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Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

Irisin, a recently identified myokine that is released from skeletal muscle following exercise, regulates body weight and influences various metabolic diseases such as obesity and diabetes. In this study, human recombinant nonglycosylated P-irisin (expressed in Escherichia coli prokaryote cell system) or glycosylated E-irisin (expressed in Pichia pastoris eukaryote cell system...

Distinct Changes of BTLA and HVEM Expressions in Circulating CD4

. Selvan Copyright © 2018 Jiayu Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any ... authors declare that they have no competing interests. Authors’ Contributions Jiayu Liu and Jiaqian Li contributed equally to this work. Acknowledgments This study was supported by the Pearl River S&T Nova

Active Tube-Shaped Actuator with Embedded Square Rod-Shaped Ionic Polymer-Metal Composites for Robotic-Assisted Manipulation

This paper reports a new technique involving the design, fabrication, and characterization of an ionic polymer-metal composite- (IPMC-) embedded active tube, which can achieve multidegree-of-freedom (MODF) bending motions desirable in many applications, such as a manipulator and an active catheter. However, traditional strip-type IPMC actuators are limited in only being able to...

Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy

Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy Haitao Pan,1,2 Jiayu Liu,1,2 Wentong Deng,1,2 Jieyu Xing,1,2 Qing Li,1,2 Zhong Wang1,2 1School of

Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells

: Yumei Li, Changhua Zhou, Jing Li, Jiayu Liu, Limin Lin, Li Li. Formal analysis: Yumei Li. Funding acquisition: Zhong Wang. Investigation: Yumei Li, Qing Li, Zhong Wang. Methodology: Yumei Li, Changhua ... Zhou, Jing Li, Jiayu Liu, Limin Lin, Li Li, Donglin Cao, Zhong Wang. Project administration: Qing Li, Zhong Wang. Resources: Changhua Zhou, Jing Li, Jiayu Liu, Limin Lin, Li Li, Donglin Cao, Qing Li