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8 papers found.
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Induction Chemotherapy Followed by Radiotherapy versus Concurrent Chemoradiotherapy in elderly patients with nasopharyngeal carcinoma: finding from a propensity-matched analysis

Background To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients received either induction chemotherapy followed by radiotherapy(IC + RT) or concurrent chemoradiotherapy (CCRT) was therefore undertaken to provide a more accurate basis...

Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies

Background Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain. Methods Individual patient data were collected from six studies (32,057 participants); including one population-based cohort and five randomized controlled trials. Participants were grouped into one of five CKD...

Randomized phase III trial of amrubicin/cisplatin versus etoposide/cisplatin as first-line treatment for extensive small-cell lung cancer

Hao 1 Jie Wang 10 Chengping Hu 16 Baohui Han 15 Xiaoqing Liu 14 Li Zhang 13 Huiping Wan 18 Zhongjun Xia 17 Yunpeng Liu 12 Wei Li 8 Mei Hou 9 Helong Zhang 6 Qingyu Xiu 7 Yunzhong Zhu 4 Jifeng Feng 5

Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

Background MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31) is obviously up-regulated in colorectal cancer (CRC), there is no study on the functional roles of miR-31 in CRC. Methods Anti-miR™ miRNA 31 inhibitor (anti-miR-31) is a sequence-specific and...

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

Background Drug resistance is a major challenge in cancer therapeutics. Abundant evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic treatments, rendering cancers cells drug-resistant. Flap endonuclease 1 (FEN1) plays critical roles in DNA replication and repair and in counteracting replication stress, which is a key mechanism for many...

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

Johannes Stratmann 0 Chao-Jie Wang Sebastian Gnosa sa Wallin David Hinselwood Xiao-Feng Sun Hong Zhang 0 0 Division of Biomedicine, Systems Biology Research Centre, School of Life Sciences, Skovde

MiR-181b sensitizes glioma cells to teniposide by targeting MDM2

Wang 0 Tony Shing-shun To Zong-ping Zhang Yong-gao Mu 0 Zhong-ping Chen 0 0 Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South

The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma

Background Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix...