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11 papers found.
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A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD

Jie Wang-Jairaj,3 Dawn A Midwinter,3 David B Rubin,4 Catherine A Scott-Wilson,4 Courtney Crim4 1Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of

The spatial distribution of galactic satellites in the Λ cold dark matter cosmology

We investigate the spatial distribution of galactic satellites in high-resolution simulations of structure formation in the Λ cold dark matter (ΛCDM) model: the Aquarius dark matter simulations of individual haloes and the Millennium-II simulation of a large cosmological volume. To relate the simulations to observations of the Milky Way we use two alternative models to populate...

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

Background Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain. Methods Individual patient data were collected from six studies (32,057 participants); including one population-based cohort and five randomized controlled trials. Participants were grouped into one of five CKD...

Language barrier and its relationship to diabetes and diabetic retinopathy

Background Language barrier is an important determinant of health care access and health. We examined the associations of English proficiency with type-2 diabetes (T2DM) and diabetic retinopathy (DR) in Asian Indians living in Singapore, an urban city where English is the predominant language of communication. Methods This was a population-based, cross-sectional study. T2DM was...

Substructure lensing: effects of galaxies, globular clusters and satellite streams

Lensing flux-ratio anomalies have been frequently observed and taken as evidence for the presence of abundant dark matter substructures in lensing galaxies, as predicted by the cold dark matter (CDM) model of cosmogony. In previous work, we examined the cusp–caustic relations of the multiple images of background quasars lensed by galaxy-scale dark matter haloes, using a suite of...

The haloes of bright satellite galaxies in a warm dark matter universe

High-resolution N-body simulations of galactic cold dark matter haloes indicate that we should expect to find a few satellite galaxies around the Milky Way whose haloes have a maximum circular velocity in excess of 40 km s−1. Yet, with the exception of the Magellanic Clouds and the Sagittarius dwarf, which likely reside in subhaloes with significantly larger velocities than this...

Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium

The Encyclopedia of DNA Elements (ENCODE) consortium aims to identify all functional elements in the human genome including transcripts, transcriptional regulatory regions, along with their chromatin states and DNA methylation patterns. The ENCODE project generates data utilizing a variety of techniques that can enrich for regulatory regions, such as chromatin immunoprecipitation...

An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: Analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome 1q21-q25

Background The HapMap project aimed to catalog millions of common single nucleotide polymorphisms (SNPs) in the human genome in four major populations, in order to facilitate association studies of complex diseases. To examine the transferability of Han Chinese in Beijing HapMap data to the Southern Han Chinese in Shanghai, we performed comparative analyses between genotypes from...

Effects of dark matter substructures on gravitational lensing: results from the Aquarius simulations

We use the high-resolution Aquarius simulations of the formation of Milky Way-sized haloes in the Λ cold dark matter cosmology to study the effects of dark matter substructures on gravitational lensing. Each halo is resolved with ∼108 particles (at a mass resolution mp∼ 103 to 104 h−1 M⊙) within its virial radius. Subhaloes with masses msub≳ 105 h−1 M⊙ are well resolved, an...

Rapid Urban Malaria Appraisal (RUMA) II: Epidemiology of urban malaria in Dar es Salaam (Tanzania)

Background The thinking behind malaria research and control strategies stems largely from experience gained in rural areas and needs to be adapted to the urban environment. Methods A rapid assessment of urban malaria was conducted in Dar es Salaam in June-August, 2003 using a standard Rapid Urban Malaria Appraisal (RUMA) methodology. This study was part of a multi-site study in...

Rapid urban malaria appraisal (RUMA) I: Epidemiology of urban malaria in Ouagadougou

Background Rapid urbanization in sub-Saharan Africa has a major impact on malaria epidemiology. While much is known about malaria in rural areas in Burkina Faso, the urban situation is less well understood. Methods An assessment of urban malaria was carried out in Ouagadougou in November -December, 2002 during which a rapid urban malaria appraisal (RUMA) was applied. Results The...