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Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells

Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells Jie Wang,1,2 Miao Li,2 Xiaolin Cui,1 Dongyue Lv,1 Lingling Jin,1 Muhammad Khan,3 Tonghui Ma1 ... project. Jie Wang, Miao Li, Xiaolin Cui, Dongyue Lv, and Lingling Jin conducted the experiments. Data were analyzed by Muhammad Khan and Tonghui Ma. The manuscript was written by Jie Wang and approved by

Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo

Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo Jie Wang,1 Huaxin Liang,2 Meiyan Sun,3 Lei Zhang,3 Huijing Xu,3 Wei Liu,3 Yan Li,3 Yue Zhou,4 Yingya Li,5

Ectomycorrhizal fungi reduce the light compensation point and promote carbon fixation of Pinus thunbergii seedlings to adapt to shade environments

We examined the effects of three ectomycorrhizal (ECM) symbionts on the growth and photosynthesis capacity of Japanese black pine (Pinus thunbergii) seedlings and estimated physiological and photosynthetic parameters such as the light compensation point (LCP), biomass, and phosphorus (Pi) concentration of P. thunbergii seedlings. Through this investigation, we documented a new...

Multiferroic Phases and Transitions in Ferroelectric Lead Titanate Nanodots

Discovery of novel phases and their associated transitions in low-dimensional nanoscale systems is of central interest as the origin of emergent phenomena and new device paradigms. Although typical ferroelectrics such as PbTiO3 exhibit diverse phase transition sequences, the conventional incompatible mechanisms of ferroelectricity and magnetism keep them as simply nonmagnetic...

Computer-Based Cognitive Programs for Improvement of Memory, Processing Speed and Executive Function during Age-Related Cognitive Decline: A Meta-Analysis

Background Several studies have assessed the effects of computer-based cognitive programs (CCP) in the management of age-related cognitive decline, but the role of CCP remains controversial. Therefore, this systematic review evaluated the evidence on the efficacy of CCP for age-related cognitive decline in healthy older adults. Methods Six electronic databases (through October...

Differential radio map-based robust indoor localization

While wireless local area network-based indoor localization is attractive, the problems concerning how to capture the signal-propagating character in the complex dynamic environment and how to accommodate the receiver gain difference of different mobile devices are challenging. In this article, we solve these problems by modeling them as common mode noise and develop a...

The response and recovery of the Arabidopsis thaliana transcriptome to phosphate starvation

Background Over application of phosphate fertilizers in modern agriculture contaminates waterways and disrupts natural ecosystems. Nevertheless, this is a common practice among farmers, especially in developing countries as abundant fertilizers are believed to boost crop yields. The study of plant phosphate metabolism and its underlying genetic pathways is key to discovering...

Rapid Urban Malaria Appraisal (RUMA) IV: Epidemiology of urban malaria in Cotonou (Benin)

Background An estimated 40 % of the population in Benin lives in urban areas. The purpose of the study was to estimate malaria endemicity and the fraction of malaria-attributable fevers in health facilities in Cotonou. Methods A health care system evaluation and a series of school parasitaemia surveys and health facility-based surveys were carried out during the dry season in of...

Rapid Urban Malaria Appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan)

Background Currently, there is a significant lack of knowledge concerning urban malaria patterns in general and in Abidjan in particular. The prevalence of malaria, its distribution in the city and the fractions of fevers attributable to malaria in the health facilities have not been previously investigated. Methods A health facility-based survey and health care system evaluation...

Rapid Urban Malaria Appraisal (RUMA) II: Epidemiology of urban malaria in Dar es Salaam (Tanzania)

Background The thinking behind malaria research and control strategies stems largely from experience gained in rural areas and needs to be adapted to the urban environment. Methods A rapid assessment of urban malaria was conducted in Dar es Salaam in June-August, 2003 using a standard Rapid Urban Malaria Appraisal (RUMA) methodology. This study was part of a multi-site study in...

Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse

Tetsuro Izumi Hiromi Yokota-Hashimoto Shengli Zhao Jie Wang Philippe A. Halban Toshiyuki Takeuchi - sis in response to ER stress (10,11). Thus these findings indicate that the CHOP-dependent cell

Rapid urban malaria appraisal (RUMA) I: Epidemiology of urban malaria in Ouagadougou

Background Rapid urbanization in sub-Saharan Africa has a major impact on malaria epidemiology. While much is known about malaria in rural areas in Burkina Faso, the urban situation is less well understood. Methods An assessment of urban malaria was carried out in Ouagadougou in November -December, 2002 during which a rapid urban malaria appraisal (RUMA) was applied. Results The...

Rapid urban malaria appraisal (RUMA) in sub-Saharan Africa

Background The rapid urban malaria appraisal (RUMA) methodology aims to provide a cost-effective tool to conduct rapid assessments of the malaria situation in urban sub-Saharan Africa and to improve the understanding of urban malaria epidemiology. Methods This work was done in Yopougon municipality (Abidjan), Cotonou, Dar es Salaam and Ouagadougou. The study design consists of...

Genome-wide association study identifies three novel loci for type 2 diabetes

Chen Peng Cheng Hu Ronald C. W. Ma Minako Imamura Minoru Iwata Tatsuhiko Tsunoda Takashi Morizono Nobuhiro Shojima Wing Yee So Ting Fan Leung Patrick Kwan Rong Zhang Jie Wang Weihui Yu Hiroshi Maegawa