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Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes

Assessing the phenotypic diversity underlying tumour progression requires the identification of variations in the respective molecular interaction networks. Here we report proof-of-concept for a platform called poly-ligand profiling (PLP) that surveys these system states and distinguishes breast cancer patients who did or did not derive benefit from trastuzumab. We perform tissue...

Are mergers responsible for universal halo properties?

N-body simulations of cold dark matter (CDM) have shown that, in this hierarchical structure formation model, dark matter halo properties, such as the density profile, the phase-space density profile, the distribution of axial ratio, the distribution of spin parameter and the distribution of internal specific angular momentum, follow ‘universal’ laws or distributions. Here, we...

Discreteness effects in simulations of hot/warm dark matter

In hot/warm dark matter (HDM/WDM) universes the density fluctuations at early times contain very little power below a characteristic wavelength related inversely to the particle mass. We study how discreteness noise influences the growth of non-linear structures smaller than this coherence scale in N-body simulations of cosmic structure formation. It has been known for 20 yr that...

The dependence of galaxy formation on cosmological parameters: can we distinguish between the WMAP1 and WMAP3 parameter sets?

Jie Wang Gabriella De Lucia Manfred G. Kitzbichler Simon D. M. White Max-Planck-Institut fur Astrophysik Karl-Schwarzschild-Str. D- Garching Germany A B S T R A C T We combine N-body simulations of

Secondary infall and the pseudo-phase-space density profiles of cold dark matter haloes

We use N-body simulations to investigate the radial dependence of the density, ρ, and velocity dispersion, σ, in cold dark matter (CDM) haloes. In particular, we explore how closely Q≡ρ/σ3, a surrogate measure of the phase-space density, follows a power law in radius. Our study extends earlier work by considering, in addition to spherically averaged profiles, local Q estimates...

Phase-space structure in the local dark matter distribution and its signature in direct detection experiments

We study predictions for dark matter (DM) phase-space structure near the Sun based on high-resolution simulations of six galaxy haloes taken from the Aquarius project. The local DM density distribution is predicted to be remarkably smooth; the density at the Sun differs from the mean over a best-fitting ellipsoidal equidensity contour by less than 15 per cent at the 99.9 per cent...