author notesHeng Zhang, Min-Jie Han & Jianli Tao These authors contributed equally to this work. AffiliationsState Key Laboratory of Protein and Plant Gene Research ... , and Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University, Beijing 100871, ChinaHeng Zhang, Min-Jie Han, Jianli Tao, Zhao-Yang Ye, Xiao-Xia Du, Ming-Jing Deng, Xiao-Yan