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Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

notes These authors contributed equally: Jie Song, Jing Li, Fangji Yang AffiliationsDepartment of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaJie Song ... Haematology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, ChinaDongjun Lin AuthorsSearch for Jie Song in:Nature Research journals • PubMed • Google Scholar Search for Jing Li in:Nature

Influence of Flexible Foundation on Isolator Wave Effects

This article deals with the interaction between wave effects in mounts and resonances of foundations inflexible vibration isolation systems. A new model is proposed that is represented as a rigid mass supported by two linear unidirectional isolators on a flexible foundation beam, whose closed-form solutions for transmissibility and response ratio are then obtained, with which the...

LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation

Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, relapse and metastasis. The homeobox (HOX) transcription factors play critical roles in many physiological and pathological processes, while, their roles in liver TICs and...

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

BackgroundPersons who develop multiple sclerosis (MS) at a young age may bear a higher genetic risk load than persons who develop MS later in life; however, the contribution of familial influence to the risk of MS, in relation to onset age, has not been established.ObjectiveTo investigate the familial risk of MS at two extremes of the spectrum of MS onset age: early onset (first...

Gastric Parietal Cell and Intestinal Goblet Cell Secretion: a Novel Cell-Mediated In Vivo Metal Nanoparticle Metabolic Pathway Enhanced with Diarrhea Via Chinese Herbs

Up to date, the way in which metal nanoparticles are cleared in vivo has yet to be elucidated well. Herein, we report a novel intestinal goblet cell-mediated in vivo clearance pathway to remove metal nanoparticles. Typical metal nanoparticles such as triangular silver nanoplates, magnetic nanoparticles, gold nanorods, and gold nanoclusters were selected as representative examples...

Influence of Flexible Foundation on Isolator Wave Effects

This article deals with the interaction between wave effects in mounts and resonances of foundations inflexible vibration isolation systems. A new model is proposed that is represented as a rigid mass supported by two linear unidirectional isolators on a flexible foundation beam, whose closed-form solutions for transmissibility and response ratio are then obtained, with which the...

Effectiveness of lomustine and bevacizumab in progressive glioblastoma: a meta-analysis

Effectiveness of lomustine and bevacizumab in progressive glioblastoma: a meta-analysis Jie Song,1 Yue-Qin Xue,2 Ming-Ming Zhao,3 Peng Xu1 1Department of Neurosurgery, Linyi Central Hospital, Linyi

Phylogeny and taxonomy of Laetiporus (Basidiomycota, Polyporales) with descriptions of two new species from western China

Laetiporus is a cosmopolitan genus of brown rot fungi. In this study, L. medogensis and L. xinjiangensis are described as new species from western China, based on morphological and molecular evidence. L. medogensis has only been found on gymnosperms so far and is distinguished by pinkish-buff to clay-buff pileal surface and buff-yellow pore surface, azonate to faintly zonate...

Simultaneous Dual-Color Fluorescence Microscope: A Characterization Study

Background: High spatial resolution and geometric accuracy is crucial for chromosomal analysis of clinical cytogenetic applications. High resolution and rapid simultaneous acquisition of multiple fluorescent wavelengths can be achieved by utilizing concurrent imaging with multiple detectors. However, such class of microscopic systems functions differently from traditional...

Genetic and chemical differentiation characterizes top-geoherb and non-top-geoherb areas in the TCM herb rhubarb

Hou Xiaojie Sun Kai Fan Min Huang Yun Zhou Jie Song OPEN Medicinal herbs of high quality and with significant clinical effects have been designated as topgeoherbs in traditional Chinese medicine (TCM

Estimation of a Permeability Field within the Two-Phase Porous Media Flow Using Nonlinear Multigrid Method

Qinhuangdao, Qinhuangdao 066000, China 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130000, China Correspondence should be addressed to Jie Song; moc.361 ... @eknahcuf_gnijnehc Received 29 October 2016; Revised 30 January 2017; Accepted 7 February 2017; Published 23 February 2017 Academic Editor: Yann Favennec Copyright © 2017 Tao Liu and Jie Song. This is an open

Estimation of a Permeability Field within the Two-Phase Porous Media Flow Using Nonlinear Multigrid Method

Qinhuangdao, Qinhuangdao 066000, China 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130000, China Correspondence should be addressed to Jie Song; moc.361 ... @eknahcuf_gnijnehc Received 29 October 2016; Revised 30 January 2017; Accepted 7 February 2017; Published 23 February 2017 Academic Editor: Yann Favennec Copyright © 2017 Tao Liu and Jie Song. This is an open

Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication

increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway. - Jie Song and Yajie

Low Habitual Dietary Calcium and Linear Growth from Adolescence to Young Adulthood: results from the China Health and Nutrition Survey

FangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100191, ChinaAiping Fang, Keji Li, He Li, Meihan Guo, Jingjing He, Xin Shen & Jie Song AuthorsSearch for Aiping ... journals • PubMed • Google Scholar Search for Jie Song in:Nature Research journals • PubMed • Google Scholar Contributions A.P.F. analyzed the data and wrote the paper; A.P.F. and K.J.L. designed and

The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway

-bin Gao,3 Chun-wei Xu,4 Chang-qian Zeng,1 Jie Song,1 Yu Xu,1 Wen-cai Weng,2 and Wen-bo Liang1 1Medical College of Dalian University, Dalian 116622, China 2Xin Hua Affiliated Hospital of Dalian ... ’ Contributions Wen-bo Liang provided the programs and ideas of experiment. Liang Su, Yi-ming Jiang, Wen-bin Gao, Chun-wei Xu, Yu Xu, and Wen-cai Weng contributed to the completion of the experiment. Jie Song and

The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway

-bin Gao,3 Chun-wei Xu,4 Chang-qian Zeng,1 Jie Song,1 Yu Xu,1 Wen-cai Weng,2 and Wen-bo Liang1 1Medical College of Dalian University, Dalian 116622, China 2Xin Hua Affiliated Hospital of Dalian ... ’ Contributions Wen-bo Liang provided the programs and ideas of experiment. Liang Su, Yi-ming Jiang, Wen-bin Gao, Chun-wei Xu, Yu Xu, and Wen-cai Weng contributed to the completion of the experiment. Jie Song and

Molecular cytogenetic identification of a novel wheat-Agropyron elongatum chromosome translocation line with powdery mildew resistance

Li, Zhengang Ru. Writing ± original draft: Xiaojun Li. Writing ± review & editing: Xiaojun Li, Zhengang Ru. Investigation: Xiaojun Li, Xiaoling Jiang, Xiangdong Chen, Jie Song, Cuicui Ren, Yajuan 12

The effect of bovine BST2A1 on the release and cell-to-cell transmission of retroviruses

Human BST2 (hBST2, also called Tetherin) is a host restriction factor that blocks the release of various enveloped viruses. BST2s from different mammals also possess antiviral activity. Bovine BST2s (bBST2s), bBST2A1 and bBST2A2, reduce production of cell-free bovine leukemia virus (BLV) and vesicular stomatitis virus (VSV). However, the effect of bBST2 on other retroviruses...

Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus

Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice only. This study investigates how age affects cartilage and subchondral bone changes in mouse joints following DMM. DMM was performed on male C57BL/6...

The Electrical Resistivity and Acoustic Emission Response Law and Damage Evolution of Limestone in Brazilian Split Test

The Brazilian split test was performed on two groups of limestone samples with loading directions vertical and parallel to the bedding plane, and the response laws of the electrical resistivity and acoustic emission (AE) in the two loading modes were obtained. The test results showed that the Brazilian split test with loading directions vertical and parallel to the bedding showed...