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Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Geriatric

Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation

Weihong Zhao Jianqing Wu OPEN Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin superfamily, which has been implicated in the pathophysiology of the nervous system. Recently, several

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese Xiaoshuang Ye,1 Lu Wei,1 Xiaohua Pei,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1

Reference Intervals for Serum Cystatin C and Factors Influencing Cystatin C Levels Other than Renal Function in the Elderly

Objective The present study aimed to establish reference intervals for serum cystatin C (Scys-C) stratified by stages of chronic kidney disease, explore factors influencing Scys-C and compare the performance of Scys-C with serum creatinine (Scr) in the young and elderly. Methods A total of 800 participants, 516 young (<60 years) and 284 old (≥60 years) subjects were included in...

Comparisons between the 2012 New CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) Equations and Other Four Approved Equations

Jianqing Wu 0 Weihong Zhao 0 Valquiria Bueno, UNIFESP Federal University of Sao Paulo, Brazil 0 1 Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University

Using Mathematical Algorithms to Modify Glomerular Filtration Rate Estimation Equations

Background The equations provide a rapid and low-cost method of evaluating glomerular filtration rate (GFR). Previous studies indicated that the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease-Epidemiology (CKD-EPI) and MacIsaac equations need further modification for application in Chinese population. Thus, this study was designed to modify the three...

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell...

A Meta-Analysis of Caspase 9 Polymorphisms in Promoter and Exon Sequence on Cancer Susceptibility

Background Caspases are important regulators and executioners in apoptosis pathway and have been defined as either tumor suppressors or oncogenes. Polymorphisms in promoter and exon of caspase 9 were shown to confer genetic susceptibility to multiple cancers, but the results were inconsistent. To accomplish a more precise estimation of the relationship, a meta-analysis was...

Klotho Sensitizes Human Lung Cancer Cell Line to Cisplatin via PI3k/Akt Pathway

Klotho was first identified in 1997 and has been considered as an anti-aging gene. Emerging evidence demonstrates that klotho has a close relationship with cancers, including lung cancer, breast cancer, etc, by inhibiting the proliferation and promoting apoptosis of cancer cells. Cisplatin has been the most widely used drug in the first-line chemotherapy. However, the increase in...

Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis

Weihong Zhao 0 Jianqing Wu 0 Amanda Ewart Toland, Ohio State University Medical Center, United States of America 0 1 Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University

IGF-I and IGFBP-3 and the risk of lung cancer: A meta-analysis based on nested case-control studies

Background Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor growth, respectively. However, there are many different results about their function in some recent epidemiological studies. To evaluate the relationship between...