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Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo

Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo Jie Wang,1 Huaxin Liang,2 Meiyan Sun,3 Lei Zhang,3 Huijing Xu,3 Wei Liu,3 Yan Li,3 Yue Zhou,4 Yingya Li,5

Methodological comparison of alpine meadow evapotranspiration on the Tibetan Plateau, China

. Methodology: Yaping Chang, Jie Wang, Yongjian Ding, Fengjing Liu, Shiqiang Zhang. Project administration: Dahe Qin, Shiqiang Zhang. Resources: Dahe Qin. Supervision: Shiqiang Zhang. Validation: Yaping Chang ... , Jie Wang. Liu, Shiqiang Zhang. Writing ± original draft: Yaping Chang, Yongjian Ding, Shiqiang Zhang. Writing ± review & editing: Jie Wang, Dahe Qin, Yongjian Ding, Qiudong Zhao, Fengjing 17 / 20 18

Distributed energy management for interconnected operation of combined heat and power-based microgrids with demand response

license, and indicate if changes were made. Jie WANG is pursuing the M.S. degree in the School of Electrical and Electronic Engineering of North China Electric Power University. Her research interest is

CTCF-Mediated and Pax6-Associated Gene Expression in Corneal Epithelial Cell-Specific Differentiation

Background The purpose of the study is to elicit the epigenetic mechanism involving CCCTC binding factor (CTCF)-mediated chromatin remodeling that regulates PAX6 gene interaction with differentiation-associated genes to control corneal epithelial differentiation. Methods Cell cycle progression and specific keratin expressions were measured to monitor changes of differentiation...

Integrated omics dissection of proteome dynamics during cardiac remodeling

Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics experiments is rarely explored. Here we report an integrated omics approach, incorporating measurements of transcript abundance, protein abundance, and protein turnover to map the landscape of proteome remodeling in a mouse model...

Temporal consistency between gross primary production and solar-induced chlorophyll fluorescence in the ten most populous megacity areas over years

The gross primary production (GPP) of vegetation in urban areas plays an important role in the study of urban ecology. It is difficult however, to accurately estimate GPP in urban areas, mostly due to the complexity of impervious land surfaces, buildings, vegetation, and management. Recently, we used the Vegetation Photosynthesis Model (VPM), climate data, and satellite images to...

Hybrid weakness in a rice interspecific hybrid is nitrogen-dependent, and accompanied by changes in gene expression at both total transcript level and parental allele partitioning

Background Hybrid weakness, a phenomenon opposite to heterosis, refers to inferior growth and development in a hybrid relative to its pure-line parents. Little attention has been paid to the phenomenological or mechanistic aspect of hybrid weakness, probably due to its rare occurrence. Methodology/Principal findings Here, using a set of interspecific triploid F1 hybrids between...

A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD

Jie Wang-Jairaj,3 Dawn A Midwinter,3 David B Rubin,4 Catherine A Scott-Wilson,4 Courtney Crim4 1Division of Pulmonary, Allergy and Critical Care Medicine and UAB Lung Health Center, University of

Evaluating and Reporting the Immunogenicity Impacts for Biological Products—a Clinical Pharmacology Perspective

Immunogenicity assessment is important for biological products due to potential impacts of immunogenicity on safety and efficacy. We reviewed the prescribing information and the FDA’s clinical pharmacology review of 121 approved biological products for evaluating and reporting of immunogenicity data. Of the 121 products, 89% (n = 108) reported the incidence of immunogenicity and...

TEMP: a computational method for analyzing transposable element polymorphism in populations

Insertions and excisions of transposable elements (TEs) affect both the stability and variability of the genome. Studying the dynamics of transposition at the population level can provide crucial insights into the processes and mechanisms of genome evolution. Pooling genomic materials from multiple individuals followed by high-throughput sequencing is an efficient way of...

A retrospective study of californium-252 neutron brachytherapy combined with EBRT versus 3D-CRT in the treatment of esophageal squamous cell cancer

Li, Jinyi Lang, Jie Wang, Jian Wang, Huiming Liu, Xitang Jia, Bo Liu, and C-K Chris Wang declare that they have no competing financial interests. Authors’ contributions QW and TL conceived of the

Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

Oxidative protein folding in the endoplasmic reticulum (ER) has emerged as a potentially significant source of cellular reactive oxygen species (ROS). Recent studies suggest that levels of ROS generated as a byproduct of oxidative folding rival those produced by mitochondrial respiration. Mechanisms that protect cells against oxidant accumulation within the ER have begun to be...

Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome

Arginine methylation is a posttranslational modification that impacts wide-ranging cellular functions, including transcription, mRNA splicing and translation. RNA binding proteins (RBPs) represent one of the largest classes of arginine methylated proteins in both mammals and the early diverging parasitic protozoan, Trypanosoma brucei. Here, we report the effects of arginine...

Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

Jie Wang 0 David A. Richards () 0 0 Department of Anesthesia, Cincinnati Children's Hospital Medical Center , MLC2001, 3333 Burnet Avenue, Cincinnati, OH 45229, USA - Summary PIP2 and PIP3 are

Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes

M5S 3B2 1 Department of Molecular Genetics, University of Toronto , Toronto, ON , Canada M5S 1A8 2 Present address: Jie Wang, Department of Biochemistry, University at Buffalo, and NY State Center of

Basic Fibroblast Growth Factor Stimulates the Proliferation of Bone Marrow Mesenchymal Stem Cells in Giant Panda (Ailuropoda melanoleuca)

It has been widely known that the giant panda (Ailuropoda melanoleuca) is one of the most endangered species in the world. An optimized platform for maintaining the proliferation of giant panda mesenchymal stem cells (MSCs) is very necessary for current giant panda protection strategies. Basic fibroblast growth factor (bFGF), a member of the FGF family, is widely considered as a...

Spatial Regulation of Exocytic Site and Vesicle Mobilization by the Actin Cytoskeleton

Numerous studies indicate a role for the actin cytoskeleton in secretion. Here, we have used evanescent wave and widefield fluorescence microscopy to study the involvement of the actin cytoskeleton in secretion from PC12 cells. Secretion was assayed as loss of ANF-EmGFP in widefield mode. Under control conditions, depolarization induced secretion showed two phases: an initial...

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

Background Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain. Methods Individual patient data were collected from six studies (32,057 participants); including one population-based cohort and five randomized controlled trials. Participants were grouped into one of five CKD...

Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

Transcriptional gene silencing (TGS) can serve as an innate immunity against invading DNA viruses throughout Eukaryotes. Geminivirus code for TrAP protein to suppress the TGS pathway. Here we identified an Arabidopsis H3K9me2 histone methyltransferase, Su(var)3-9 homolog 4 (SUVH4/KYP), as a bona fide cellular target of TrAP. TrAP interacts with the catalytic domain of KYP and...

Compact Visibility Representation of Plane Graphs

The visibility representation (VR for short) is a classical representation of plane graphs. It has various applications and has been extensively studied. A main focus of the study is to minimize the size of the VR. It is known that there exists a plane graph $G$ with $n$ vertices where any VR of $G$ requires a grid of size at least (2/3)n x((4/3)n-3) (width x height). For upper...