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Genome-wide identification of the fatty acid desaturases gene family in four Aspergillus species and their expression profile in Aspergillus oryzae

Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae, Aspergillus flavus, Aspergillus fumigatus and Aspergillus nidulans genomes through database searches, which were classified...

Production of bioactive liver-targeting interferon Mu-IFN-CSP by soluble prokaryotic expression

A novel liver-targeting interferon (IFN-CSP) was successfully over-expressed in our previous work. The in vitro and in vivo investigation revealed that IFN-CSP has significant anti-hepatitis B virus (HBV) effect and liver-targeting capacity. However, due to the IFN-CSP tends to form inclusion bodies in recombinant Escherichia coli (E. coli), efficient production of the soluble...

Experimental Study on Velocity Profiles with Different Roughness Elements in a Flume

The classical log law for velocity profile is applied to engineering practice. Field observations indicate that the composition of the bed materials obviously influences the shape of vertical velocity distribution. To clearly understand the roughness effect, six types of materials were laid separately at various depths for the investigation of the effects of roughness elements on...

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

PANG, Hong LIAO, Lu-yong ZHANG, Jian-rong GAO, Qing YE, and Jia LI designed the research; Tao PANG, Yun-jie WANG, Yuan-xue GAO, Yuan XU, Yu-bo ZHOU, and Lei XU performed the research; Qiu LI and Qing

Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice

, and Shu-pei ZHOU performed the research; Jing-yun npg LI, Tian-yan ZHOU, Li-jie WANG, and Wei LU analyzed the data; Jing-yun LI and Tian-yan ZHOU wrote the manuscript. Abbreviations ER, erlotinib; SU

Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208

development of estrogenthe research; Xi- wei JI , Ming HUA , Li-jie WANG , Si-yuan dependent cancers . Cancer Sci 2012 ; 103 : 1000 - 9 . WANG , Liang LI , Yan SONG , and Yin YUAN performed the 19 Pasqualini JR

Effects and mechanism of aromatic aminoketone SY0916 on osteoclastic bone destruction

National Natural Science Foundation of China (No 30472033). Author contribution Wen-jie WANG and Lin WANG designed the research; Lin WANG, Shan-ying PENG, Ping LI, and Yang LIU performed the research; Lin ... WANG, Shan-ying PENG, and Ping LI analyzed the data; Lin WANG and Wen-jie WANG wrote the paper. Abbreviations RA, rheumatoid arthritis; CIA, collagen-induced arthritis; PAF, platelet-activating factor

Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population

, Denmark, for providing the free monoclonal antibodies, including OXI-005, HUI-018, PEP001, and HUI-001. Author contribution En-zhi JIA designed research; Jie WANG, Yun ZHANG, Zhi-jian YANG, Tie-bing ZHU ... , Lian-sehng WANG, Bo CHEN, Ke-jiang CAO, Jun HUANG, Wen-zhu MA, En-zhi JIA performed research; Jie WANG, En-zhi JIA analyzed data; Jie WANG wrote the paper. 1 2 3 4 5 6 7 8 9 Utsunomiya N , Ohagi S

Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis

Aim:To investigate the effects of tanshinone IIA (Tan IIA) on the regulation of the production of endothelin (ET)-1 (including large ET-1), mRNA levels of ET-1, endothelin-converting enzyme-1 (ECE-1), endothelin-A receptor (ETA) and endothelin-B receptor (ETB) induced by TNF-α in rat brain microvascular endothelial cells (BMVEC).Methods:The ET-1 release (including large ET-1...

Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients

Aim:To investigate the possible association of the CYP2D6 gene C100T polymorphism and the CYP1A2 gene C163A polymorphism with tardive dyskinesia (TD) in Chinese patients with schizophrenia.Methods:The recruited schizophrenic patients were assessed with the Abnormal Involuntary Movement Scale (AIMS), and divided into groups with TD (n=91) and without TD (n=91) according to the...

Power Device Thermal Fault Tolerant Control of High-Power Three-Level Explosion-Proof Inverter Based on Holographic Equivalent Dual-Mode Modulation

It is necessary for three-level explosion-proof inverters to have high thermal stability and good output characteristics avoiding problems caused by power devices, such as IGBT, so it becomes a hot and difficult research point using only one control algorithm to guarantee both output characteristics and high thermal stability. Firstly, the simplified SVPWM (Space Vector Pulse...

Power Device Thermal Fault Tolerant Control of High-Power Three-Level Explosion-Proof Inverter Based on Holographic Equivalent Dual-Mode Modulation

It is necessary for three-level explosion-proof inverters to have high thermal stability and good output characteristics avoiding problems caused by power devices, such as IGBT, so it becomes a hot and difficult research point using only one control algorithm to guarantee both output characteristics and high thermal stability. Firstly, the simplified SVPWM (Space Vector Pulse...

C1 regularity of the stable subspaces with a general nonuniform dichotomy

For nonautonomous linear difference equations, we establish C1 regularity of the stable subspaces under sufficiently C1-parameterized perturbations. We consider the general case of nonuniform dichotomies, which corresponds to the existence of what we call nonuniform (μ, ν)-dichotomies. Mathematics Subject Classification 2000: Primary 34D09; 34D10; 37D99.

C 1 regularity of the stable subspaces with a general nonuniform dichotomy

For nonautonomous linear difference equations, we establish C 1 regularity of the stable subspaces under sufficiently C 1-parameterized perturbations. We consider the general case of nonuniform dichotomies, which corresponds to the existence of what we call nonuniform (μ, ν)-dichotomies. Mathematics Subject Classification 2000: Primary 34D09; 34D10; 37D99.

Laboratory Evaluation of Aging Behaviour of SBS Modified Asphalt

, Ministry of Transport, Beijing 100088, China Correspondence should be addressed to Jie Wang; nc.hoir@gnaw.j Received 12 April 2017; Revised 8 June 2017; Accepted 21 June 2017; Published 27 August 2017 ... Academic Editor: Hainian Wang Copyright © 2017 Jie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Laboratory Evaluation of Aging Behaviour of SBS Modified Asphalt

, Ministry of Transport, Beijing 100088, China Correspondence should be addressed to Jie Wang; nc.hoir@gnaw.j Received 12 April 2017; Revised 8 June 2017; Accepted 21 June 2017; Published 27 August 2017 ... Academic Editor: Hainian Wang Copyright © 2017 Jie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Laboratory Evaluation of Aging Behaviour of SBS Modified Asphalt

, Ministry of Transport, Beijing 100088, China Correspondence should be addressed to Jie Wang; nc.hoir@gnaw.j Received 12 April 2017; Revised 8 June 2017; Accepted 21 June 2017; Published 27 August 2017 ... Academic Editor: Hainian Wang Copyright © 2017 Jie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Surface Albedo Variation and Its Influencing Factors over Dongkemadi Glacier, Central Tibetan Plateau

Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China Received 6 January 2015; Accepted 16 March 2015 Academic Editor: Sven-Erik Gryning Copyright © 2015 Jie ... Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original

Serum uric acid levels and hyperuricemia in patients with psoriasis: a hospital-based cross-sectional study

cases, Critical review of the manuscript Zhen-Jie Wang 0000-0002-6752-1690 Statistical analysis, Approval of the final version of the manuscript, Design and planning of the study, Collecting