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Sodium-fluoride PET-CT for the non-invasive evaluation of coronary plaques in symptomatic patients with coronary artery disease: a cross-correlation study with intravascular ultrasound

ObjectivesThe aim of this study was to evaluate the 18F-sodium fluoride (18F-NaF) coronary uptake compared to coronary intravascular ultrasound (IVUS) in patients with symptomatic coronary artery disease.Background18F-NaF PET enables the assessment of vascular osteogenesis by interaction with surface hydroxyapatite, while IVUS enables both identification and quantification of...

Pressure Induced Suppression to the Valence Change Transition in EuPdAs

By applying a hydrostatic pressure, we have successfully suppressed the valence change transition in EuPdAs. The studied compound EuPdAs crystallizes in a P63/mmc space group. Through resistivity and magnetic susceptibility measurements, we find that EuPdAs shows a phase transition at 180 K and another transition below 10 K at ambient pressure, as was reported before. The overall...

Numerical simulation of acoustic wake effect in acoustic agglomeration under Oseen flow condition

We numerically simulate the hydrodynamic interaction of aerosol particles due to the acoustic wake effect under the Oseen flow condition. Attraction is found for two nearby particles with an orientation angle of 0 to 50° with respect to the acoustic field, and weak repulsion is found outside this range. Good agreement is obtained between the numerical results and experiments in...

Effects of the physical and chemical properties of petroleum coke on its slurryability

In this study, the effects of particle size distribution (PSD), chemical composition and pore structure of petroleum coke on the slurryability of petroleum coke water slurry (PCWS) were investigated. Four petroleum cokes were studied, and they showed completely different slurryability. The solid concentration at fixed viscosity (i.e. apparent viscosity of 1000 mPa) (SCFV) of four...

Correlated compositional and mineralogical investigations at the Chang′e-3 landing site

• PubMed • Google ScholarSearch for Chunlai Li in:Nature Research journals • PubMed • Google ScholarSearch for Jianzhong Liu in:Nature Research journals • PubMed • Google ScholarSearch for Jiang Zhang

Proteomic analysis of a disease-resistance-enhanced lesion mimic mutant spotted leaf 5 in rice

Background A lesion-mimic mutant in rice (Oryza sativa L.), spotted leaf 5 (spl5), displays a disease-resistance-enhanced phenotype, indicating that SPL5 negatively regulates cell death and resistance responses. To understand the molecular mechanisms of SPL5 mutation-induced cell death and resistance responses, a proteomics-based approach was used to identify differentially...

Is Autonomic Modulation Different between European and Chinese Astronauts?

Belgian Federal Office of Scientific Affairs. Conceived and designed the experiments: Jiexin Liu YZL BV SGC ZHC YQG Jianzhong Liu JYG QX MY QL AA. Performed the experiments: Jiexin Liu YZL BV SGC ZHC YQG ... Jianzhong Liu JYG QX QL AA. Analyzed the data: Jiexin Liu AA. Contributed reagents/materials/ analysis tools: Jiexin Liu YZL AA. Wrote the paper: Jiexin Liu AA LL. 9. Delp MD (2007) Arterial adaptations in

Detecting differentially methylated loci for Illumina Array methylation data based on human ovarian cancer data

Background It is well known that DNA methylation, as an epigenetic factor, has an important effect on gene expression and disease development. Detecting differentially methylated loci under different conditions, such as cancer types or treatments, is of great interest in current research as it is important in cancer diagnosis and classification. However, inappropriate testing...

The C-Terminal Putative Nuclear Localization Sequence of BReast cancer Metastasis Suppressor 1, BRMS1, Is Necessary for Metastasis Suppression

Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that suppresses metastasis in multiple human and murine carcinoma cell lines. BRMS1 interacts with several nuclear proteins including SIN3:HDAC chromatin remodeling complexes that are involved in repressing transcription. However, recent reports suggest BRMS1 may function in the cytoplasm. BRMS1 has...

Statistical methods on detecting differentially expressed genes for RNA-seq data

Background For RNA-seq data, the aggregated counts of the short reads from the same gene is used to approximate the gene expression level. The count data can be modelled as samples from Poisson distributions with possible different parameters. To detect differentially expressed genes under two situations, statistical methods for detecting the difference of two Poisson means are...

Gene selection and classification for cancer microarray data based on machine learning and similarity measures

Background Microarray data have a high dimension of variables and a small sample size. In microarray data analyses, two important issues are how to choose genes, which provide reliable and good prediction for disease status, and how to determine the final gene set that is best for classification. Associations among genetic markers mean one can exploit information redundancy to...

Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data

Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task of analyzing microarray data for the purpose of, e.g., predicting gene-disease association, feature selection is very important because it provides a way to handle the high...

Preliminary results of FeO mapping using Imaging Interferometer data from Chang’E-1

Information about the variability, and spatial distribution of iron abundance is important to understand lunar geological history and for future resource utilization. In this paper we present a preliminary model to produce an iron abundance map using images taken by an Imaging Interferometer on board the satellite Chang’E-1. Compared with the Clementine UVVIS images, the images...

Preliminary results of TiO2 mapping using Imaging Interferometer data from Chang’E-1

The distribution of titanium abundance on the lunar surface is important knowledge for lunar geologic studies and future resource utilization. In this paper, we develop a preliminary model based on “ground truths” from Apollo and Luna sample-return sites to produce a titanium abundance map from Chang’E-1 Imaging Interferometer (IIM) images. The derived TiO2 abundances are...

Prevalence of Atopic Dermatitis in Chinese Children aged 1–7 ys

ScholarSearch for Chunping Shen in:Nature Research journals • PubMed • Google ScholarSearch for Jianhong Li in:Nature Research journals • PubMed • Google ScholarSearch for Jianzhong Liu in:Nature Research

A Study of the Relationship between Cornea Permeability and Eye Irritation Using Membrane-Interaction QSAR Analysis

A methodology termed membrane-interaction QSAR (MI-QSAR) analysis has been used to develop QSAR models to predict drug permeability coefficients across cornea and its component layers (epithelium, stroma, and endothelium). From a training set of 25 structurally diverse drugs, significant QSAR models are constructed and compared for the permeability of the cornea, epithelium, and...

Categorical QSAR Models for Skin Sensitization based upon Local Lymph Node Assay Classification Measures Part 2: 4D-Fingerprint Three-State and Two-2-State Logistic Regression Models

Three and four state categorical quantitative structure–activity relationship (QSAR) models for skin sensitization have been constructed using data from the murine Local Lymph Node Assay studies. These are the same data we previously used to build two-state (sensitizer, nonsensitizer) QSAR models (Li et al., 2007, Chem. Res. Toxicol. 20, 114–128). 4D-fingerprint descriptors...

Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium

Background It was previously shown that K+ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane. Receptor activation by uracil nucleotides (P2Y2, P2Y4 or P2Y6) leads to a decrease in the electrogenic K+ secretion. The present study was conducted to determine the subtype of the functional...

Smoking among Shanghai medical students and the need for comprehensive intervention strategies

By cluster sampling, 1392 medical students of Shanghai Medical University were investigated with regard to smoking status and their knowledge and attitudes towards smoking and anti-smoking campaigns. The results showed that the smoking rate of medical students was 12.07%–21.42%for male students and 1.81% for female students. Both daily and occasional smoking rate increased as the...

The Identification of Lymphocyte-Like Cells and Lymphoid-Related Genes in Amphioxus Indicates the Twilight for the Emergency of Adaptive Immune System

To seek evidence of a primitive adaptive immune system (AIS) before vertebrate, we examined whether lymphocytes or lymphocyte-like cells and the related molecules participating in the lymphocyte function existed in amphioxus. Anatomical analysis by electron microscopy revealed the presence of lymphocyte-like cells in gills, and these cells underwent morphological changes in...